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72 results

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Page 1
Relevance of Half-Life in Drug Design.
Smith DA, Beaumont K, Maurer TS, Di L. Smith DA, et al. J Med Chem. 2018 May 24;61(10):4273-4282. doi: 10.1021/acs.jmedchem.7b00969. Epub 2017 Nov 17. J Med Chem. 2018. PMID: 29112446
Clearance in Drug Design.
Smith DA, Beaumont K, Maurer TS, Di L. Smith DA, et al. J Med Chem. 2019 Mar 14;62(5):2245-2255. doi: 10.1021/acs.jmedchem.8b01263. Epub 2018 Oct 17. J Med Chem. 2019. PMID: 30281973 Review.
Free Drug Concepts: A Lingering Problem in Drug Discovery.
Webborn PJH, Beaumont K, Martin IJ, Smith DA. Webborn PJH, et al. Among authors: smith da. J Med Chem. 2025 Apr 10;68(7):6850-6856. doi: 10.1021/acs.jmedchem.5c00725. Epub 2025 Mar 21. J Med Chem. 2025. PMID: 40116772 No abstract available.
Why do metabolites circulate?
Smith DA, Dalvie D. Smith DA, et al. Xenobiotica. 2012 Jan;42(1):107-26. doi: 10.3109/00498254.2011.630110. Epub 2011 Nov 24. Xenobiotica. 2012. PMID: 22115420 Review.
Discovery and ADMET: Where are we now.
Smith DA. Smith DA. Curr Top Med Chem. 2011;11(4):467-81. doi: 10.2174/156802611794480909. Curr Top Med Chem. 2011. PMID: 21320070 Review.
Importance of target-mediated drug disposition for small molecules.
Smith DA, van Waterschoot RAB, Parrott NJ, Olivares-Morales A, Lavé T, Rowland M. Smith DA, et al. Drug Discov Today. 2018 Dec;23(12):2023-2030. doi: 10.1016/j.drudis.2018.06.010. Epub 2018 Jun 19. Drug Discov Today. 2018. PMID: 29928850 Review.
Volume of Distribution in Drug Design.
Smith DA, Beaumont K, Maurer TS, Di L. Smith DA, et al. J Med Chem. 2015 Aug 13;58(15):5691-8. doi: 10.1021/acs.jmedchem.5b00201. Epub 2015 Apr 1. J Med Chem. 2015. PMID: 25799158
Do prodrugs deliver?
Smith DA. Smith DA. Curr Opin Drug Discov Devel. 2007 Sep;10(5):550-9. Curr Opin Drug Discov Devel. 2007. PMID: 17786853 Review.
The Critical Role of Passive Permeability in Designing Successful Drugs.
Di L, Artursson P, Avdeef A, Benet LZ, Houston JB, Kansy M, Kerns EH, Lennernäs H, Smith DA, Sugano K. Di L, et al. Among authors: smith da. ChemMedChem. 2020 Oct 19;15(20):1862-1874. doi: 10.1002/cmdc.202000419. Epub 2020 Sep 10. ChemMedChem. 2020. PMID: 32743945 Review.
72 results