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FSHD myotubes with different phenotypes exhibit distinct proteomes.
Tassin A, Leroy B, Laoudj-Chenivesse D, Wauters A, Vanderplanck C, Le Bihan MC, Coppée F, Wattiez R, Belayew A. Tassin A, et al. Among authors: vanderplanck c. PLoS One. 2012;7(12):e51865. doi: 10.1371/journal.pone.0051865. Epub 2012 Dec 18. PLoS One. 2012. PMID: 23272181 Free PMC article.
The FSHD atrophic myotube phenotype is caused by DUX4 expression.
Vanderplanck C, Ansseau E, Charron S, Stricwant N, Tassin A, Laoudj-Chenivesse D, Wilton SD, Coppée F, Belayew A. Vanderplanck C, et al. PLoS One. 2011;6(10):e26820. doi: 10.1371/journal.pone.0026820. Epub 2011 Oct 28. PLoS One. 2011. PMID: 22053214 Free PMC article.
DUX4 expression in FSHD muscle cells: how could such a rare protein cause a myopathy?
Tassin A, Laoudj-Chenivesse D, Vanderplanck C, Barro M, Charron S, Ansseau E, Chen YW, Mercier J, Coppée F, Belayew A. Tassin A, et al. Among authors: vanderplanck c. J Cell Mol Med. 2013 Jan;17(1):76-89. doi: 10.1111/j.1582-4934.2012.01647.x. Epub 2012 Dec 4. J Cell Mol Med. 2013. PMID: 23206257 Free PMC article.
The Role of D4Z4-Encoded Proteins in the Osteogenic Differentiation of Mesenchymal Stromal Cells Isolated from Bone Marrow.
de la Kethulle de Ryhove L, Ansseau E, Nachtegael C, Pieters K, Vanderplanck C, Geens M, Sermon K, Wilton SD, Coppée F, Lagneaux L, Belayew A. de la Kethulle de Ryhove L, et al. Among authors: vanderplanck c. Stem Cells Dev. 2015 Nov 15;24(22):2674-86. doi: 10.1089/scd.2014.0575. Epub 2015 Aug 26. Stem Cells Dev. 2015. PMID: 26192274
DUX4c is up-regulated in FSHD. It induces the MYF5 protein and human myoblast proliferation.
Ansseau E, Laoudj-Chenivesse D, Marcowycz A, Tassin A, Vanderplanck C, Sauvage S, Barro M, Mahieu I, Leroy A, Leclercq I, Mainfroid V, Figlewicz D, Mouly V, Butler-Browne G, Belayew A, Coppée F. Ansseau E, et al. Among authors: vanderplanck c. PLoS One. 2009 Oct 15;4(10):e7482. doi: 10.1371/journal.pone.0007482. PLoS One. 2009. PMID: 19829708 Free PMC article.