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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 1
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1975 4
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1978 3
1979 5
1980 9
1981 11
1982 14
1983 16
1984 11
1985 9
1986 13
1987 15
1988 21
1989 33
1990 28
1991 27
1992 26
1993 22
1994 37
1995 34
1996 29
1997 32
1998 24
1999 30
2000 26
2001 30
2002 39
2003 43
2004 22
2005 27
2006 36
2007 38
2008 44
2009 28
2010 24
2011 47
2012 36
2013 41
2014 27
2015 34
2016 46
2017 48
2018 35
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2022 40
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1,364 results

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Page 1
Total Syntheses of (-)-Deoxoapodine, (-)-Kopsifoline D, and (-)-Beninine.
Zhou YG, Wong HNC, Peng XS. Zhou YG, et al. J Org Chem. 2020 Jan 17;85(2):967-976. doi: 10.1021/acs.joc.9b02918. Epub 2019 Dec 26. J Org Chem. 2020. PMID: 31830791
Corey-Bakshi-Shibata reduction was employed to afford the enantioenriched intermediate for the total syntheses of the aforementioned alkaloids. ...The enantioselective total syntheses of (-)-kopsifoline D and (-)-beninine were accomplished for the first time. Our st …
Corey-Bakshi-Shibata reduction was employed to afford the enantioenriched intermediate for the total syntheses of the aforementioned …
Aspartate racemase and D-aspartate in starfish; possible involvement in testicular maturation.
Shibata K, Sugaya N, Kuboki Y, Matsuda H, Abe K, Takahashi S, Kera Y. Shibata K, et al. Biosci Biotechnol Biochem. 2020 Jan;84(1):95-102. doi: 10.1080/09168451.2019.1660614. Epub 2019 Sep 3. Biosci Biotechnol Biochem. 2020. PMID: 31478781
D-Aspartate, aspartate racemase activity, and D-aspartate oxidase activity were detected in tissues from several types of starfish. ...However, such changes were not observed in female ovaries. Administration of D-aspartate into male starfish caused testicula …
D-Aspartate, aspartate racemase activity, and D-aspartate oxidase activity were detected in tissues from several types of star …
In Silico Design, Synthesis, and Evaluation of PROTAC Against Hematopoietic Prostaglandin D Synthase.
Yokoo H, Shibata N, Demizu Y. Yokoo H, et al. Methods Mol Biol. 2024;2780:345-359. doi: 10.1007/978-1-0716-3985-6_18. Methods Mol Biol. 2024. PMID: 38987477
This chapter describes in silico design of a hematopoietic prostaglandin D synthase (H-PGDS) degrader, PROTAC(H-PGDS), using a docking simulation of the ternary complex of H-PGDS/PROTAC/E3 ligase as well as the synthesis of the designed PROTAC(H-PGDS)s and evaluation of th …
This chapter describes in silico design of a hematopoietic prostaglandin D synthase (H-PGDS) degrader, PROTAC(H-PGDS), using a dockin …
Obstructive and secretory complications of diverting ileostomy.
Tsujinaka S, Suzuki H, Miura T, Sato Y, Shibata C. Tsujinaka S, et al. World J Gastroenterol. 2022 Dec 21;28(47):6732-6742. doi: 10.3748/wjg.v28.i47.6732. World J Gastroenterol. 2022. PMID: 36620340 Free PMC article. Review.
The incidence of HOS is 14%-24%, with an output of 1000-2000 mL/d lasting up to three days. Treatment of HOS is commenced after excluding postoperative complications or enteritis and includes fluid intake restriction, antimotility and antisecretory drug therapies, and magn …
The incidence of HOS is 14%-24%, with an output of 1000-2000 mL/d lasting up to three days. Treatment of HOS is commenced after exclu …
Development of an enzymatic screening method for d-aspartate-producing lactic acid bacteria.
Kajitani K, Ishikawa T, Shibata K, Kouya T, Kera Y, Takahashi S. Kajitani K, et al. Enzyme Microb Technol. 2021 Sep;149:109835. doi: 10.1016/j.enzmictec.2021.109835. Epub 2021 Jun 5. Enzyme Microb Technol. 2021. PMID: 34311880
d-Aspartate (d-Asp) is an important intermediate for synthetic penicillin and an endogenous amino acid that plays important roles in the endocrine and nervous systems in animals including humans. Lactic acid bacteria (LABs) have been used as probiotics in humans, an …
d-Aspartate (d-Asp) is an important intermediate for synthetic penicillin and an endogenous amino acid that plays important ro …
Homology recognition without double-stranded DNA-strand separation in D-loop formation by RecA.
Shibata T, Ikawa S, Iwasaki W, Sasanuma H, Masai H, Hirota K. Shibata T, et al. Nucleic Acids Res. 2024 Mar 21;52(5):2565-2577. doi: 10.1093/nar/gkad1260. Nucleic Acids Res. 2024. PMID: 38214227 Free PMC article.
RecA protein and RecA/Rad51 orthologues are required for homologous recombination and DNA repair in all living creatures. RecA/Rad51 catalyzes formation of the D-loop, an obligatory recombination intermediate, through an ATP-dependent reaction consisting of two phases: hom …
RecA protein and RecA/Rad51 orthologues are required for homologous recombination and DNA repair in all living creatures. RecA/Rad51 catalyz …
Development of a Hematopoietic Prostaglandin D Synthase-Degradation Inducer.
Yokoo H, Shibata N, Naganuma M, Murakami Y, Fujii K, Ito T, Aritake K, Naito M, Demizu Y. Yokoo H, et al. ACS Med Chem Lett. 2021 Jan 14;12(2):236-241. doi: 10.1021/acsmedchemlett.0c00605. eCollection 2021 Feb 11. ACS Med Chem Lett. 2021. PMID: 33603969 Free PMC article.
Although hematopoietic prostaglandin D synthase (H-PGDS) is an attractive target for treatment of a variety of diseases, including allergic diseases and Duchenne muscular dystrophy, no H-PGDS inhibitors have yet been approved for treatment of these diseases. ...PROTAC(H-PG …
Although hematopoietic prostaglandin D synthase (H-PGDS) is an attractive target for treatment of a variety of diseases, including al …
25(OH)D(3) stimulates the expression of vitamin D target genes in renal tubular cells when Cyp27b1 is abrogated.
Kikuyama T, Susa T, Tamamori-Adachi M, Iizuka M, Akimoto M, Okinaga H, Fujigaki Y, Uchida S, Shibata S, Okazaki T. Kikuyama T, et al. J Steroid Biochem Mol Biol. 2020 May;199:105593. doi: 10.1016/j.jsbmb.2020.105593. Epub 2020 Jan 13. J Steroid Biochem Mol Biol. 2020. PMID: 31945466
Recently, it was reported that 25(OH)D(3) (25D3) has physiological bioactivity in certain tissues derived from Cyp27b1 knockout mice. ...A chromatin immunoprecipitation assay identified two vitamin D response elements in the upstream region of the megalin gene that …
Recently, it was reported that 25(OH)D(3) (25D3) has physiological bioactivity in certain tissues derived from Cyp27b1 knockout mice. …
1,364 results