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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1876 1
1883 1
1893 1
1902 1
1911 1
1918 1
1933 1
1934 1
1936 1
1938 1
1942 1
1945 10
1946 27
1947 30
1948 48
1949 34
1950 45
1951 171
1952 296
1953 365
1954 413
1955 349
1956 374
1957 385
1958 313
1959 157
1960 3
1961 5
1962 8
1963 71
1964 143
1965 494
1966 624
1967 737
1968 877
1969 919
1970 962
1971 909
1972 1054
1973 918
1974 975
1975 1279
1976 1283
1977 1277
1978 1297
1979 1433
1980 1385
1981 1542
1982 1693
1983 1846
1984 2005
1985 2016
1986 2385
1987 2669
1988 3314
1989 3925
1990 4339
1991 4324
1992 4630
1993 4698
1994 5089
1995 5224
1996 5266
1997 5720
1998 6034
1999 6590
2000 6977
2001 7705
2002 8671
2003 9186
2004 9561
2005 10408
2006 10773
2007 11121
2008 11595
2009 12209
2010 12840
2011 13205
2012 13583
2013 14880
2014 18560
2015 20990
2016 23346
2017 24497
2018 24977
2019 24310
2020 24872
2021 24417
2022 22746
2023 14485
2024 19

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423,349 results

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Page 1
Outwitting EF-Tu and the ribosome: translation with d-amino acids.
Achenbach J, Jahnz M, Bethge L, Paal K, Jung M, Schuster M, Albrecht R, Jarosch F, Nierhaus KH, Klussmann S. Achenbach J, et al. Nucleic Acids Res. 2015 Jul 13;43(12):5687-98. doi: 10.1093/nar/gkv566. Epub 2015 May 30. Nucleic Acids Res. 2015. PMID: 26026160 Free PMC article.
Key components of the translational apparatus, i.e. ribosomes, elongation factor EF-Tu and most aminoacyl-tRNA synthetases, are stereoselective and prevent incorporation of d-amino acids (d-aa) into polypeptides. ...We introduce an in vitro translation system …
Key components of the translational apparatus, i.e. ribosomes, elongation factor EF-Tu and most aminoacyl-tRNA synthetases, are stere …
Vitamin-D-resistant rickets.
MITCHELL FN, MITCHELL JE. MITCHELL FN, et al. AMA J Dis Child. 1957 Apr;93(4):385-90. doi: 10.1001/archpedi.1957.02060040387005. AMA J Dis Child. 1957. PMID: 13410374 No abstract available.
Kinetics of d-Amino Acid Incorporation in Translation.
Liljeruhm J, Wang J, Kwiatkowski M, Sabari S, Forster AC. Liljeruhm J, et al. ACS Chem Biol. 2019 Feb 15;14(2):204-213. doi: 10.1021/acschembio.8b00952. Epub 2019 Jan 16. ACS Chem Biol. 2019. PMID: 30648860
Incorporation was moderately hastened by tRNA body swaps and higher EF-Tu concentrations, indicating that binding by EF-Tu can be rate-limiting. However, from tRNA(AlaB) with a saturating concentration of EF-Tu, the slow d-Phe incorporation was unexpec …
Incorporation was moderately hastened by tRNA body swaps and higher EF-Tu concentrations, indicating that binding by EF-Tu can …
Interaction of helix D of elongation factor Tu with helices 4 and 5 of protein L7/12 on the ribosome.
Kothe U, Wieden HJ, Mohr D, Rodnina MV. Kothe U, et al. J Mol Biol. 2004 Mar 5;336(5):1011-21. doi: 10.1016/j.jmb.2003.12.080. J Mol Biol. 2004. PMID: 15037065
Elongation factor Tu (EF-Tu) promotes binding of aminoacyl-tRNA to the A site of the ribosome. Here, we report the effects of mutations in helix D of EF-Tu and in the C-terminal domain of L7/12 on the kinetics of A-site binding. ...
Elongation factor Tu (EF-Tu) promotes binding of aminoacyl-tRNA to the A site of the ribosome. Here, we report the effects of …
Tenatoprazole. Benatoprazole, TU 199.
[No authors listed] [No authors listed] Drugs R D. 2002;3(4):276-7. doi: 10.2165/00126839-200203040-00009. Drugs R D. 2002. PMID: 12455204 Review. No abstract available.
Ribosomal incorporation of negatively charged d-α- and N-methyl-l-α-amino acids enhanced by EF-Sep.
Katoh T, Suga H. Katoh T, et al. Philos Trans R Soc Lond B Biol Sci. 2023 Feb 27;378(1871):20220038. doi: 10.1098/rstb.2022.0038. Epub 2023 Jan 11. Philos Trans R Soc Lond B Biol Sci. 2023. PMID: 36633283
Ribosomal incorporation of d-alpha-amino acids (dAA) and N-methyl-l-alpha-amino acids ((Me)AA) with negatively charged sidechains, such as d-Asp, d-Glu, (Me)Asp and (Me)Glu, into nascent peptides is far more inefficient compared to those with neutral or posit …
Ribosomal incorporation of d-alpha-amino acids (dAA) and N-methyl-l-alpha-amino acids ((Me)AA) with negatively charged sidechains, su …
The Future of AD Clinical Trials with the Advent of Anti-Amyloid Therapies: An CTAD Task Force Report.
Delrieu J, Bateman RJ, Touchon J, Sabbagh M, Cummings J. Delrieu J, et al. J Prev Alzheimers Dis. 2022;9(3):393-399. doi: 10.14283/jpad.2022.48. J Prev Alzheimers Dis. 2022. PMID: 35841240
These changes will promote the selection of patients in clinical trials by amyloid and tau biomarkers that identify patients with appropriate biology and may follow the treatment response to approved amyloid antibodies. The use of these agents creates the opportunity to te …
These changes will promote the selection of patients in clinical trials by amyloid and tau biomarkers that identify patients with appropriat …
Duplication of Drosophila melanogaster mitochondrial EF-Tu: pre-adaptation to T-arm truncation and exclusion of bulky aminoacyl residues.
Sato A, Suematsu T, Aihara KK, Kita K, Suzuki T, Watanabe K, Ohtsuki T, Watanabe YI. Sato A, et al. Biochem J. 2017 Mar 7;474(6):957-969. doi: 10.1042/BCJ20160929. Biochem J. 2017. PMID: 28130490
Translation elongation factor Tu (EF-Tu) delivers aminoacyl-tRNA (aa-tRNA) to ribosomes in protein synthesis. ...Both D. melanogaster EF-Tu1 and EF-Tu2 bound to cloverleaf and D-armless tRNAs. ...
Translation elongation factor Tu (EF-Tu) delivers aminoacyl-tRNA (aa-tRNA) to ribosomes in protein synthesis. ...Both D …
Preclinical trials in autosomal dominant AD: implementation of the DIAN-TU trial.
Mills SM, Mallmann J, Santacruz AM, Fuqua A, Carril M, Aisen PS, Althage MC, Belyew S, Benzinger TL, Brooks WS, Buckles VD, Cairns NJ, Clifford D, Danek A, Fagan AM, Farlow M, Fox N, Ghetti B, Goate AM, Heinrichs D, Hornbeck R, Jack C, Jucker M, Klunk WE, Marcus DS, Martins RN, Masters CM, Mayeux R, McDade E, Morris JC, Oliver A, Ringman JM, Rossor MN, Salloway S, Schofield PR, Snider J, Snyder P, Sperling RA, Stewart C, Thomas RG, Xiong C, Bateman RJ. Mills SM, et al. Rev Neurol (Paris). 2013 Oct;169(10):737-43. doi: 10.1016/j.neurol.2013.07.017. Epub 2013 Sep 6. Rev Neurol (Paris). 2013. PMID: 24016464 Free PMC article. Review.
The Dominantly Inherited Alzheimer's Network Trials Unit (DIAN-TU) was formed to direct the design and management of interventional therapeutic trials of international DIAN and autosomal dominant Alzheimer's disease (ADAD) participants. The goal of the DIAN-TU …
The Dominantly Inherited Alzheimer's Network Trials Unit (DIAN-TU) was formed to direct the design and management of interventional …
[The new S3-guideline gestational diabetes].
Hummel M. Hummel M. MMW Fortschr Med. 2018 Nov;160(19):64-66. doi: 10.1007/s15006-018-1091-y. MMW Fortschr Med. 2018. PMID: 30406526 Review. German. No abstract available.
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