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Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms.

Pinkosky SL, Scott JW, Desjardins EM, Smith BK, Day EA, Ford RJ, Langendorf CG, Ling NXY, Nero TL, Loh K, Galic S, Hoque A, Smiles WJ, Ngoei KRW, Parker MW, Yan Y, Melcher K, Kemp BE, Oakhill JS, Steinberg GR. Pinkosky SL, et al. Among authors: langendorf cg. Nat Metab. 2020 Sep;2(9):873-881. doi: 10.1038/s42255-020-0245-2. Epub 2020 Jul 27. Nat Metab. 2020. PMID: 32719536 Free PMC article.

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mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress.

Ling NXY, Kaczmarek A, Hoque A, Davie E, Ngoei KRW, Morrison KR, Smiles WJ, Forte GM, Wang T, Lie S, Dite TA, Langendorf CG, Scott JW, Oakhill JS, Petersen J. Ling NXY, et al. Among authors: langendorf cg. Nat Metab. 2020 Jan;2(1):41-49. doi: 10.1038/s42255-019-0157-1. Epub 2020 Jan 20. Nat Metab. 2020. PMID: 31993556 Free PMC article.

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New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology.

Rosdah AA, Smiles WJ, Oakhill JS, Scott JW, Langendorf CG, Delbridge LMD, Holien JK, Lim SY. Rosdah AA, et al. Among authors: langendorf cg. Pharmacol Ther. 2020 Sep;213:107594. doi: 10.1016/j.pharmthera.2020.107594. Epub 2020 May 29. Pharmacol Ther. 2020. PMID: 32473962 Review.

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CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins.

Langendorf CG, O'Brien MT, Ngoei KRW, McAloon LM, Dhagat U, Hoque A, Ling NXY, Dite TA, Galic S, Loh K, Parker MW, Oakhill JS, Kemp BE, Scott JW. Langendorf CG, et al. J Biol Chem. 2020 Nov 27;295(48):16239-16250. doi: 10.1074/jbc.RA120.013756. Epub 2020 Sep 9. J Biol Chem. 2020. PMID: 32913128 Free article.

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In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds.

O'Byrne SN, Scott JW, Pilotte JR, Santiago ADS, Langendorf CG, Oakhill JS, Eduful BJ, Couñago RM, Wells CI, Zuercher WJ, Willson TM, Drewry DH. O'Byrne SN, et al. Among authors: langendorf cg. Molecules. 2020 Jan 13;25(2):325. doi: 10.3390/molecules25020325. Molecules. 2020. PMID: 31941153 Free PMC article.

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Fake Inhibitors: AMPK Activation Trumps Inhibition.

Langendorf CG, Scott JW, Kemp BE. Langendorf CG, et al. Cell Chem Biol. 2017 Jul 20;24(7):775-777. doi: 10.1016/j.chembiol.2017.07.005. Cell Chem Biol. 2017. PMID: 28732195 Free article.

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Protein kinase A negatively regulates VEGF-induced AMPK activation by phosphorylating CaMKK2 at serine 495.

Spengler K, Zibrova D, Woods A, Langendorf CG, Scott JW, Carling D, Heller R. Spengler K, et al. Among authors: langendorf cg. Biochem J. 2020 Sep 18;477(17):3453-3469. doi: 10.1042/BCJ20200555. Biochem J. 2020. PMID: 32869834

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Choreography of AMPK activation.

Langendorf CG, Kemp BE. Langendorf CG, et al. Cell Res. 2015 Jan;25(1):5-6. doi: 10.1038/cr.2014.163. Epub 2014 Dec 5. Cell Res. 2015. PMID: 25475061 Free PMC article.

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Functional analysis of an R311C variant of Ca²⁺ -calmodulin-dependent protein kinase kinase-2 (CaMKK2) found as a de novo mutation in a patient with bipolar disorder.

Xy Ling N, Langendorf CG, Hoque A, Galic S, Loh K, Kemp BE, Gundlach AL, Oakhill JS, Scott JW. Xy Ling N, et al. Among authors: langendorf cg. Bipolar Disord. 2020 Dec;22(8):841-848. doi: 10.1111/bdi.12901. Epub 2020 Apr 9. Bipolar Disord. 2020. PMID: 32216002

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The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs.

Dite TA, Ling NXY, Scott JW, Hoque A, Galic S, Parker BL, Ngoei KRW, Langendorf CG, O'Brien MT, Kundu M, Viollet B, Steinberg GR, Sakamoto K, Kemp BE, Oakhill JS. Dite TA, et al. Among authors: langendorf cg. Nat Commun. 2017 Sep 18;8(1):571. doi: 10.1038/s41467-017-00628-y. Nat Commun. 2017. PMID: 28924239 Free PMC article.

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