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Year Number of Results
2005 2
2006 1
2008 5
2009 1
2010 3
2011 1
2012 2
2013 5
2014 3
2015 2
2016 1
2017 6
2018 5
2019 7
2020 5
2021 19
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2026 4

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118 results

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Page 1
A coronavirus assembly inhibitor that targets the viral membrane protein.
Laporte M, Jochmans D, Bardiot D, Desmarets L, Debski-Antoniak OJ, Mizzon G, Abdelnabi R, Leyssen P, Chiu W, Zhang Z, Nomura N, Boland S, Ohto U, Stahl Y, Wuyts J, De Jonghe S, Stevaert A, van Hemert MJ, Bontes BW, Wanningen P, Groenewold GJM, Zegar A, Owczarek K, Joshi S, Koukni M, Arzel P, Klaassen H, Vanherck JC, Vandecaetsbeek I, Cremers N, Donckers K, Francken T, Van Buyten T, Rymenants J, Schepers J, Pyrc K, Hilgenfeld R, Dubuisson J, Bosch BJ, Van Kuppeveld F, Eydoux C, Decroly E, Canard B, Naesens L, Weynand B, Snijder EJ, Belouzard S, Shimizu T, Bartenschlager R, Hurdiss DL, Marchand A, Chaltin P, Neyts J. Laporte M, et al. Among authors: jochmans d. Nature. 2025 Apr;640(8058):514-523. doi: 10.1038/s41586-025-08773-x. Epub 2025 Mar 26. Nature. 2025. PMID: 40140569 Free PMC article.
Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors.
Boby ML, Fearon D, Ferla M, Filep M, Koekemoer L, Robinson MC; COVID Moonshot Consortium‡; Chodera JD, Lee AA, London N, von Delft A, von Delft F, Achdout H, Aimon A, Alonzi DS, Arbon R, Aschenbrenner JC, Balcomb BH, Bar-David E, Barr H, Ben-Shmuel A, Bennett J, Bilenko VA, Borden B, Boulet P, Bowman GR, Brewitz L, Brun J, Bvnbs S, Calmiano M, Carbery A, Carney DW, Cattermole E, Chang E, Chernyshenko E, Clyde A, Coffland JE, Cohen G, Cole JC, Contini A, Cox L, Croll TI, Cvitkovic M, De Jonghe S, Dias A, Donckers K, Dotson DL, Douangamath A, Duberstein S, Dudgeon T, Dunnett LE, Eastman P, Erez N, Eyermann CJ, Fairhead M, Fate G, Fedorov O, Fernandes RS, Ferrins L, Foster R, Foster H, Fraisse L, Gabizon R, García-Sastre A, Gawriljuk VO, Gehrtz P, Gileadi C, Giroud C, Glass WG, Glen RC, Glinert I, Godoy AS, Gorichko M, Gorrie-Stone T, Griffen EJ, Haneef A, Hassell Hart S, Heer J, Henry M, Hill M, Horrell S, Huang QYJ, Huliak VD, Hurley MFD, Israely T, Jajack A, Jansen J, Jnoff E, Jochmans D, John T, Kaminow B, Kang L, Kantsadi AL, Kenny PW, Kiappes JL, Kinakh SO, Kovar B, Krojer T, La VNT, Laghnimi-Hahn S, Lefker BA, Levy H, Lithgo RM, Logvinenko IG, Lukacik P, Macdonald HB, M… See abstract for full author list ➔ Boby ML, et al. Among authors: jochmans d. Science. 2023 Nov 10;382(6671):eabo7201. doi: 10.1126/science.abo7201. Epub 2023 Nov 10. Science. 2023. PMID: 37943932 Free PMC article.
A small-molecule SARS-CoV-2 inhibitor targeting the membrane protein.
Van Damme E, Abeywickrema P, Yin Y, Xie J, Jacobs S, Mann MK, Doijen J, Miller R, Piassek M, Marsili S, Subramanian M, Gottlieb L, Abdelnabi R, Van Gool M, Van den Broeck N, De Pauw I, Diels A, Vermeulen P, Temmerman K, Scobey T, Mattocks M, Schäfer A, Jochmans D, De Jonghe S, Leyssen P, Chiu W, Diosa Toro M, Zwaagstra M, Leijs AA, De Gruyter HLM, Buyck C, Van Den Heede K, Jacobs F, Van den Eynde C, Thijs L, Raeymaekers V, Miller S, Del Rosario A, Neyts J, Peeters D, Baric RS, van Kuppeveld FJM, Snijder EJ, van Hemert MJ, Monshouwer M, Sharma S, Draghia-Akli R, Koul A, Van Loock M. Van Damme E, et al. Among authors: jochmans d. Nature. 2025 Apr;640(8058):506-513. doi: 10.1038/s41586-025-08651-6. Epub 2025 Mar 26. Nature. 2025. PMID: 40140563 Free PMC article.
Discovery and Preclinical Profile of ALG-097558, a Pan-Coronavirus 3CLpro Inhibitor.
Bardiot D, McGowan DC, Gupta K, Deval J, Chang S, Jekle A, Liu C, Stevens S, Serebryany V, Tauchert MJ, Maskos K, Stoycheva AD, Ren S, Jaisinghani R, Faucher MO, Lin TI, Boland S, Chaltin P, Marchand A, Wuyts J, De Jonghe S, Jochmans D, Anugu S, Baloju V, Deta K, Welch M, Leyssen P, Neyts J, Laporte M, Abdelnabi R, Hu H, Zhang P, Le K, Chanda S, Smith DB, Raboisson P, Beigelman L, Symons JA, Blatt L, Vandyck K. Bardiot D, et al. Among authors: jochmans d. J Med Chem. 2025 Jul 10;68(13):13436-13454. doi: 10.1021/acs.jmedchem.5c00088. Epub 2025 Jun 30. J Med Chem. 2025. PMID: 40586480
Discovery of orally bioavailable Zika and West Nile Virus antiviral compounds targeting the NS2B-NS3 protease.
Kenton NT, Barr H, Cherepakha A, Coelmont L, Collard C, Cousins D, Davies GHM, Degtyarenko O, Dirksen A, Elbrecht D, Fearon D, Gayvert J, Griffen E, Jochmans D, Kaptein S, Kliatskiy P, Kochetkov A, Kordubailo M, Lahav N, London N, Maas E, Marples P, Nady N, Neyts J, Nguyen L, Ni X, Ogorodnik Y, Robinson MC, Simpson CT, Tarabara I, Tkachenko A, von Delft A, von Delft F, Yakymenko O, Lee AA. Kenton NT, et al. Among authors: jochmans d. bioRxiv [Preprint]. 2025 Jun 20:2025.06.19.660642. doi: 10.1101/2025.06.19.660642. bioRxiv. 2025. PMID: 40667021 Free PMC article. Preprint.
Human Myelin Spheres for in Vitro Oligodendrocyte Maturation, Myelination and Neurological Disease Modeling.
Ahuja K, Ramezankhani R, Wang X, Burg T, Amos G, Neyrinck K, Silva A, Arekatla G, Cassidy EE, Nami F, Terryn J, Wierda K, Vints K, Vandamme N, Poovathingal S, Lambrichts I, Swinnen JV, Van Den Bosch L, De Groef L, Moons L, Verfaillie C, Neyts J, Jochmans D, Chai YC. Ahuja K, et al. Among authors: jochmans d. Stem Cell Rev Rep. 2026 Apr;22(3):1420-1441. doi: 10.1007/s12015-026-11061-4. Epub 2026 Jan 28. Stem Cell Rev Rep. 2026. PMID: 41593300 Free PMC article.
118 results