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Page 1
The Paradox of Coenzyme Q10 in Aging.
Díaz-Casado ME, Quiles JL, Barriocanal-Casado E, González-García P, Battino M, López LC, Varela-López A. Díaz-Casado ME, et al. Among authors: barriocanal casado e. Nutrients. 2019 Sep 14;11(9):2221. doi: 10.3390/nu11092221. Nutrients. 2019. PMID: 31540029 Free PMC article. Review.
Metabolic Targets of Coenzyme Q10 in Mitochondria.
Hidalgo-Gutiérrez A, González-García P, Díaz-Casado ME, Barriocanal-Casado E, López-Herrador S, Quinzii CM, López LC. Hidalgo-Gutiérrez A, et al. Among authors: barriocanal casado e. Antioxidants (Basel). 2021 Mar 26;10(4):520. doi: 10.3390/antiox10040520. Antioxidants (Basel). 2021. PMID: 33810539 Free PMC article. Review.
Animal Models of Coenzyme Q Deficiency: Mechanistic and Translational Learnings.
González-García P, Barriocanal-Casado E, Díaz-Casado ME, López-Herrador S, Hidalgo-Gutiérrez A, López LC. González-García P, et al. Among authors: barriocanal casado e. Antioxidants (Basel). 2021 Oct 26;10(11):1687. doi: 10.3390/antiox10111687. Antioxidants (Basel). 2021. PMID: 34829558 Free PMC article. Review.
β-RA Targets Mitochondrial Metabolism and Adipogenesis, Leading to Therapeutic Benefits against CoQ Deficiency and Age-Related Overweight.
Hidalgo-Gutiérrez A, Barriocanal-Casado E, Díaz-Casado ME, González-García P, Zenezini Chiozzi R, Acuña-Castroviejo D, López LC. Hidalgo-Gutiérrez A, et al. Among authors: barriocanal casado e. Biomedicines. 2021 Oct 13;9(10):1457. doi: 10.3390/biomedicines9101457. Biomedicines. 2021. PMID: 34680574 Free PMC article.
β-RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9 R239X mice.
Hidalgo-Gutiérrez A, Barriocanal-Casado E, Bakkali M, Díaz-Casado ME, Sánchez-Maldonado L, Romero M, Sayed RK, Prehn C, Escames G, Duarte J, Acuña-Castroviejo D, López LC. Hidalgo-Gutiérrez A, et al. Among authors: barriocanal casado e. EMBO Mol Med. 2019 Jan;11(1):e9466. doi: 10.15252/emmm.201809466. EMBO Mol Med. 2019. PMID: 30482867 Free PMC article.
Coenzyme Q10 modulates sulfide metabolism and links the mitochondrial respiratory chain to pathways associated to one carbon metabolism.
González-García P, Hidalgo-Gutiérrez A, Mascaraque C, Barriocanal-Casado E, Bakkali M, Ziosi M, Abdihankyzy UB, Sánchez-Hernández S, Escames G, Prokisch H, Martín F, Quinzii CM, López LC. González-García P, et al. Among authors: barriocanal casado e. Hum Mol Genet. 2020 Nov 25;29(19):3296-3311. doi: 10.1093/hmg/ddaa214. Hum Mol Genet. 2020. PMID: 32975579 Free PMC article.
Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis.
Rodríguez-Hidalgo M, Luna-Sánchez M, Hidalgo-Gutiérrez A, Barriocanal-Casado E, Mascaraque C, Acuña-Castroviejo D, Rivera M, Escames G, López LC. Rodríguez-Hidalgo M, et al. Among authors: barriocanal casado e. Sci Rep. 2018 Sep 18;8(1):14013. doi: 10.1038/s41598-018-32190-y. Sci Rep. 2018. PMID: 30228311 Free PMC article.
The Q-junction and the inflammatory response are critical pathological and therapeutic factors in CoQ deficiency.
González-García P, Díaz-Casado ME, Hidalgo-Gutiérrez A, Jiménez-Sánchez L, Bakkali M, Barriocanal-Casado E, Escames G, Chiozzi RZ, Völlmy F, Zaal EA, Berkers CR, Heck AJR, López LC. González-García P, et al. Among authors: barriocanal casado e. Redox Biol. 2022 Jul 15;55:102403. doi: 10.1016/j.redox.2022.102403. Online ahead of print. Redox Biol. 2022. PMID: 35863266 Free PMC article.
CoQ deficiency causes disruption of mitochondrial sulfide oxidation, a new pathomechanism associated with this syndrome.
Luna-Sánchez M, Hidalgo-Gutiérrez A, Hildebrandt TM, Chaves-Serrano J, Barriocanal-Casado E, Santos-Fandila Á, Romero M, Sayed RK, Duarte J, Prokisch H, Schuelke M, Distelmaier F, Escames G, Acuña-Castroviejo D, López LC. Luna-Sánchez M, et al. Among authors: barriocanal casado e. EMBO Mol Med. 2017 Jan;9(1):78-95. doi: 10.15252/emmm.201606345. EMBO Mol Med. 2017. PMID: 27856619 Free PMC article.
13 results