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The guidance receptor plexin D1 is a mechanosensor in endothelial cells.

Mehta V, Pang KL, Rozbesky D, Nather K, Keen A, Lachowski D, Kong Y, Karia D, Ameismeier M, Huang J, Fang Y, Del Rio Hernandez A, Reader JS, Jones EY, Tzima E. Mehta V, et al. Among authors: lachowski d. Nature. 2020 Feb;578(7794):290-295. doi: 10.1038/s41586-020-1979-4. Epub 2020 Feb 5. Nature. 2020. PMID: 32025034 Free PMC article.

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FAK controls the mechanical activation of YAP, a transcriptional regulator required for durotaxis.

Lachowski D, Cortes E, Robinson B, Rice A, Rombouts K, Del Río Hernández AE. Lachowski D, et al. FASEB J. 2018 Feb;32(2):1099-1107. doi: 10.1096/fj.201700721R. Epub 2018 Jan 3. FASEB J. 2018. PMID: 29070586

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Syndecan-4 tunes cell mechanics by activating the kindlin-integrin-RhoA pathway.

Chronopoulos A, Thorpe SD, Cortes E, Lachowski D, Rice AJ, Mykuliak VV, Róg T, Lee DA, Hytönen VP, Del Río Hernández AE. Chronopoulos A, et al. Among authors: lachowski d. Nat Mater. 2020 Jun;19(6):669-678. doi: 10.1038/s41563-019-0567-1. Epub 2020 Jan 6. Nat Mater. 2020. PMID: 31907416 Free PMC article.

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Self-Assembling Polypeptide Hydrogels as a Platform to Recapitulate the Tumor Microenvironment.

Lachowski D, Matellan C, Cortes E, Saiani A, Miller AF, Del Río Hernández AE. Lachowski D, et al. Cancers (Basel). 2021 Jun 30;13(13):3286. doi: 10.3390/cancers13133286. Cancers (Basel). 2021. PMID: 34209094 Free PMC article.

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Implementation of a basement membrane invasion assay using mesenteric tissue.

Ghose R, Rice AJ, Cortes E, Ghose U, Lachowski D, Del Rio Hernandez A. Ghose R, et al. Among authors: lachowski d. Methods Cell Biol. 2020;157:99-122. doi: 10.1016/bs.mcb.2019.10.001. Epub 2019 Nov 22. Methods Cell Biol. 2020. PMID: 32334722

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G Protein-Coupled Estrogen Receptor Regulates Actin Cytoskeleton Dynamics to Impair Cell Polarization.

Lachowski D, Cortes E, Matellan C, Rice A, Lee DA, Thorpe SD, Del Río Hernández AE. Lachowski D, et al. Front Cell Dev Biol. 2020 Oct 22;8:592628. doi: 10.3389/fcell.2020.592628. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 33195261 Free PMC article.

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Mechanotransduction in talin through the interaction of the R8 domain with DLC1.

Haining AWM, Rahikainen R, Cortes E, Lachowski D, Rice A, von Essen M, Hytönen VP, Del Río Hernández A. Haining AWM, et al. Among authors: lachowski d. PLoS Biol. 2018 Jul 20;16(7):e2005599. doi: 10.1371/journal.pbio.2005599. eCollection 2018 Jul. PLoS Biol. 2018. PMID: 30028837 Free PMC article.

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GPER Activation Inhibits Cancer Cell Mechanotransduction and Basement Membrane Invasion via RhoA.

Rice A, Cortes E, Lachowski D, Oertle P, Matellan C, Thorpe SD, Ghose R, Wang H, Lee DA, Plodinec M, Del Río Hernández AE. Rice A, et al. Among authors: lachowski d. Cancers (Basel). 2020 Jan 25;12(2):289. doi: 10.3390/cancers12020289. Cancers (Basel). 2020. PMID: 31991740 Free PMC article.

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GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment.

Cortes E, Sarper M, Robinson B, Lachowski D, Chronopoulos A, Thorpe SD, Lee DA, Del Río Hernández AE. Cortes E, et al. Among authors: lachowski d. EMBO Rep. 2019 Jan;20(1):e46556. doi: 10.15252/embr.201846556. Epub 2018 Dec 11. EMBO Rep. 2019. PMID: 30538117 Free PMC article.

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Substrate Stiffness-Driven Membrane Tension Modulates Vesicular Trafficking via Caveolin-1.

Lachowski D, Matellan C, Gopal S, Cortes E, Robinson BK, Saiani A, Miller AF, Stevens MM, Del Río Hernández AE. Lachowski D, et al. ACS Nano. 2022 Mar 22;16(3):4322-4337. doi: 10.1021/acsnano.1c10534. Epub 2022 Mar 7. ACS Nano. 2022. PMID: 35255206 Free PMC article.

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