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Year Number of Results
1988 1
1991 1
1992 1
1993 1
1994 1
1998 1
1999 5
2000 3
2001 1
2002 3
2003 2
2004 2
2005 4
2006 5
2007 3
2008 2
2009 6
2010 5
2011 7
2012 6
2013 4
2014 14
2015 7
2016 16
2017 13
2018 15
2019 12
2020 18
2021 13
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148 results
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Page 1
Repurposed Antiviral Drugs for Covid-19 - Interim WHO Solidarity Trial Results.
WHO Solidarity Trial Consortium, Pan H, Peto R, Henao-Restrepo AM, Preziosi MP, Sathiyamoorthy V, Abdool Karim Q, Alejandria MM, Hernández García C, Kieny MP, Malekzadeh R, Murthy S, Reddy KS, Roses Periago M, Abi Hanna P, Ader F, Al-Bader AM, Alhasawi A, Allum E, Alotaibi A, Alvarez-Moreno CA, Appadoo S, Asiri A, Aukrust P, Barratt-Due A, Bellani S, Branca M, Cappel-Porter HBC, Cerrato N, Chow TS, Como N, Eustace J, García PJ, Godbole S, Gotuzzo E, Griskevicius L, Hamra R, Hassan M, Hassany M, Hutton D, Irmansyah I, Jancoriene L, Kirwan J, Kumar S, Lennon P, Lopardo G, Lydon P, Magrini N, Maguire T, Manevska S, Manuel O, McGinty S, Medina MT, Mesa Rubio ML, Miranda-Montoya MC, Nel J, Nunes EP, Perola M, Portolés A, Rasmin MR, Raza A, Rees H, Reges PPS, Rogers CA, Salami K, Salvadori MI, Sinani N, Sterne JAC, Stevanovikj M, Tacconelli E, Tikkinen KAO, Trelle S, Zaid H, Røttingen JA, Swaminathan S. WHO Solidarity Trial Consortium, et al. N Engl J Med. 2021 Feb 11;384(6):497-511. doi: 10.1056/NEJMoa2023184. Epub 2020 Dec 2. N Engl J Med. 2021. PMID: 33264556 Free PMC article. Clinical Trial.
Avelumab Maintenance Therapy for Advanced or Metastatic Urothelial Carcinoma.
Powles T, Park SH, Voog E, Caserta C, Valderrama BP, Gurney H, Kalofonos H, Radulović S, Demey W, Ullén A, Loriot Y, Sridhar SS, Tsuchiya N, Kopyltsov E, Sternberg CN, Bellmunt J, Aragon-Ching JB, Petrylak DP, Laliberte R, Wang J, Huang B, Davis C, Fowst C, Costa N, Blake-Haskins JA, di Pietro A, Grivas P. Powles T, et al. N Engl J Med. 2020 Sep 24;383(13):1218-1230. doi: 10.1056/NEJMoa2002788. Epub 2020 Sep 18. N Engl J Med. 2020. PMID: 32945632 Clinical Trial.
Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts.
Estruch R, Ros E, Salas-Salvadó J, Covas MI, Corella D, Arós F, Gómez-Gracia E, Ruiz-Gutiérrez V, Fiol M, Lapetra J, Lamuela-Raventos RM, Serra-Majem L, Pintó X, Basora J, Muñoz MA, Sorlí JV, Martínez JA, Fitó M, Gea A, Hernán MA, Martínez-González MA; PREDIMED Study Investigators. Estruch R, et al. N Engl J Med. 2018 Jun 21;378(25):e34. doi: 10.1056/NEJMoa1800389. Epub 2018 Jun 13. N Engl J Med. 2018. PMID: 29897866 Free article.
Infection prevention and control for labor and delivery, well baby nurseries, and neonatal intensive care units.
Saiman L, Acker KP, Dumitru D, Messina M, Johnson C, Zachariah P, Abreu W, Saslaw M, Keown MK, Hanft E, Liao G, Johnson D, Robinson K, Streltsova S, Valderrama N, Markan A, Rosado M, Krishnamurthy G, Sahni R, Penn AA, Sheen JJ, Zork N, Aubey J, Oxford-Horrey C, Goffman D. Saiman L, et al. Semin Perinatol. 2020 Nov;44(7):151320. doi: 10.1016/j.semperi.2020.151320. Epub 2020 Oct 12. Semin Perinatol. 2020. PMID: 33071033 Free PMC article.
During the early months of the COVID-19 pandemic, infection prevention and control (IP&C) for women in labor and mothers and newborns during delivery and receiving post-partum care was quite challenging for staff, patients, and support persons due to a relative lack of …
During the early months of the COVID-19 pandemic, infection prevention and control (IP&C) for women in labor and mothers and newb …
Tuning the Innate Immune Response to Cyclic Dinucleotides by Using Atomic Mutagenesis.
Li Y, Fin A, Rovira AR, Su Y, Dippel AB, Valderrama JA, Riestra AM, Nizet V, Hammond MC, Tor Y. Li Y, et al. Chembiochem. 2020 Sep 14;21(18):2595-2598. doi: 10.1002/cbic.202000162. Epub 2020 Jun 8. Chembiochem. 2020. PMID: 32346955 Free PMC article.
Herein, we report the design and immunostimulatory effect of a novel group of c-di-GMP analogues. By employing an "atomic mutagenesis" strategy, changing one atom at a time, a class of gradually modified CDNs was prepared. These c-di-GMP analogues induce type-I inte …
Herein, we report the design and immunostimulatory effect of a novel group of c-di-GMP analogues. By employing an "atomic mutagenesis …
Supporting and sustaining centralized reminder/recall for immunizations: Qualitative insights from stakeholders.
Fisher MP, Gurfinkel D, Szilagyi PG, Saville A, Albertin C, Breck A, Valderrama R, Kempe A. Fisher MP, et al. Vaccine. 2019 Oct 16;37(44):6601-6608. doi: 10.1016/j.vaccine.2019.09.055. Epub 2019 Sep 24. Vaccine. 2019. PMID: 31562003 Free PMC article.
IISs are usually based in state public health departments, which could initiate C-R/R. While C-R/R is a promising strategy, the factors influencing its initiation and sustainment are not clear. ...We identified and spoke with managers and senior leaders across IISs, …
IISs are usually based in state public health departments, which could initiate C-R/R. While C-R/R is a promising strategy, th …
Pyrrolomycins Are Potent Natural Protonophores.
Valderrama K, Pradel E, Firsov AM, Drobecq H, Bauderlique-le Roy H, Villemagne B, Antonenko YN, Hartkoorn RC. Valderrama K, et al. Antimicrob Agents Chemother. 2019 Sep 23;63(10):e01450-19. doi: 10.1128/AAC.01450-19. Print 2019 Oct. Antimicrob Agents Chemother. 2019. PMID: 31405863 Free PMC article.
Using potentiometric probes and an electrophysiological technique with an artificial bilayer lipid membrane, it was demonstrated that pyrrolomycins C and D are very potent membrane-depolarizing agents, an order of magnitude more active than conventional carbonyl cyanide m- …
Using potentiometric probes and an electrophysiological technique with an artificial bilayer lipid membrane, it was demonstrated that pyrrol …
Synthesis and antitumor evaluation of 6-aryl-substituted benzo[j]phenanthridine- and benzo[g]pyrimido[4,5-c]isoquinolinequinones.
Iribarra J, Vásquez D, Theoduloz C, Benites J, Ríos D, Valderrama JA. Iribarra J, et al. Molecules. 2012 Sep 28;17(10):11616-29. doi: 10.3390/molecules171011616. Molecules. 2012. PMID: 23023687 Free PMC article.
A variety of novel 6-arylsubstituted benzo[j]phenanthridine- and benzo[g]-pyrimido[4,5-c]isoquinolinequinones were synthesized from 1,4-naphthoquinone, aryl-aldehydes and enaminones via a two-step synthetic approach. ...
A variety of novel 6-arylsubstituted benzo[j]phenanthridine- and benzo[g]-pyrimido[4,5-c]isoquinolinequinones were synthesized from 1 …
Gaps between research and recommendations in rheumatoid arthritis.
Ortiz AM, Silva Fernández L, Villaverde V, Abad MÁ, Maneiro JR, Candelas G, Gómez S, Valderrama M, Montoro M. Ortiz AM, et al. Rheumatol Int. 2021 Jan;41(1):57-66. doi: 10.1007/s00296-020-04724-z. Epub 2020 Oct 20. Rheumatol Int. 2021. PMID: 33079230 Review.
They identified all recommendations with a low level of evidence or recommendation grade (levels equivalent to 4, 5, or grades C or D of the Oxford Levels of Evidence), classified them by areas (diagnosis, follow-up, treatment, others), and analyzed plausible causes of low …
They identified all recommendations with a low level of evidence or recommendation grade (levels equivalent to 4, 5, or grades C or D …
148 results