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Year Number of Results
2010 2
2011 2
2012 3
2013 8
2015 1
2016 1
2019 1
2021 1
2022 1
2023 1
2025 0

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20 results

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Page 1
Mapping the cellular origin and early evolution of leukemia in Down syndrome.
Wagenblast E, Araújo J, Gan OI, Cutting SK, Murison A, Krivdova G, Azkanaz M, McLeod JL, Smith SA, Gratton BA, Marhon SA, Gabra M, Medeiros JJF, Manteghi S, Chen J, Chan-Seng-Yue M, Garcia-Prat L, Salmena L, De Carvalho DD, Abelson S, Abdelhaleem M, Chong K, Roifman M, Shannon P, Wang JCY, Hitzler JK, Chitayat D, Dick JE, Lechman ER. Wagenblast E, et al. Science. 2021 Jul 9;373(6551):eabf6202. doi: 10.1126/science.abf6202. Science. 2021. PMID: 34244384
KDM6 demethylases integrate DNA repair gene regulation and loss of KDM6A sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition.
Boila LD, Ghosh S, Bandyopadhyay SK, Jin L, Murison A, Zeng AGX, Shaikh W, Bhowmik S, Muddineni SSNA, Biswas M, Sinha S, Chatterjee SS, Mbong N, Gan OI, Bose A, Chakraborty S, Arruda A, Kennedy JA, Mitchell A, Lechman ER, Banerjee D, Milyavsky M, Minden MD, Dick JE, Sengupta A. Boila LD, et al. Leukemia. 2023 Apr;37(4):751-764. doi: 10.1038/s41375-023-01833-z. Epub 2023 Jan 31. Leukemia. 2023. PMID: 36720973
Flow-Arrest Transitions in Frictional Granular Matter.
Srivastava I, Silbert LE, Grest GS, Lechman JB. Srivastava I, et al. Phys Rev Lett. 2019 Feb 1;122(4):048003. doi: 10.1103/PhysRevLett.122.048003. Phys Rev Lett. 2019. PMID: 30768335
The onset of arrest below critical shear stress occurs at a time t_{c} that exhibits a heavy-tailed distribution, whose mean and variance diverge as a power law at the critical shear stress with a friction-dependent exponent that also exhibits a crossover between low and h …
The onset of arrest below critical shear stress occurs at a time t_{c} that exhibits a heavy-tailed distribution, whose mean and vari …
Zebrafish microRNA-126 determines hematopoietic cell fate through c-Myb.
Grabher C, Payne EM, Johnston AB, Bolli N, Lechman E, Dick JE, Kanki JP, Look AT. Grabher C, et al. Leukemia. 2011 Mar;25(3):506-14. doi: 10.1038/leu.2010.280. Epub 2010 Nov 16. Leukemia. 2011. PMID: 21079614 Free PMC article.
In this study, we show that miR-126 is a novel physiological regulator of the proto-oncogene c-myb during definitive hematopoiesis. We show that knockdown of miR-126 results in increased c-Myb levels and promotes erythropoiesis at the expense of thrombopoiesis in vi …
In this study, we show that miR-126 is a novel physiological regulator of the proto-oncogene c-myb during definitive hematopoiesis. W …
PLAG1 dampens protein synthesis to promote human hematopoietic stem cell self-renewal.
Keyvani Chahi A, Belew MS, Xu J, Chen HTT, Rentas S, Voisin V, Krivdova G, Lechman E, Marhon SA, De Carvalho DD, Dick JE, Bader GD, Hope KJ. Keyvani Chahi A, et al. Blood. 2022 Sep 1;140(9):992-1008. doi: 10.1182/blood.2021014698. Blood. 2022. PMID: 35639948 Free PMC article.
Genome-wide measures of chromatin occupancy and PLAG1-directed gene expression changes combined with functional measures reveal that PLAG1 dampens protein synthesis, restrains cell growth and division, and enhances survival, with the primitive cell advantages it imparts being att …
Genome-wide measures of chromatin occupancy and PLAG1-directed gene expression changes combined with functional measures reveal that PLAG1 d …
miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells.
Lechman ER, Gentner B, Ng SW, Schoof EM, van Galen P, Kennedy JA, Nucera S, Ciceri F, Kaufmann KB, Takayama N, Dobson SM, Trotman-Grant A, Krivdova G, Elzinga J, Mitchell A, Nilsson B, Hermans KG, Eppert K, Marke R, Isserlin R, Voisin V, Bader GD, Zandstra PW, Golub TR, Ebert BL, Lu J, Minden M, Wang JC, Naldini L, Dick JE. Lechman ER, et al. Cancer Cell. 2016 Feb 8;29(2):214-28. doi: 10.1016/j.ccell.2015.12.011. Epub 2016 Jan 28. Cancer Cell. 2016. PMID: 26832662 Free PMC article.
Evaporation of Lennard-Jones fluids.
Cheng S, Lechman JB, Plimpton SJ, Grest GS. Cheng S, et al. J Chem Phys. 2011 Jun 14;134(22):224704. doi: 10.1063/1.3595260. J Chem Phys. 2011. PMID: 21682530
Our results indicate that for both monatomic and polyatomic molecules, the evaporation and condensation coefficients are equal when systems are not far from equilibrium and smaller than one, and decrease with increasing temperature. For the same reduced temperature T/T(c), …
Our results indicate that for both monatomic and polyatomic molecules, the evaporation and condensation coefficients are equal when systems …
Attenuation of miR-126 activity expands HSC in vivo without exhaustion.
Lechman ER, Gentner B, van Galen P, Giustacchini A, Saini M, Boccalatte FE, Hiramatsu H, Restuccia U, Bachi A, Voisin V, Bader GD, Dick JE, Naldini L. Lechman ER, et al. Cell Stem Cell. 2012 Dec 7;11(6):799-811. doi: 10.1016/j.stem.2012.09.001. Epub 2012 Nov 8. Cell Stem Cell. 2012. PMID: 23142521 Free PMC article.
Diffusion in Jammed Particle Packs.
Bolintineanu DS, Grest GS, Lechman JB, Silbert LE. Bolintineanu DS, et al. Phys Rev Lett. 2015 Aug 21;115(8):088002. doi: 10.1103/PhysRevLett.115.088002. Epub 2015 Aug 20. Phys Rev Lett. 2015. PMID: 26340211
The intermediate anomalous diffusion regime and the long-time value of the diffusion coefficient are both shown to be controlled by particle contacts, which in turn depend on proximity to (c). The time required to recover normal diffusion t* scales as (-(c))(-0.5) a …
The intermediate anomalous diffusion regime and the long-time value of the diffusion coefficient are both shown to be controlled by particle …
20 results