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The delta 6 desaturase knock out mouse reveals that immunomodulatory effects of essential n-6 and n-3 polyunsaturated fatty acids are both independent of and dependent upon conversion.
Monk JM, Liddle DM, Cohen DJ, Tsang DH, Hillyer LM, Abdelmagid SA, Nakamura MT, Power KA, Ma DW, Robinson LE. Monk JM, et al. Among authors: cohen dj. J Nutr Biochem. 2016 Jun;32:29-38. doi: 10.1016/j.jnutbio.2016.01.004. Epub 2016 Mar 2. J Nutr Biochem. 2016. PMID: 27142734 Free article.