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2017 2
2018 1
2020 0
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Proteolysis of mature HIV-1 p6 Gag protein by the insulin-degrading enzyme (IDE) regulates virus replication in an Env-dependent manner.
Hahn F, Schmalen A, Setz C, Friedrich M, Schlößer S, Kölle J, Spranger R, Rauch P, Fraedrich K, Reif T, Karius-Fischer J, Balasubramanyam A, Henklein P, Fossen T, Schubert U. Hahn F, et al. Among authors: setz c. PLoS One. 2017 Apr 7;12(4):e0174254. doi: 10.1371/journal.pone.0174254. eCollection 2017. PLoS One. 2017. PMID: 28388673 Free PMC article. Clinical Trial.
The N-Terminus of the HIV-1 p6 Gag Protein Regulates Susceptibility to Degradation by IDE.
Schmalen A, Karius-Fischer J, Rauch P, Setz C, Korn K, Henklein P, Fossen T, Schubert U. Schmalen A, et al. Among authors: setz c. Viruses. 2018 Dec 12;10(12):710. doi: 10.3390/v10120710. Viruses. 2018. PMID: 30545091 Free PMC article.
Glutamic Acid Residues in HIV-1 p6 Regulate Virus Budding and Membrane Association of Gag.
Friedrich M, Setz C, Hahn F, Matthaei A, Fraedrich K, Rauch P, Henklein P, Traxdorf M, Fossen T, Schubert U. Friedrich M, et al. Among authors: setz c. Viruses. 2016 Apr 25;8(4):117. doi: 10.3390/v8040117. Viruses. 2016. PMID: 27120610 Free PMC article.
Just one position-independent lysine residue can direct MelanA into proteasomal degradation following N-terminal fusion of ubiquitin.
Setz C, Friedrich M, Hahn S, Dörrie J, Schaft N, Schuler G, Schubert U. Setz C, et al. PLoS One. 2013;8(2):e55567. doi: 10.1371/journal.pone.0055567. Epub 2013 Feb 5. PLoS One. 2013. PMID: 23393593 Free PMC article.
Mutation of the highly conserved Ser-40 of the HIV-1 p6 gag protein to Phe causes the formation of a hydrophobic patch, enhances membrane association, and polyubiquitination of Gag.
Hahn F, Setz C, Friedrich M, Rauch P, Solbak SM, Frøystein NA, Henklein P, Votteler J, Fossen T, Schubert U. Hahn F, et al. Among authors: setz c. Viruses. 2014 Oct 2;6(10):3738-65. doi: 10.3390/v6103738. Viruses. 2014. PMID: 25279819 Free PMC article.
The PTAP sequence within the p6 domain of human immunodeficiency virus type 1 Gag regulates its ubiquitination and MHC class I antigen presentation.
Hahn S, Setz C, Wild J, Schubert U. Hahn S, et al. Among authors: setz c. J Immunol. 2011 May 15;186(10):5706-18. doi: 10.4049/jimmunol.1003764. Epub 2011 Apr 11. J Immunol. 2011. PMID: 21482733 Free article.
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