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1985 1
1999 2
2000 1
2009 1
2010 1
2011 1
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2014 3
2015 2
2016 2
2017 4
2018 2
2019 2
2020 1
2021 2
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Page 1
Multi-ethnic genome-wide association study for atrial fibrillation.
Roselli C, Chaffin MD, Weng LC, Aeschbacher S, Ahlberg G, Albert CM, Almgren P, Alonso A, Anderson CD, Aragam KG, Arking DE, Barnard J, Bartz TM, Benjamin EJ, Bihlmeyer NA, Bis JC, Bloom HL, Boerwinkle E, Bottinger EB, Brody JA, Calkins H, Campbell A, Cappola TP, Carlquist J, Chasman DI, Chen LY, Chen YI, Choi EK, Choi SH, Christophersen IE, Chung MK, Cole JW, Conen D, Cook J, Crijns HJ, Cutler MJ, Damrauer SM, Daniels BR, Darbar D, Delgado G, Denny JC, Dichgans M, Dörr M, Dudink EA, Dudley SC, Esa N, Esko T, Eskola M, Fatkin D, Felix SB, Ford I, Franco OH, Geelhoed B, Grewal RP, Gudnason V, Guo X, Gupta N, Gustafsson S, Gutmann R, Hamsten A, Harris TB, Hayward C, Heckbert SR, Hernesniemi J, Hocking LJ, Hofman A, Horimoto ARVR, Huang J, Huang PL, Huffman J, Ingelsson E, Ipek EG, Ito K, Jimenez-Conde J, Johnson R, Jukema JW, Kääb S, Kähönen M, Kamatani Y, Kane JP, Kastrati A, Kathiresan S, Katschnig-Winter P, Kavousi M, Kessler T, Kietselaer BL, Kirchhof P, Kleber ME, Knight S, Krieger JE, Kubo M, Launer LJ, Laurikka J, Lehtimäki T, Leineweber K, Lemaitre RN, Li M, Lim HE, Lin HJ, Lin H, Lind L, Lindgren CM, Lokki ML, London B, Loos RJF, Low SK, Lu Y, Lyytikäinen LP, Macfarlane PW, Magnusson PK, Mahajan A, Malik R, Mansur AJ, Marcus GM, Margolin L, Margulies KB, März W, McManus DD, Melander O, Mohanty S, Montgomery JA, Morley MP, Morris AP, Müller-Nurasyid M, Natale A, Nazarian S, Neumann B, Newton-Cheh C, Niemeijer MN, Nikus K, Nilsson P, Noordam R, Oellers H, Olesen MS, Orho-Melander M, Padmanabhan S, Pak HN, Paré G, Pedersen NL, Pera J, Pereira A, Porteous D, Psaty BM, Pulit SL, Pullinger CR, Rader DJ, Refsgaard L, Ribasés M, Ridker PM, Rienstra M, Risch L, Roden DM, Rosand J, Rosenberg MA, Rost N, Rotter JI, Saba S, Sandhu RK, Schnabel RB, Schramm K, Schunkert H, Schurman C, Scott SA, Seppälä I, Shaffer C, Shah S, Shalaby AA, Shim J, Shoemaker MB, Siland JE, Sinisalo J, Sinner MF, Slowik A, Smith AV, Smith BH, Smith JG, Smith JD, Smith NL, Soliman EZ, Sotoodehnia N, Stricker BH, Sun A, Sun H, Svendsen JH, Tanaka T, Tanriverdi K, Taylor KD, Teder-Laving M, Teumer A, Thériault S, Trompet S, Tucker NR, Tveit A, Uitterlinden AG, Van Der Harst P, Van Gelder IC, Van Wagoner DR, Verweij N, Vlachopoulou E, Völker U, Wang B, Weeke PE, Weijs B, Weiss R, Weiss S, Wells QS, Wiggins KL, Wong JA, Woo D, Worrall BB, Yang PS, Yao J, Yoneda ZT, Zeller T, Zeng L, Lubitz SA, Lunetta KL, Ellinor PT. Roselli C, et al. Nat Genet. 2018 Jun 11;50(9):1225-1233. doi: 10.1038/s41588-018-0133-9. Nat Genet. 2018. PMID: 29892015 Free PMC article.
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
Lee JJ, Wedow R, Okbay A, Kong E, Maghzian O, Zacher M, Nguyen-Viet TA, Bowers P, Sidorenko J, Karlsson Linnér R, Fontana MA, Kundu T, Lee C, Li H, Li R, Royer R, Timshel PN, Walters RK, Willoughby EA, Yengo L; 23andMe Research Team; COGENT (Cognitive Genomics Consortium); Social Science Genetic Association Consortium, Alver M, Bao Y, Clark DW, Day FR, Furlotte NA, Joshi PK, Kemper KE, Kleinman A, Langenberg C, Mägi R, Trampush JW, Verma SS, Wu Y, Lam M, Zhao JH, Zheng Z, Boardman JD, Campbell H, Freese J, Harris KM, Hayward C, Herd P, Kumari M, Lencz T, Luan J, Malhotra AK, Metspalu A, Milani L, Ong KK, Perry JRB, Porteous DJ, Ritchie MD, Smart MC, Smith BH, Tung JY, Wareham NJ, Wilson JF, Beauchamp JP, Conley DC, Esko T, Lehrer SF, Magnusson PKE, Oskarsson S, Pers TH, Robinson MR, Thom K, Watson C, Chabris CF, Meyer MN, Laibson DI, Yang J, Johannesson M, Koellinger PD, Turley P, Visscher PM, Benjamin DJ, Cesarini D. Lee JJ, et al. Nat Genet. 2018 Jul 23;50(8):1112-1121. doi: 10.1038/s41588-018-0147-3. Nat Genet. 2018. PMID: 30038396 Free PMC article.
Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.
Salloway S, Sperling R, Fox NC, Blennow K, Klunk W, Raskind M, Sabbagh M, Honig LS, Porsteinsson AP, Ferris S, Reichert M, Ketter N, Nejadnik B, Guenzler V, Miloslavsky M, Wang D, Lu Y, Lull J, Tudor IC, Liu E, Grundman M, Yuen E, Black R, Brashear HR; Bapineuzumab 301 and 302 Clinical Trial Investigators. Salloway S, et al. N Engl J Med. 2014 Jan 23;370(4):322-33. doi: 10.1056/NEJMoa1304839. N Engl J Med. 2014. PMID: 24450891 Free PMC article. Clinical Trial.
BACKGROUND: Bapineuzumab, a humanized anti-amyloid-beta monoclonal antibody, is in clinical development for the treatment of Alzheimer's disease. METHODS: We conducted two double-blind, randomized, placebo-controlled, phase 3 trials involving patients with mild-to-moderate …
BACKGROUND: Bapineuzumab, a humanized anti-amyloid-beta monoclonal antibody, is in clinical development for the treatment of Alzheimer's
Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9.
Schmidt AF, Holmes MV, Preiss D, Swerdlow DI, Denaxas S, Fatemifar G, Faraway R, Finan C, Valentine D, Fairhurst-Hunter Z, Hartwig FP, Horta BL, Hypponen E, Power C, Moldovan M, van Iperen E, Hovingh K, Demuth I, Norman K, Steinhagen-Thiessen E, Demuth J, Bertram L, Lill CM, Coassin S, Willeit J, Kiechl S, Willeit K, Mason D, Wright J, Morris R, Wanamethee G, Whincup P, Ben-Shlomo Y, McLachlan S, Price JF, Kivimaki M, Welch C, Sanchez-Galvez A, Marques-Vidal P, Nicolaides A, Panayiotou AG, Onland-Moret NC, van der Schouw YT, Matullo G, Fiorito G, Guarrera S, Sacerdote C, Wareham NJ, Langenberg C, Scott RA, Luan J, Bobak M, Malyutina S, Pająk A, Kubinova R, Tamosiunas A, Pikhart H, Grarup N, Pedersen O, Hansen T, Linneberg A, Jess T, Cooper J, Humphries SE, Brilliant M, Kitchner T, Hakonarson H, Carrell DS, McCarty CA, Lester KH, Larson EB, Crosslin DR, de Andrade M, Roden DM, Denny JC, Carty C, Hancock S, Attia J, Holliday E, Scott R, Schofield P, O'Donnell M, Yusuf S, Chong M, Pare G, van der Harst P, Said MA, Eppinga RN, Verweij N, Snieder H; Lifelines Cohort authors, Christen T, Mook-Kanamori DO; ICBP Consortium, Gustafsson S, Lind L, Ingelsson E, Pazoki R, Franco O, Hofman A, Uitterlinden A, Dehghan A, Teumer A, Baumeister S, Dörr M, Lerch MM, Völker U, Völzke H, Ward J, Pell JP, Meade T, Christophersen IE, Maitland-van der Zee AH, Baranova EV, Young R, Ford I, Campbell A, Padmanabhan S, Bots ML, Grobbee DE, Froguel P, Thuillier D, Roussel R, Bonnefond A, Cariou B, Smart M, Bao Y, Kumari M, Mahajan A, Hopewell JC, Seshadri S; METASTROKE Consortium of the ISGC, Dale C, Costa RPE, Ridker PM, Chasman DI, Reiner AP, Ritchie MD, Lange LA, Cornish AJ, Dobbins SE, Hemminki K, Kinnersley B, Sanson M, Labreche K, Simon M, Bondy M, Law P, Speedy H, Allan J, Li N, Went M, Weinhold N, Morgan G, Sonneveld P, Nilsson B, Goldschmidt H, Sud A, Engert A, Hansson M, Hemingway H, Asselbergs FW, Patel RS, Keating BJ, Sattar N, Houlston R, Casas JP, Hingorani AD. Schmidt AF, et al. BMC Cardiovasc Disord. 2019 Oct 29;19(1):240. doi: 10.1186/s12872-019-1187-z. BMC Cardiovasc Disord. 2019. PMID: 31664920 Free PMC article.
No genetic associations were observed for cancer, heart failure, atrial fibrillation, chronic obstructive pulmonary disease, or Alzheimer's disease - outcomes for which large-scale trial data were unavailable. ...
No genetic associations were observed for cancer, heart failure, atrial fibrillation, chronic obstructive pulmonary disease, or Alzheimer' …
Lipid-related markers and cardiovascular disease prediction.
Emerging Risk Factors Collaboration, Di Angelantonio E, Gao P, Pennells L, Kaptoge S, Caslake M, Thompson A, Butterworth AS, Sarwar N, Wormser D, Saleheen D, Ballantyne CM, Psaty BM, Sundström J, Ridker PM, Nagel D, Gillum RF, Ford I, Ducimetiere P, Kiechl S, Koenig W, Dullaart RP, Assmann G, D'Agostino RB Sr, Dagenais GR, Cooper JA, Kromhout D, Onat A, Tipping RW, Gómez-de-la-Cámara A, Rosengren A, Sutherland SE, Gallacher J, Fowkes FG, Casiglia E, Hofman A, Salomaa V, Barrett-Connor E, Clarke R, Brunner E, Jukema JW, Simons LA, Sandhu M, Wareham NJ, Khaw KT, Kauhanen J, Salonen JT, Howard WJ, Nordestgaard BG, Wood AM, Thompson SG, Boekholdt SM, Sattar N, Packard C, Gudnason V, Danesh J. Emerging Risk Factors Collaboration, et al. JAMA. 2012 Jun 20;307(23):2499-506. doi: 10.1001/jama.2012.6571. JAMA. 2012. PMID: 22797450 Free PMC article.
RESULTS: The addition of information on various lipid-related markers to total cholesterol, HDL-C, and other conventional risk factors yielded improvement in the model's discrimination: C-index change, 0.0006 (95% CI, 0.0002-0.0009) for the combination of apolipoprotein B …
RESULTS: The addition of information on various lipid-related markers to total cholesterol, HDL-C, and other conventional risk factors yield …
Expression-Based Cell Lineage Analysis in Drosophila Through a Course-Based Research Experience for Early Undergraduates.
Olson JM, Evans CJ, Ngo KT, Kim HJ, Nguyen JD, Gurley KGH, Ta T, Patel V, Han L, Truong-N KT, Liang L, Chu MK, Lam H, Ahn HG, Banerjee AK, Choi IY, Kelley RG, Moridzadeh N, Khan AM, Khan O, Lee S, Johnson EB, Tigranyan A, Wang J, Gandhi AD, Padhiar MM, Calvopina JH, Sumra K, Ou K, Wu JC, Dickan JN, Ahmadi SM, Allen DN, Mai VT, Ansari S, Yeh G, Yoon E, Gon K, Yu JY, He J, Zaretsky JM, Lee NE, Kuoy E, Patananan AN, Sitz D, Tran P, Do MT, Akhave SJ, Alvarez SD, Asem B, Asem N, Azarian NA, Babaesfahani A, Bahrami A, Bhamra M, Bhargava R, Bhatia R, Bhatia S, Bumacod N, Caine JJ, Caldwell TA, Calica NA, Calonico EM, Chan C, Chan HH, Chang A, Chang C, Chang D, Chang JS, Charania N, Chen JY, Chen K, Chen L, Chen Y, Cheung DJ, Cheung JJ, Chew JJ, Chew NB, Chien CT, Chin AM, Chin CJ, Cho Y, Chou MT, Chow KK, Chu C, Chu DM, Chu V, Chuang K, Chugh AS, Cubberly MR, Daniel MG, Datta S, Dhaliwal R, Dinh J, Dixit D, Dowling E, Feng M, From CM, Furukawa D, Gaddipati H, Gevorgyan L, Ghaznavi Z, Ghosh T, Gill J, Groves DJ, Gurara KK, Haghighi AR, Havard AL, Heyrani N, Hioe T, Hong K, Houman JJ, Howland M, Hsia EL, Hsueh J, Hu S, Huang AJ, Huynh JC, Huynh J, Iwuchukwu C, Jang MJ, Jiang AA, Kahlon S, Kao PY, Kaur M, Keehn MG, Kim EJ, Kim H, Kim MJ, Kim SJ, Kitich A, Kornberg RA, Kouzelos NG, Kuon J, Lau B, Lau RK, Law R, Le HD, Le R, Lee C, Lee C, Lee GE, Lee K, Lee MJ, Lee RV, Lee SHK, Lee SK, Lee SD, Lee YJ, Leong MJ, Li DM, Li H, Liang X, Lin E, Lin MM, Lin P, Lin T, Lu S, Luong SS, Ma JS, Ma L, Maghen JN, Mallam S, Mann S, Melehani JH, Miller RC, Mittal N, Moazez CM, Moon S, Moridzadeh R, Ngo K, Nguyen HH, Nguyen K, Nguyen TH, Nieh AW, Niu I, Oh SK, Ong JR, Oyama RK, Park J, Park YA, Passmore KA, Patel A, Patel AA, Patel D, Patel T, Peterson KE, Pham AH, Pham SV, Phuphanich ME, Poria ND, Pourzia A, Ragland V, Ranat RD, Rice CM, Roh D, Rojhani S, Sadri L, Saguros A, Saifee Z, Sandhu M, Scruggs B, Scully LM, Shih V, Shin BA, Sholklapper T, Singh H, Singh S, Snyder SL, Sobotka KF, Song SH, Sukumar S, Sullivan HC, Sy M, Tan H, Taylor SK, Thaker SK, Thakore T, Tong GE, Tran JN, Tran J, Tran TD, Tran V, Trang CL, Trinh HG, Trinh P, Tseng HH, Uotani TT, Uraizee AV, Vu KKT, Vu KKT, Wadhwani K, Walia PK, Wang RS, Wang S, Wang SJ, Wiredja DD, Wong AL, Wu D, Xue X, Yanez G, Yang YH, Ye Z, Yee VW, Yeh C, Zhao Y, Zheng X, Ziegenbalg A, Alkali J, Azizkhanian I, Bhakta A, Berry L, Castillo R, Darwish S, Dickinson H, Dutta R, Ghosh RK, Guerin R, Hofman J, Iwamoto G, Kang S, Kim A, Kim B, Kim H, Kim K, Kim S, Ko J, Koenig M, LaRiviere A, Lee C, Lee J, Lung B, Mittelman M, Murata M, Park Y, Rothberg D, Sprung-Keyser B, Thaker K, Yip V, Picard P, Diep F, Villarasa N, Hartenstein V, Shapiro C, Levis-Fitzgerald M, Jaworski L, Loppato D, Clark IE, Banerjee U. Olson JM, et al. G3 (Bethesda). 2019 Nov 5;9(11):3791-3800. doi: 10.1534/g3.119.400541. G3 (Bethesda). 2019. PMID: 31690598 Free PMC article.
Automatic delineation of functional lung volumes with 68Ga-ventilation/perfusion PET/CT.
Le Roux PY, Siva S, Callahan J, Claudic Y, Bourhis D, Steinfort DP, Hicks RJ, Hofman MS. Le Roux PY, et al. EJNMMI Res. 2017 Oct 10;7(1):82. doi: 10.1186/s13550-017-0332-x. EJNMMI Res. 2017. PMID: 29019109 Free PMC article.
RESULTS: For ventilation volumes, mean volume difference was lowest (- 0.4%) using a 15%max threshold with Pearson's coefficient of 0.71. Applying this cutoff, median DSC was 0.93 (0.87-0.95). ...For perfusion volumes, mean volume difference was lowest and Pearson's
RESULTS: For ventilation volumes, mean volume difference was lowest (- 0.4%) using a 15%max threshold with Pearson's coefficient of 0 …
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