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24 results
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Targeting the human beta(c) receptor inhibits contact dermatitis in a transgenic mouse model.
Yip KH, McKenzie D, Ramshaw HS, Chao J, McClure BJ, Raquet E, Kraushaar T, Röder J, Maxwell M, Alhamdoosh M, Hammet A, Fong JH, Zeglinski K, Monaghan K, Pant H, Grimbaldeston MA, Vairo G, Wilson NJ, Owczarek CM, Hercus TR, Lopez AF, Tumes DJ. Yip KH, et al. J Invest Dermatol. 2021 Sep 16:S0022-202X(21)02214-4. doi: 10.1016/j.jid.2021.07.183. Online ahead of print. J Invest Dermatol. 2021. PMID: 34537191
However, the species specificity of beta(c) has precluded testing of inhibitors of human beta(c) in mouse models. To overcome this problem, we developed a human beta(c) receptor transgenic (hbeta(c)Tg) mouse strain with hematopoietic cell-specific expr …
However, the species specificity of beta(c) has precluded testing of inhibitors of human beta(c) in mouse models. To overcome …
Catalytic asymmetric benzylic C-H activation by means of carbenoid-induced C-H insertions.
Davies HM, Jin Q, Ren P, Kovalevsky AY. Davies HM, et al. J Org Chem. 2002 Jun 14;67(12):4165-9. doi: 10.1021/jo016351t. J Org Chem. 2002. PMID: 12054951
Tetrakis[N-[4-dodecylphenyl)sulfonyl]-(S)-prolinate]dirhodium [Rh(2)(S-DOSP)(4)]-catalyzed decomposition of methyl aryldiazoacetates in the presence of substituted ethylbenzenes results in benzylic C-H activation by means of a rhodium-carbenoid-induced C-H insertion …
Tetrakis[N-[4-dodecylphenyl)sulfonyl]-(S)-prolinate]dirhodium [Rh(2)(S-DOSP)(4)]-catalyzed decomposition of methyl aryldiazoacetates in the …
Is BRCA2 c.9079 G>A a predisposing variant for early onset breast cancer?
Hammet F, George J, Tesoriero AA, Jenkins MA, Schroen C, Smith L, Grabosch-Meehan A, Dite G, McCredie MR, Giles GG, Tavtigian SV, Hopper JL, Southey MC. Hammet F, et al. Breast Cancer Res Treat. 2008 May;109(1):177-9. doi: 10.1007/s10549-007-9624-6. Epub 2007 Jun 5. Breast Cancer Res Treat. 2008. PMID: 17549625 No abstract available.
Cyclization of interlocked fumaramides into β-lactams: experimental and computational mechanistic assessment of the key intercomponent proton transfer and the stereocontrolling active pocket.
Martinez-Cuezva A, Pastor A, Marin-Luna M, Diaz-Marin C, Bautista D, Alajarin M, Berna J. Martinez-Cuezva A, et al. Chem Sci. 2020 Nov 11;12(2):747-756. doi: 10.1039/d0sc05757f. Chem Sci. 2020. PMID: 34163808 Free PMC article.
The mechanistic analysis comprises the experimental evaluation of the structure-reactivity relationship for a wide range of fumaramides [2]rotaxanes (Hammet-plots), KIE studies with deuterium-labelled interlocked fumaramides and computational analysis of two alternative me …
The mechanistic analysis comprises the experimental evaluation of the structure-reactivity relationship for a wide range of fumaramides [2]r …
Mutation screening of ACKR3 and COPS8 in kidney cancer cases from the CONFIRM study.
Mahmoodi M, Nguyen-Dumont T, Hammet F, Pope BJ, Park DJ, Southey MC, Darlow JM, Bruinsma F, Winship I. Mahmoodi M, et al. Fam Cancer. 2017 Jul;16(3):411-416. doi: 10.1007/s10689-016-9961-x. Fam Cancer. 2017. PMID: 28063109
While only synonymous variants were found in COPS8, one of the missense variants in ACKR3:c.892C>T, observed in 4/479 individuals screened (0.8%), was predicted likely to damage ACKR3 function. ...
While only synonymous variants were found in COPS8, one of the missense variants in ACKR3:c.892C>T, observed in 4/479 individuals …
Role of Fe(IV)-oxo intermediates in stoichiometric and catalytic oxidations mediated by iron pyridine-azamacrocycles.
Ye W, Ho DM, Friedle S, Palluccio TD, Rybak-Akimova EV. Ye W, et al. Inorg Chem. 2012 May 7;51(9):5006-21. doi: 10.1021/ic202435r. Epub 2012 Apr 25. Inorg Chem. 2012. PMID: 22534174
The electrophilic character of the (L1)Fe(IV)O intermediate was established in rapid (k(2) = 26.5 M(-1) s(-1) for oxidation of PPh(3) at 0 C), associative (deltaH() = 53 kJ/mol, deltaS() = -25 J/K mol) oxidation of substituted triarylphosphines (electron-donating substitue …
The electrophilic character of the (L1)Fe(IV)O intermediate was established in rapid (k(2) = 26.5 M(-1) s(-1) for oxidation of PPh(3) at 0 …
Is RNASEL:p.Glu265* a modifier of early-onset breast cancer risk for carriers of high-risk mutations?
Nguyen-Dumont T, Teo ZL, Hammet F, Roberge A, Mahmoodi M, Tsimiklis H, Park DJ, Pope BJ, Lonie A, Kapuscinski MK, Mahmood K; ABCFR, Goldgar DE, Giles GG, Winship I, Hopper JL, Southey MC. Nguyen-Dumont T, et al. BMC Cancer. 2018 Feb 8;18(1):165. doi: 10.1186/s12885-018-4028-z. BMC Cancer. 2018. PMID: 29422015 Free PMC article.
METHODS: In a family known to carry the high-risk mutation PALB2:c.3113G>A (p.Trp1038*), whole-exome sequencing was performed on germline DNA from four affected women, three of whom were mutation carriers. ...
METHODS: In a family known to carry the high-risk mutation PALB2:c.3113G>A (p.Trp1038*), whole-exome sequencing was performed on g …
Rare mutations in RINT1 predispose carriers to breast and Lynch syndrome-spectrum cancers.
Park DJ, Tao K, Le Calvez-Kelm F, Nguyen-Dumont T, Robinot N, Hammet F, Odefrey F, Tsimiklis H, Teo ZL, Thingholm LB, Young EL, Voegele C, Lonie A, Pope BJ, Roane TC, Bell R, Hu H, Shankaracharya, Huff CD, Ellis J, Li J, Makunin IV, John EM, Andrulis IL, Terry MB, Daly M, Buys SS, Snyder C, Lynch HT, Devilee P, Giles GG, Hopper JL, Feng BJ, Lesueur F, Tavtigian SV, Southey MC, Goldgar DE. Park DJ, et al. Cancer Discov. 2014 Jul;4(7):804-15. doi: 10.1158/2159-8290.CD-14-0212. Epub 2014 May 2. Cancer Discov. 2014. PMID: 25050558 Free PMC article.
A multiple-case breast cancer family exome-sequencing study identified three likely pathogenic mutations in RINT1 (NM_021930.4) not present in public sequencing databases: RINT1 c.343C>T (p.Q115X), c.1132_1134del (p.M378del), and c.1207G>T (p.D403Y). .. …
A multiple-case breast cancer family exome-sequencing study identified three likely pathogenic mutations in RINT1 (NM_021930.4) not present …
Synthesis, structure investigation, spectral characteristics and biological activities of some novel azodyes.
Zayed MA, Mohamed GG, Abdullah SA. Zayed MA, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Mar;78(3):1027-36. doi: 10.1016/j.saa.2010.12.037. Epub 2010 Dec 28. Spectrochim Acta A Mol Biomol Spectrosc. 2011. PMID: 21247792
Four novel azo compounds were synthesized; o-phenylazo- (C(14)H(13)N(3)O(2)) (I), p-bromo-o-phenylazo- (C(14)H(13)BrN(3)O(2)) (II), p-methoxy-o-phenaylazo- (C(15)H(16)N(3)O(3)) (III) and p-nitro-o-phenylazo-p-acetamidophenol (C(14)H(13)N(4)O(4)) (IV). …
Four novel azo compounds were synthesized; o-phenylazo- (C(14)H(13)N(3)O(2)) (I), p-bromo-o-phenylazo- (C(14)H(13)BrN(3)O(2)) …
FANCM and RECQL genetic variants and breast cancer susceptibility: relevance to South Poland and West Ukraine.
Nguyen-Dumont T, Myszka A, Karpinski P, Sasiadek MM, Akopyan H, Hammet F, Tsimiklis H, Park DJ, Pope BJ, Slezak R, Kitsera N, Siekierzynska A, Southey MC. Nguyen-Dumont T, et al. BMC Med Genet. 2018 Jan 19;19(1):12. doi: 10.1186/s12881-018-0524-x. BMC Med Genet. 2018. PMID: 29351780 Free PMC article.
RESULTS: Among 427 women screened, we identified one carrier of the FANCM:c.1972C > T nonsense mutation (0.23%), and two carriers of the frameshift insertion FANCM:c.1491dup (0.47%). ...Although initial reports suggesting that mutations in RECQL could be associat …
RESULTS: Among 427 women screened, we identified one carrier of the FANCM:c.1972C > T nonsense mutation (0.23%), and two carriers …
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