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Structural Basis for the RNA-Guided Ribonuclease Activity of CRISPR-Cas13d.

Zhang C, Konermann S, Brideau NJ, Lotfy P, Wu X, Novick SJ, Strutzenberg T, Griffin PR, Hsu PD, Lyumkis D. Zhang C, et al. Among authors: lyumkis d. Cell. 2018 Sep 20;175(1):212-223.e17. doi: 10.1016/j.cell.2018.09.001. Cell. 2018. PMID: 30241607 Free PMC article.

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Retroviral integrase: Structure, mechanism, and inhibition.

Passos DO, Li M, Craigie R, Lyumkis D. Passos DO, et al. Among authors: lyumkis d. Enzymes. 2021;50:249-300. doi: 10.1016/bs.enz.2021.06.007. Epub 2021 Aug 23. Enzymes. 2021. PMID: 34861940 Free PMC article.

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Integrase Strand Transfer Inhibitors Are Effective Anti-HIV Drugs.

Smith SJ, Zhao XZ, Passos DO, Lyumkis D, Burke TR Jr, Hughes SH. Smith SJ, et al. Among authors: lyumkis d. Viruses. 2021 Jan 29;13(2):205. doi: 10.3390/v13020205. Viruses. 2021. PMID: 33572956 Free PMC article. Review.

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Challenges and opportunities in cryo-EM single-particle analysis.

Lyumkis D. Lyumkis D. J Biol Chem. 2019 Mar 29;294(13):5181-5197. doi: 10.1074/jbc.REV118.005602. Epub 2019 Feb 25. J Biol Chem. 2019. PMID: 30804214 Free PMC article. Review.

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Evaluating Local and Directional Resolution of Cryo-EM Density Maps.

Aiyer S, Zhang C, Baldwin PR, Lyumkis D. Aiyer S, et al. Among authors: lyumkis d. Methods Mol Biol. 2021;2215:161-187. doi: 10.1007/978-1-0716-0966-8_8. Methods Mol Biol. 2021. PMID: 33368004 Free PMC article.

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Structural Biology of HIV Integrase Strand Transfer Inhibitors.

Jóźwik IK, Passos DO, Lyumkis D. Jóźwik IK, et al. Among authors: lyumkis d. Trends Pharmacol Sci. 2020 Sep;41(9):611-626. doi: 10.1016/j.tips.2020.06.003. Epub 2020 Jul 3. Trends Pharmacol Sci. 2020. PMID: 32624197 Free PMC article. Review.

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SrmB Rescues Trapped Ribosome Assembly Intermediates.

Rabuck-Gibbons JN, Popova AM, Greene EM, Cervantes CF, Lyumkis D, Williamson JR. Rabuck-Gibbons JN, et al. Among authors: lyumkis d. J Mol Biol. 2020 Feb 14;432(4):978-990. doi: 10.1016/j.jmb.2019.12.013. Epub 2019 Dec 23. J Mol Biol. 2020. PMID: 31877323 Free PMC article.

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Tools for visualizing and analyzing Fourier space sampling in Cryo-EM.

Baldwin PR, Lyumkis D. Baldwin PR, et al. Among authors: lyumkis d. Prog Biophys Mol Biol. 2021 Mar;160:53-65. doi: 10.1016/j.pbiomolbio.2020.06.003. Epub 2020 Jul 6. Prog Biophys Mol Biol. 2021. PMID: 32645314 Free PMC article. Review.

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Structural basis for strand-transfer inhibitor binding to HIV intasomes.

Passos DO, Li M, Jóźwik IK, Zhao XZ, Santos-Martins D, Yang R, Smith SJ, Jeon Y, Forli S, Hughes SH, Burke TR Jr, Craigie R, Lyumkis D. Passos DO, et al. Among authors: lyumkis d. Science. 2020 Feb 14;367(6479):810-814. doi: 10.1126/science.aay8015. Epub 2020 Jan 30. Science. 2020. PMID: 32001521 Free PMC article.

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Non-uniformity of projection distributions attenuates resolution in Cryo-EM.

Baldwin PR, Lyumkis D. Baldwin PR, et al. Among authors: lyumkis d. Prog Biophys Mol Biol. 2020 Jan;150:160-183. doi: 10.1016/j.pbiomolbio.2019.09.002. Epub 2019 Sep 13. Prog Biophys Mol Biol. 2020. PMID: 31525386 Free PMC article.

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