Cardioprotective effects of extracellular vesicles from hypoxia-preconditioned mesenchymal stromal cells in experimental pulmonary arterial hypertension.
Santos RT, Braga CL, de Sá Freire Onofre ME, da Silva CM, de Novaes Rocha N, Veras RG, de Souza Serra SS, Teixeira DE, Dos Santos Alves SA, Miranda BT, Pereira MG, Neves CC, de Oliveira Garcia MR, Takiya CM, Rocco PRM, Cruz FF, Silva PL.
Santos RT, et al.
Stem Cell Res Ther. 2025 Aug 29;16(1):466. doi: 10.1186/s13287-025-04604-y.
Stem Cell Res Ther. 2025.
PMID: 40877897
Free PMC article.
Only EV-H increased PAT/PET, reduced RV outflow diameter, and the RVH index compared with PAH-SAL. The expressions of c-Myc, a marker of myocardial injury, and p-GSK3beta-Ser9, a proliferative marker, were higher in the PAH-SAL group than in the CTRL group. EV-N and EV-H d …
Only EV-H increased PAT/PET, reduced RV outflow diameter, and the RVH index compared with PAH-SAL. The expressions of c-Myc, a marker …