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Inhibition of class C beta-lactamases: structure of a reaction intermediate with a cephem sulfone.

Crichlow GV, Nukaga M, Doppalapudi VR, Buynak JD, Knox JR. Crichlow GV, et al. Biochemistry. 2001 May 29;40(21):6233-9. doi: 10.1021/bi010131s. Biochemistry. 2001. PMID: 11371184

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RCSB Protein Data Bank: powerful new tools for exploring 3D structures of biological macromolecules for basic and applied research and education in fundamental biology, biomedicine, biotechnology, bioengineering and energy sciences.

Burley SK, Bhikadiya C, Bi C, Bittrich S, Chen L, Crichlow GV, Christie CH, Dalenberg K, Di Costanzo L, Duarte JM, Dutta S, Feng Z, Ganesan S, Goodsell DS, Ghosh S, Green RK, Guranović V, Guzenko D, Hudson BP, Lawson CL, Liang Y, Lowe R, Namkoong H, Peisach E, Persikova I, Randle C, Rose A, Rose Y, Sali A, Segura J, Sekharan M, Shao C, Tao YP, Voigt M, Westbrook JD, Young JY, Zardecki C, Zhuravleva M. Burley SK, et al. Among authors: crichlow gv. Nucleic Acids Res. 2021 Jan 8;49(D1):D437-D451. doi: 10.1093/nar/gkaa1038. Nucleic Acids Res. 2021. PMID: 33211854 Free PMC article.

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RCSB Protein Data Bank: Celebrating 50 years of the PDB with new tools for understanding and visualizing biological macromolecules in 3D.

Burley SK, Bhikadiya C, Bi C, Bittrich S, Chen L, Crichlow GV, Duarte JM, Dutta S, Fayazi M, Feng Z, Flatt JW, Ganesan SJ, Goodsell DS, Ghosh S, Kramer Green R, Guranovic V, Henry J, Hudson BP, Lawson CL, Liang Y, Lowe R, Peisach E, Persikova I, Piehl DW, Rose Y, Sali A, Segura J, Sekharan M, Shao C, Vallat B, Voigt M, Westbrook JD, Whetstone S, Young JY, Zardecki C. Burley SK, et al. Among authors: crichlow gv. Protein Sci. 2022 Jan;31(1):187-208. doi: 10.1002/pro.4213. Epub 2021 Nov 6. Protein Sci. 2022. PMID: 34676613

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Unraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60.

Hsiao HT, Crichlow GV, Murphy JW, Folta-Stogniew EJ, Lolis EJ, Braddock DT. Hsiao HT, et al. Among authors: crichlow gv. PLoS One. 2020 Nov 30;15(11):e0242725. doi: 10.1371/journal.pone.0242725. eCollection 2020. PLoS One. 2020. PMID: 33253191 Free PMC article.

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Protein crystallization facilitated by molecularly imprinted polymers.

Saridakis E, Khurshid S, Govada L, Phan Q, Hawkins D, Crichlow GV, Lolis E, Reddy SM, Chayen NE. Saridakis E, et al. Among authors: crichlow gv. Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11081-6. doi: 10.1073/pnas.1016539108. Epub 2011 Jun 20. Proc Natl Acad Sci U S A. 2011. PMID: 21690356 Free PMC article.

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Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast.

Cho Y, Crichlow GV, Vermeire JJ, Leng L, Du X, Hodsdon ME, Bucala R, Cappello M, Gross M, Gaeta F, Johnson K, Lolis EJ. Cho Y, et al. Among authors: crichlow gv. Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11313-8. doi: 10.1073/pnas.1002716107. Epub 2010 Jun 8. Proc Natl Acad Sci U S A. 2010. PMID: 20534506 Free PMC article.

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ISO-66, a novel inhibitor of macrophage migration, shows efficacy in melanoma and colon cancer models.

Ioannou K, Cheng KF, Crichlow GV, Birmpilis AI, Lolis EJ, Tsitsilonis OE, Al-Abed Y. Ioannou K, et al. Among authors: crichlow gv. Int J Oncol. 2014 Oct;45(4):1457-68. doi: 10.3892/ijo.2014.2551. Epub 2014 Jul 22. Int J Oncol. 2014. PMID: 25050663 Free PMC article.

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Dimerization of FIR upon FUSE DNA binding suggests a mechanism of c-myc inhibition.

Crichlow GV, Zhou H, Hsiao HH, Frederick KB, Debrosse M, Yang Y, Folta-Stogniew EJ, Chung HJ, Fan C, De la Cruz EM, Levens D, Lolis E, Braddock D. Crichlow GV, et al. EMBO J. 2008 Jan 9;27(1):277-89. doi: 10.1038/sj.emboj.7601936. Epub 2007 Dec 6. EMBO J. 2008. PMID: 18059478 Free PMC article.

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Structural interactions dictate the kinetics of macrophage migration inhibitory factor inhibition by different cancer-preventive isothiocyanates.

Crichlow GV, Fan C, Keeler C, Hodsdon M, Lolis EJ. Crichlow GV, et al. Biochemistry. 2012 Sep 25;51(38):7506-14. doi: 10.1021/bi3005494. Epub 2012 Sep 11. Biochemistry. 2012. PMID: 22931430 Free PMC article.

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Structural and kinetic analyses of macrophage migration inhibitory factor active site interactions.

Crichlow GV, Lubetsky JB, Leng L, Bucala R, Lolis EJ. Crichlow GV, et al. Biochemistry. 2009 Jan 13;48(1):132-9. doi: 10.1021/bi8014423. Biochemistry. 2009. PMID: 19090677 Free PMC article.

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