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Sorafenib resistance in hepatocarcinoma: role of hypoxia-inducible factors.

Méndez-Blanco C, Fondevila F, García-Palomo A, González-Gallego J, Mauriz JL. Méndez-Blanco C, et al. Exp Mol Med. 2018 Oct 12;50(10):1-9. doi: 10.1038/s12276-018-0159-1. Exp Mol Med. 2018. PMID: 30315182 Free PMC article. Review.

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Melatonin as an Antitumor Agent against Liver Cancer: An Updated Systematic Review.

Fernández-Palanca P, Méndez-Blanco C, Fondevila F, Tuñón MJ, Reiter RJ, Mauriz JL, González-Gallego J. Fernández-Palanca P, et al. Among authors: mendez blanco c. Antioxidants (Basel). 2021 Jan 12;10(1):103. doi: 10.3390/antiox10010103. Antioxidants (Basel). 2021. PMID: 33445767 Free PMC article. Review.

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Autophagy-Related Chemoprotection against Sorafenib in Human Hepatocarcinoma: Role of FOXO3 Upregulation and Modulation by Regorafenib.

Fondevila F, Méndez-Blanco C, Fernández-Palanca P, Payo-Serafín T, van Pelt J, Verslype C, González-Gallego J, Mauriz JL. Fondevila F, et al. Among authors: mendez blanco c. Int J Mol Sci. 2021 Oct 29;22(21):11770. doi: 10.3390/ijms222111770. Int J Mol Sci. 2021. PMID: 34769197 Free PMC article.

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Association of FOXO3 Expression with Tumor Pathogenesis, Prognosis and Clinicopathological Features in Hepatocellular Carcinoma: A Systematic Review with Meta-Analysis.

Fondevila F, Fernández-Palanca P, Méndez-Blanco C, Payo-Serafín T, Lozano E, Marin JJG, González-Gallego J, Mauriz JL. Fondevila F, et al. Among authors: mendez blanco c. Cancers (Basel). 2021 Oct 26;13(21):5349. doi: 10.3390/cancers13215349. Cancers (Basel). 2021. PMID: 34771514 Free PMC article. Review.

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Anti-tumoral activity of single and combined regorafenib treatments in preclinical models of liver and gastrointestinal cancers.

Fondevila F, Méndez-Blanco C, Fernández-Palanca P, González-Gallego J, Mauriz JL. Fondevila F, et al. Among authors: mendez blanco c. Exp Mol Med. 2019 Sep 24;51(9):1-15. doi: 10.1038/s12276-019-0308-1. Exp Mol Med. 2019. PMID: 31551425 Free PMC article. Review.

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Prognostic and clinicopathological significance of hypoxia-inducible factors 1α and 2α in hepatocellular carcinoma: a systematic review with meta-analysis.

Méndez-Blanco C, Fernández-Palanca P, Fondevila F, González-Gallego J, Mauriz JL. Méndez-Blanco C, et al. Ther Adv Med Oncol. 2021 Feb 7;13:1758835920987071. doi: 10.1177/1758835920987071. eCollection 2021. Ther Adv Med Oncol. 2021. PMID: 33613697 Free PMC article.

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Antitumor Effects of Quercetin in Hepatocarcinoma In Vitro and In Vivo Models: A Systematic Review.

Fernández-Palanca P, Fondevila F, Méndez-Blanco C, Tuñón MJ, González-Gallego J, Mauriz JL. Fernández-Palanca P, et al. Among authors: mendez blanco c. Nutrients. 2019 Nov 25;11(12):2875. doi: 10.3390/nu11122875. Nutrients. 2019. PMID: 31775362 Free PMC article.

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Stabilization of Hypoxia-Inducible Factors and BNIP3 Promoter Methylation Contribute to Acquired Sorafenib Resistance in Human Hepatocarcinoma Cells.

Méndez-Blanco C, Fondevila F, Fernández-Palanca P, García-Palomo A, Pelt JV, Verslype C, González-Gallego J, Mauriz JL. Méndez-Blanco C, et al. Cancers (Basel). 2019 Dec 9;11(12):1984. doi: 10.3390/cancers11121984. Cancers (Basel). 2019. PMID: 31835431 Free PMC article.

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Melatonin enhances sorafenib actions in human hepatocarcinoma cells by inhibiting mTORC1/p70S6K/HIF-1α and hypoxia-mediated mitophagy.

Prieto-Domínguez N, Méndez-Blanco C, Carbajo-Pescador S, Fondevila F, García-Palomo A, González-Gallego J, Mauriz JL. Prieto-Domínguez N, et al. Among authors: mendez blanco c. Oncotarget. 2017 Aug 24;8(53):91402-91414. doi: 10.18632/oncotarget.20592. eCollection 2017 Oct 31. Oncotarget. 2017. PMID: 29207653 Free PMC article.

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Melatonin-induced increase in sensitivity of human hepatocellular carcinoma cells to sorafenib is associated with reactive oxygen species production and mitophagy.

Prieto-Domínguez N, Ordóñez R, Fernández A, Méndez-Blanco C, Baulies A, Garcia-Ruiz C, Fernández-Checa JC, Mauriz JL, González-Gallego J. Prieto-Domínguez N, et al. Among authors: mendez blanco c. J Pineal Res. 2016 Oct;61(3):396-407. doi: 10.1111/jpi.12358. Epub 2016 Aug 19. J Pineal Res. 2016. PMID: 27484637 Free PMC article.

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