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Page 1
Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice.
Smith CM, Baker RE, Proulx MK, Mishra BB, Long JE, Park SW, Lee HN, Kiritsy MC, Bellerose MM, Olive AJ, Murphy KC, Papavinasasundaram K, Boehm FJ, Reames CJ, Meade RK, Hampton BK, Linnertz CL, Shaw GD, Hock P, Bell TA, Ehrt S, Schnappinger D, Pardo-Manuel de Villena F, Ferris MT, Ioerger TR, Sassetti CM. Smith CM, et al. Elife. 2022 Feb 3;11:e74419. doi: 10.7554/eLife.74419. Elife. 2022. PMID: 35112666 Free PMC article.
Cathepsin Z is a conserved susceptibility factor underlying tuberculosis severity.
Meade RK, Adefisayo OO, Gontijo MTP, Harris SJ, Pyle CJ, Wilburn KM, Ecker AMV, Hughes EJ, Garcia PD, Ivie J, McHenry ML, Benchek PH, Mayanja-Kizza H, Neff JL, Ko DC, Stout JE, Stein CM, Hawn TR, Tobin DM, Smith CM. Meade RK, et al. Among authors: smith cm. PLoS Biol. 2025 Sep 9;23(9):e3003377. doi: 10.1371/journal.pbio.3003377. eCollection 2025 Sep. PLoS Biol. 2025. PMID: 40924769 Free PMC article.
Host eicosanoid signals define a granuloma fibroblast population that coordinates mycobacterial containment.
Hughes EJ, Pyle CJ, Chambers M, Travnickova J, Mpotje T, Lowy JP, Strang NT, Carranza CE, Ohman HKE, Naidoo T, Wang L, Ko DC, Neff JL, Gregory SG, Smith CM, Stout JE, Lih FB, Edin ML, Zeldin DC, Patton EE, Marakalala MJ, Leslie A, Tobin DM. Hughes EJ, et al. Among authors: smith cm. Cell Host Microbe. 2026 Sep 9;34(9):1795-1813.e7. doi: 10.1016/j.chom.2026.07.019. Epub 2026 Aug 25. Cell Host Microbe. 2026. PMID: 42641606 Free PMC article.
High-quality mouse reference genomes reveal the structural complexity of the murine protein-coding landscape.
Helmy M, Li JU, Yan XF, Meade RK, Anderson E, Chen PB, Czechanski AM, Di Domenico T, Flint J, Garrison E, Gontijo MTP, Guarracino A, Haggerty L, Heard E, Howe K, Meena N, Martin FJ, Miska EA, Rall I, Ramakrishna NB, Sapetschnig A, Sinha S, Sun D, Tricomi FF, Qu R, Wood JMD, Wu T, Zhou DJ, Reinholdt L, Adams DJ, Smith CM, Lilue J, Keane TM. Helmy M, et al. Among authors: smith cm. Cell Genom. 2026 Feb 11;6(2):101074. doi: 10.1016/j.xgen.2025.101074. Epub 2025 Dec 1. Cell Genom. 2026. PMID: 41330379 Free PMC article.
An ancestral mycobacterial effector promotes dissemination of infection.
Saelens JW, Sweeney MI, Viswanathan G, Xet-Mull AM, Jurcic Smith KL, Sisk DM, Hu DD, Cronin RM, Hughes EJ, Brewer WJ, Coers J, Champion MM, Champion PA, Lowe CB, Smith CM, Lee S, Stout JE, Tobin DM. Saelens JW, et al. Among authors: smith cm. Cell. 2022 Nov 23;185(24):4507-4525.e18. doi: 10.1016/j.cell.2022.10.019. Epub 2022 Nov 9. Cell. 2022. PMID: 36356582 Free PMC article.
38 results