Evolved histone tail regulates 53BP1 recruitment at damaged chromatin.
Kelliher JL, Folkerts ML, Shen KV, Song W, Tengler K, Stiefel CM, Lee SO, Dray E, Zhao W, Koss B, Pannunzio NR, Leung JW.
Kelliher JL, et al.
Nat Commun. 2024 May 31;15(1):4634. doi: 10.1038/s41467-024-49071-w.
Nat Commun. 2024.
PMID: 38821984
Free PMC article.
Interestingly, H2AX recruits 53BP1 independently from the MDC1-RNF8-RNF168 pathway through its evolved C-terminal linker region with S139 phosphorylation. Mechanistically, 53BP1 recruitment to damaged chromatin is mediated by the interaction between the H2AX C-termi …
Interestingly, H2AX recruits 53BP1 independently from the MDC1-RNF8-RNF168 pathway through its evolved C-terminal linker region with …