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Showing results for dex in gao
Search for Dexin Gao instead (2 results)
ROS-responsive polymer nanoparticles with enhanced loading of dexamethasone effectively modulate the lung injury microenvironment.
Muhammad W, Zhu J, Zhai Z, Xie J, Zhou J, Feng X, Feng B, Pan Q, Li S, Venkatesan R, Li P, Cao H, Gao C. Muhammad W, et al. Acta Biomater. 2022 Aug;148:258-270. doi: 10.1016/j.actbio.2022.06.024. Epub 2022 Jun 18. Acta Biomater. 2022. PMID: 35724918 Free PMC article.
DEX was released faster from the PFTU@DEX NPs in a ROS environment, which could scavenge excessive ROS efficiently both in vitro and in vivo. The PFTU NPs and PFTU@DEX NPs showed no hemolysis and cytotoxicity. Free DEX, PFTU NPs and PFTU@DEX NPs …
DEX was released faster from the PFTU@DEX NPs in a ROS environment, which could scavenge excessive ROS efficiently both in vit …
Universal immunotherapeutic strategy for hepatocellular carcinoma with exosome vaccines that engage adaptive and innate immune responses.
Zuo B, Zhang Y, Zhao K, Wu L, Qi H, Yang R, Gao X, Geng M, Wu Y, Jing R, Zhou Q, Seow Y, Yin H. Zuo B, et al. J Hematol Oncol. 2022 Apr 29;15(1):46. doi: 10.1186/s13045-022-01266-8. J Hematol Oncol. 2022. PMID: 35488312 Free PMC article.
METHODS: Here, we demonstrate a general strategy for biological nanovaccines that trigger tailored tumor-specific immune responses for hepatocellular carcinoma (HCC). Dendritic cell (DC)-derived exosomes (DEX) are painted with a HCC-targeting peptide (P47-P), an alpha-feto …
METHODS: Here, we demonstrate a general strategy for biological nanovaccines that trigger tailored tumor-specific immune responses for hepat …
Dendritic cell-derived exosomes elicit tumor regression in autochthonous hepatocellular carcinoma mouse models.
Lu Z, Zuo B, Jing R, Gao X, Rao Q, Liu Z, Qi H, Guo H, Yin H. Lu Z, et al. J Hepatol. 2017 Oct;67(4):739-748. doi: 10.1016/j.jhep.2017.05.019. Epub 2017 May 24. J Hepatol. 2017. PMID: 28549917
METHODS: Exosomes derived from alpha-fetoprotein (AFP)-expressing DCs (DEX(AFP)) were investigated in three different HCC mouse models systemically. ...Lack of efficacy in athymic nude mice and CD8(+) T cell-depleted mice showed that T cells contribute to DEX(AFP)-m …
METHODS: Exosomes derived from alpha-fetoprotein (AFP)-expressing DCs (DEX(AFP)) were investigated in three different HCC mouse model …
Dexmedetomidine inhibits inflammation in microglia cells under stimulation of LPS and ATP by c-Fos/NLRP3/caspase-1 cascades.
Li H, Zhang X, Chen M, Chen J, Gao T, Yao S. Li H, et al. EXCLI J. 2018 Mar 22;17:302-311. doi: 10.17179/excli2017-1018. eCollection 2018. EXCLI J. 2018. PMID: 29743866 Free PMC article.
The present study was aimed to investigate effect of Dex on NLRP3 activity in activated microglia and reveal the underlying mechanisms. ...The present study revealed that Dex inhibits inflammation in microglia cells under stimulation of LPS and ATP by c-Fos/NLRP3/ca …
The present study was aimed to investigate effect of Dex on NLRP3 activity in activated microglia and reveal the underlying mechanism …
In vivo and in vitro protective effects of shengmai injection against doxorubicin-induced cardiotoxicity.
Zhou P, Gao G, Zhao CC, Li JY, Peng JF, Wang SS, Song R, Shi H, Wang L. Zhou P, et al. Pharm Biol. 2022 Dec;60(1):638-651. doi: 10.1080/13880209.2022.2046801. Pharm Biol. 2022. PMID: 35298357 Free PMC article.
MATERIALS AND METHODS: In vivo, DOX (15 mg/kg) was intraperitoneally injected in model, Dex (dexrazoxane), SMI-L (2.7 mL/kg), SMI-M (5.4 mL/kg), and SMI-H (10.8 mL/kg) for 7 consecutive days. ...Compared with the model group, the protein expression of nuclear factor erythr …
MATERIALS AND METHODS: In vivo, DOX (15 mg/kg) was intraperitoneally injected in model, Dex (dexrazoxane), SMI-L (2.7 mL/kg), SMI-M ( …
Reactive oxygen species (ROS)-responsive nanoprobe for bioimaging and targeting therapy of osteoarthritis.
Shen C, Gao M, Chen H, Zhan Y, Lan Q, Li Z, Xiong W, Qin Z, Zheng L, Zhao J. Shen C, et al. J Nanobiotechnology. 2021 Nov 27;19(1):395. doi: 10.1186/s12951-021-01136-4. J Nanobiotechnology. 2021. PMID: 34838028 Free PMC article.
This nanoprobe was fabricated by using PEG micelles modified with ROS-sensitive thioketal linkers (TK) and cartilage-targeting peptide, termed TKCP, which was then encapsulated with Dexamethasone (DEX) to form TKCP@DEX nanoparticles. Results showed that the nanoprob …
This nanoprobe was fabricated by using PEG micelles modified with ROS-sensitive thioketal linkers (TK) and cartilage-targeting peptide, term …
Dexamethasone-loaded ROS-responsive poly(thioketal) nanoparticles suppress inflammation and oxidative stress of acute lung injury.
Zhai Z, Ouyang W, Yao Y, Zhang Y, Zhang H, Xu F, Gao C. Zhai Z, et al. Bioact Mater. 2022 Feb 11;14:430-442. doi: 10.1016/j.bioactmat.2022.01.047. eCollection 2022 Aug. Bioact Mater. 2022. PMID: 35415281 Free PMC article.
Herein, a therapeutic nanoplatform with reactive oxygen species (ROS)-responsiveness was developed for the regulation of inflammation. Dexamethasone acetate (Dex) was encapsulated into poly(thioketal) polymers to form polymeric nanoparticles (NPs) (PTKNPs@Dex). The …
Herein, a therapeutic nanoplatform with reactive oxygen species (ROS)-responsiveness was developed for the regulation of inflammation. Dexam …
Dendritic cell‑derived exosomal miR‑494‑3p promotes angiogenesis following myocardial infarction.
Liu H, Zhang Y, Yuan J, Gao W, Zhong X, Yao K, Lin L, Ge J. Liu H, et al. Int J Mol Med. 2021 Jan;47(1):315-325. doi: 10.3892/ijmm.2020.4776. Epub 2020 Nov 2. Int J Mol Med. 2021. PMID: 33416108 Free PMC article.
It was observed that, compared with the control group, DEXs from the MI group significantly upregulated the expression of VEGF in CMECs, enhanced tube formation by CMECs, and upregulated the expression of VEGF and CD31 in the infarcted myocardium of MI model mice. miR-494-3p and …
It was observed that, compared with the control group, DEXs from the MI group significantly upregulated the expression of VEGF in CMECs, enh …
PINK1-mediated mitophagy contributes to glucocorticoid-induced cathepsin K production in osteocytes.
Yuan J, Gao YS, Liu DL, Pang Tai AC, Zhou H, Papadimitriou JM, Zhang CQ, Zheng MH, Gao JJ. Yuan J, et al. J Orthop Translat. 2022 Nov 24;38:229-240. doi: 10.1016/j.jot.2022.11.003. eCollection 2023 Jan. J Orthop Translat. 2022. PMID: 36474855 Free PMC article.
METHODS: Gene expression of Ctsk and protein levels of cathepsin K were assessed in MLO-Y4 cell lines exposed to dexamethasone (Dex) of different time (0, 12, 24 hours) and dose (0, 10-8 and 10-6 M) courses by RT-qPCR and western blotting, respectively. ...MitoTracker Red …
METHODS: Gene expression of Ctsk and protein levels of cathepsin K were assessed in MLO-Y4 cell lines exposed to dexamethasone (Dex) …
236 results