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Showing results for D. scit
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EAACI Guidelines on Allergen Immunotherapy: Allergic rhinoconjunctivitis.
Roberts G, Pfaar O, Akdis CA, Ansotegui IJ, Durham SR, Gerth van Wijk R, Halken S, Larenas-Linnemann D, Pawankar R, Pitsios C, Sheikh A, Worm M, Arasi S, Calderon MA, Cingi C, Dhami S, Fauquert JL, Hamelmann E, Hellings P, Jacobsen L, Knol EF, Lin SY, Maggina P, Mösges R, Oude Elberink JNG, Pajno GB, Pastorello EA, Penagos M, Rotiroti G, Schmidt-Weber CB, Timmermans F, Tsilochristou O, Varga EM, Wilkinson JN, Williams A, Zhang L, Agache I, Angier E, Fernandez-Rivas M, Jutel M, Lau S, van Ree R, Ryan D, Sturm GJ, Muraro A. Roberts G, et al. Allergy. 2018 Apr;73(4):765-798. doi: 10.1111/all.13317. Epub 2017 Oct 30. Allergy. 2018. PMID: 28940458
Allergen immunotherapy (AIT) represents the only currently available treatment that targets the underlying pathophysiology, and it may have a disease-modifying effect. Either the subcutaneous (SCIT) or sublingual (SLIT) routes may be used. This Guideline has been prepared …
Allergen immunotherapy (AIT) represents the only currently available treatment that targets the underlying pathophysiology, and it may have …
Cluster protocols in SCIT: enough evidence for practical use?
Pfaar O, Leitzbach S, Hörmann K, Klimek L. Pfaar O, et al. Curr Opin Allergy Clin Immunol. 2010 Jun;10(3):188-93. doi: 10.1097/ACI.0b013e328339505c. Curr Opin Allergy Clin Immunol. 2010. PMID: 20410818 Review.
In accelerated cluster schedules two to three injections are administered sequentially per treatment day (with an interval of 30 min between the injections) in weekly intervals aimed to reach the maintenance dose of SCIT in a short time interval. Recent studies indicate th …
In accelerated cluster schedules two to three injections are administered sequentially per treatment day (with an interval of 30 min between …
Vitamin D as an adjunct to subcutaneous allergen immunotherapy in asthmatic children sensitized to house dust mite.
Baris S, Kiykim A, Ozen A, Tulunay A, Karakoc-Aydiner E, Barlan IB. Baris S, et al. Allergy. 2014 Feb;69(2):246-53. doi: 10.1111/all.12278. Epub 2013 Nov 4. Allergy. 2014. PMID: 24180595 Clinical Trial.
RESULTS: In the SCIT + vitamin D and SCIT alone groups, total asthma symptom score (TASS), total symptom score (TSS), and total medication scores (TMS) were significantly lower than pharmacotherapy group at the end of 1 year. ...Whereas the levels of Der p 1- …
RESULTS: In the SCIT + vitamin D and SCIT alone groups, total asthma symptom score (TASS), total symptom score (TSS), a …
Clinical aspects of sublingual immunotherapy tablets and drops.
Tankersley M, Han JK, Nolte H. Tankersley M, et al. Ann Allergy Asthma Immunol. 2020 Jun;124(6):573-582. doi: 10.1016/j.anai.2019.12.025. Epub 2020 Jan 7. Ann Allergy Asthma Immunol. 2020. PMID: 31923544 Review.
BACKGROUND: Sublingual immunotherapy (SLIT) is administered via tablets (SLIT-T) or liquid drops (SLIT-D). In North America, currently 4 SLIT-T formulations are approved by the US Food and Drug Administration for allergy immunotherapy, and SLIT-D is an off-label use …
BACKGROUND: Sublingual immunotherapy (SLIT) is administered via tablets (SLIT-T) or liquid drops (SLIT-D). In North America, currentl …
High dose vitamin D3 empowers effects of subcutaneous immunotherapy in a grass pollen-driven mouse model of asthma.
Hesse L, van Ieperen N, Petersen AH, Elberink JNGO, van Oosterhout AJM, Nawijn MC. Hesse L, et al. Sci Rep. 2020 Nov 30;10(1):20876. doi: 10.1038/s41598-020-77947-6. Sci Rep. 2020. PMID: 33257771 Free PMC article.
GP-sensitized BALBc/ByJ mice received three SCIT injections of VitD3-GP (30, 100, and 300 ng or placebo). Separately, synthetic lipids, SAINT, was added to the VitD3-GP-SCIT formulation (300 nmol) and control groups. ...Addition of VitD3 further decreased Th2 cytoki …
GP-sensitized BALBc/ByJ mice received three SCIT injections of VitD3-GP (30, 100, and 300 ng or placebo). Separately, synthetic lipid …
Guideline on allergen-specific immunotherapy in IgE-mediated allergic diseases: S2k Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the Society for Pediatric Allergy and Environmental Medicine (GPA), the Medical Association of German Allergologists (AeDA), the Austrian Society for Allergy and Immunology (ÖGAI), the Swiss Society for Allergy and Immunology (SGAI), the German Society of Dermatology (DDG), the German Society of Oto- Rhino-Laryngology, Head and Neck Surgery (DGHNO-KHC), the German Society of Pediatrics and Adolescent Medicine (DGKJ), the Society for Pediatric Pneumology (GPP), the German Respiratory Society (DGP), the German Association of ENT Surgeons (BV-HNO), the Professional Federation of Paediatricians and Youth Doctors (BVKJ), the Federal Association of Pulmonologists (BDP) and the German Dermatologists Association (BVDD).
Pfaar O, Bachert C, Bufe A, Buhl R, Ebner C, Eng P, Friedrichs F, Fuchs T, Hamelmann E, Hartwig-Bade D, Hering T, Huttegger I, Jung K, Klimek L, Kopp MV, Merk H, Rabe U, Saloga J, Schmid-Grendelmeier P, Schuster A, Schwerk N, Sitter H, Umpfenbach U, Wedi B, Wöhrl S, Worm M, Kleine-Tebbe J, Kaul S, Schwalfenberg A. Pfaar O, et al. Allergo J Int. 2014;23(8):282-319. doi: 10.1007/s40629-014-0032-2. Allergo J Int. 2014. PMID: 26120539 Free PMC article.
Severe, potentially life-threatening systemic reactions during SCIT are possible, but - providing all safety measures are adhered to - these events are very rare. ...Systemic reactions have been described in SLIT, but are seen far less often than with SCIT. In terms …
Severe, potentially life-threatening systemic reactions during SCIT are possible, but - providing all safety measures are adhered to …
Serum Level of IL 10 is Significantly Increased in Allergic Rhinitis Patients on Subcutaneous Immunotherapy and Vitamin D Supplementation.
El-Maghraby HM, Rabie RA. El-Maghraby HM, et al. Egypt J Immunol. 2019 Jul;26(2):87-93. Egypt J Immunol. 2019. PMID: 31926498
Objective of this study was to assess role of Vitamin D supplementation with SCIT in inducing tolerance to pollen, increasing IL10 and improving symptoms in AR patients. 48 AR patients were included. ...In conclusion, serum level of IL 10 is significantly increased …
Objective of this study was to assess role of Vitamin D supplementation with SCIT in inducing tolerance to pollen, increasing …
Allergen immunotherapy now and in the future.
Nelson HS. Nelson HS. Allergy Asthma Proc. 2016 Jul;37(4):268-72. doi: 10.2500/aap.2016.37.3966. Allergy Asthma Proc. 2016. PMID: 27401313 Review.
BACKGROUND: Subcutaneous (SCIT) and sublingual (SLIT) immunotherapy provide effective treatment for allergic rhinitis and allergic asthma with clinical improvement following an adequate course of therapy persisting in most patients for years after treatment is discontinued …
BACKGROUND: Subcutaneous (SCIT) and sublingual (SLIT) immunotherapy provide effective treatment for allergic rhinitis and allergic as …
A randomized, 5-arm dose finding study with a mite allergoid SCIT in allergic rhinoconjunctivitis patients.
Pfaar O, Nell MJ, Boot JD, Versteeg SA, van Ree R, Roger A, Riechelmann H, Sperl A, Oude Elberink JN, Diamant Z, Bachert C. Pfaar O, et al. Allergy. 2016 Jul;71(7):967-76. doi: 10.1111/all.12860. Epub 2016 Mar 29. Allergy. 2016. PMID: 26864207 Clinical Trial.
METHODS: In total, 290 adult ARC patients (148 females; 142 males) with established HDM allergy and with a positive TNPT were randomized to receive placebo or mite allergoid SCIT 6667, 20 000, 50 000 or 100 000 AUeq/ml for 12 months. Patients were updosed weekly, followed …
METHODS: In total, 290 adult ARC patients (148 females; 142 males) with established HDM allergy and with a positive TNPT were randomized to …
Social cognition and interaction training for recent-onset schizophrenia: A preliminary randomized trial.
Rocha NB, Campos C, Figueiredo JM, Saraiva S, Almeida C, Moreira C, Pereira G, Telles-Correia D, Roberts D. Rocha NB, et al. Early Interv Psychiatry. 2021 Feb;15(1):206-212. doi: 10.1111/eip.12944. Epub 2020 Feb 12. Early Interv Psychiatry. 2021. PMID: 32052567 Clinical Trial.
Permutation-based analysis revealed improvements in overall functioning (P = 0.036) and blame score (P = 0.070) in the SCIT group compared to the psychoeducation intervention, with large effect sizes (d = 1.438 and d = 1.204, respectively). There were also la …
Permutation-based analysis revealed improvements in overall functioning (P = 0.036) and blame score (P = 0.070) in the SCIT group com …
67 results