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Year Number of Results
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2009 15
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2011 14
2012 10
2013 14
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382 results

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Page 1
Showing results for cancer dincer
Search for Caner Dincer instead (1 results)
Novel WRN Helicase Inhibitors Selectively Target Microsatellite-Unstable Cancer Cells.
Picco G, Rao Y, Al Saedi A, Lee Y, Vieira SF, Bhosle S, May K, Herranz-Ors C, Walker SJ, Shenje R, Dincer C, Gibson F, Banerjee R, Hewitson Z, Werner T, Cottom JE, Peng Y, Deng N, Zhang Y, Nartey EN, Nickels L, Landis P, Conticelli D, McCarten K, Bush J, Sharma M, Lightfoot H, House D, Milford E, Grant EK, Glogowski MP, Wagner CD, Bantscheff M, Rutkowska-Klute A; Cell Model Network UK Group; Zappacosta F, Pettinger J, Barthorpe S, Eberl HC, Jones BT, Schneck JL, Murphy DJ, Voest EE, Taygerly JP, DeMartino MP, Coelho MA, Houseley J, Sharma G, Schwartz B, Garnett MJ. Picco G, et al. Cancer Discov. 2024 Aug 2;14(8):1457-1475. doi: 10.1158/2159-8290.CD-24-0052. Cancer Discov. 2024. PMID: 38587317 Free PMC article.
Microsatellite-unstable (MSI) cancers require WRN helicase to resolve replication stress due to expanded DNA (TA)n dinucleotide repeats. ...These findings pave the way to translate WRN inhibition into MSI cancer therapies and provide tools to investigate WRN biology …
Microsatellite-unstable (MSI) cancers require WRN helicase to resolve replication stress due to expanded DNA (TA)n dinucleotide repea …
Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial.
Davies C, Pan H, Godwin J, Gray R, Arriagada R, Raina V, Abraham M, Medeiros Alencar VH, Badran A, Bonfill X, Bradbury J, Clarke M, Collins R, Davis SR, Delmestri A, Forbes JF, Haddad P, Hou MF, Inbar M, Khaled H, Kielanowska J, Kwan WH, Mathew BS, Mittra I, Müller B, Nicolucci A, Peralta O, Pernas F, Petruzelka L, Pienkowski T, Radhika R, Rajan B, Rubach MT, Tort S, Urrútia G, Valentini M, Wang Y, Peto R; Adjuvant Tamoxifen: Longer Against Shorter (ATLAS) Collaborative Group. Davies C, et al. Lancet. 2013 Mar 9;381(9869):805-16. doi: 10.1016/S0140-6736(12)61963-1. Lancet. 2013. PMID: 23219286 Free PMC article. Clinical Trial.
BACKGROUND: For women with oestrogen receptor (ER)-positive early breast cancer, treatment with tamoxifen for 5 years substantially reduces the breast cancer mortality rate throughout the first 15 years after diagnosis. ...After entry (between 1996 and 2005), yearly …
BACKGROUND: For women with oestrogen receptor (ER)-positive early breast cancer, treatment with tamoxifen for 5 years substantially r …
Base editing screens map mutations affecting interferon-gamma signaling in cancer.
Coelho MA, Cooper S, Strauss ME, Karakoc E, Bhosle S, Gonçalves E, Picco G, Burgold T, Cattaneo CM, Veninga V, Consonni S, Dinçer C, Vieira SF, Gibson F, Barthorpe S, Hardy C, Rein J, Thomas M, Marioni J, Voest EE, Bassett A, Garnett MJ. Coelho MA, et al. Cancer Cell. 2023 Feb 13;41(2):288-303.e6. doi: 10.1016/j.ccell.2022.12.009. Epub 2023 Jan 19. Cancer Cell. 2023. PMID: 36669486 Free PMC article.
Mutations in the IFN-gamma signaling pathway cause immunological disorders, hematological malignancies, and resistance to immune checkpoint blockade (ICB) in cancer; however, the function of most clinically observed variants remains unknown. Here, we systematically investi …
Mutations in the IFN-gamma signaling pathway cause immunological disorders, hematological malignancies, and resistance to immune checkpoint …
Base editing screens define the genetic landscape of cancer drug resistance mechanisms.
Coelho MA, Strauss ME, Watterson A, Cooper S, Bhosle S, Illuzzi G, Karakoc E, Dinçer C, Vieira SF, Sharma M, Moullet M, Conticelli D, Koeppel J, McCarten K, Cattaneo CM, Veninga V, Picco G, Parts L, Forment JV, Voest EE, Marioni JC, Bassett A, Garnett MJ. Coelho MA, et al. Nat Genet. 2024 Nov;56(11):2479-2492. doi: 10.1038/s41588-024-01948-8. Epub 2024 Oct 18. Nat Genet. 2024. PMID: 39424923 Free PMC article.
Drug resistance is a principal limitation to the long-term efficacy of cancer therapies. Cancer genome sequencing can retrospectively delineate the genetic basis of drug resistance, but this requires large numbers of post-treatment samples to nominate causal variant …
Drug resistance is a principal limitation to the long-term efficacy of cancer therapies. Cancer genome sequencing can retrospe …
SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.
COVIDSurg Collaborative, GlobalSurg Collaborative. COVIDSurg Collaborative, GlobalSurg Collaborative. Br J Surg. 2021 Sep 27;108(9):1056-1063. doi: 10.1093/bjs/znab101. Br J Surg. 2021. PMID: 33761533 Free PMC article.
The most favourable NNVs were in patients aged 70 years or more needing cancer surgery (351; best case 196, worst case 816) or non-cancer surgery (733; best case 407, worst case 1664). ...
The most favourable NNVs were in patients aged 70 years or more needing cancer surgery (351; best case 196, worst case 816) or non- …
Capivasertib plus abiraterone in PTEN-deficient metastatic hormone-sensitive prostate cancer: CAPItello-281 phase III study.
Fizazi K, Clarke NW, De Santis M, Uemura H, Fay AP, Karadurmus N, Kwiatkowski M, Alvarez-Fernandez C, Jiang S, Sotelo M, Parslow D, Oliveira N, Kwon TG, Ye D, Boudewijns S, Danchaivijitr P, Rooney C, Gresty C, Yeste-Velasco M, Logan J, George DJ; CAPItello-281 Study Group. Fizazi K, et al. Ann Oncol. 2026 Jan;37(1):53-68. doi: 10.1016/j.annonc.2025.10.004. Epub 2025 Oct 19. Ann Oncol. 2026. PMID: 41120017 Free article. Clinical Trial.
BACKGROUND: In metastatic hormone-sensitive prostate cancer (mHSPC), phosphatase and tensin homolog (PTEN) deficiency results in phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway activation, providing an independent proliferative drive, which cannot be suppre …
BACKGROUND: In metastatic hormone-sensitive prostate cancer (mHSPC), phosphatase and tensin homolog (PTEN) deficiency results in phos …
The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study.
COVIDSurg Collaborative. COVIDSurg Collaborative. Colorectal Dis. 2022 Mar 14;24(6):708-26. doi: 10.1111/codi.16117. Online ahead of print. Colorectal Dis. 2022. PMID: 35286766 Free PMC article.
AIM: The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. ...Longer delays …
AIM: The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This …
Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study.
COVIDSurg Collaborative. COVIDSurg Collaborative. Lancet Oncol. 2021 Nov;22(11):1507-1517. doi: 10.1016/S1470-2045(21)00493-9. Epub 2021 Oct 5. Lancet Oncol. 2021. PMID: 34624250 Free PMC article. Clinical Trial.
BACKGROUND: Surgery is the main modality of cure for solid cancers and was prioritised to continue during COVID-19 outbreaks. This study aimed to identify immediate areas for system strengthening by comparing the delivery of elective cancer surgery during the COVID- …
BACKGROUND: Surgery is the main modality of cure for solid cancers and was prioritised to continue during COVID-19 outbreaks. This st …
Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma.
Wang JZ, Patil V, Landry AP, Gui C, Ajisebutu A, Liu J, Saarela O, Pugh SL, Won M, Patel Z, Yakubov R, Kaloti R, Wilson C, Cohen-Gadol A, Zaazoue MA, Tabatabai G, Tatagiba M, Behling F, Almiron Bonnin DA, Holland EC, Kruser TJ, Barnholtz-Sloan JS, Sloan AE, Horbinski C, Chotai S, Chambless LB, Gao A, Rebchuk AD, Makarenko S, Yip S, Sahm F, Maas SLN, Tsang DS; International Consortium on Meningiomas (ICOM); Rogers CL, Aldape K, Nassiri F, Zadeh G. Wang JZ, et al. Nat Med. 2024 Nov;30(11):3173-3183. doi: 10.1038/s41591-024-03167-4. Epub 2024 Aug 21. Nat Med. 2024. PMID: 39169220 Free PMC article.
Death following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic.
STARSurg Collaborative and COVIDSurg Collaborative. STARSurg Collaborative and COVIDSurg Collaborative. Br J Surg. 2021 Dec 1;108(12):1448-1464. doi: 10.1093/bjs/znab336. Br J Surg. 2021. PMID: 34871379 Free PMC article.
Both included patients undergoing elective resection of an intra-abdominal cancer with curative intent across five surgical oncology disciplines. Patient selection and rates of 30-day postoperative pulmonary complications were compared. ...
Both included patients undergoing elective resection of an intra-abdominal cancer with curative intent across five surgical oncology …
382 results