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Intratumoral delivery of lipid nanoparticle-formulated mRNA encoding IL-21, IL-7, and 4-1BBL induces systemic anti-tumor immunity.
Hamouda AEI, Filtjens J, Brabants E, Kancheva D, Debraekeleer A, Brughmans J, Jacobs L, Bardet PMR, Knetemann E, Lefesvre P, Allonsius L, Gontsarik M, Varela I, Crabbé M, Clappaert EJ, Cappellesso F, Caro AA, Gordún Peiró A, Fredericq L, Hadadi E, Estapé Senti M, Schiffelers R, van Grunsven LA, Aboubakar Nana F, De Geest BG, Deschoemaeker S, De Koker S, Lambolez F, Laoui D. Hamouda AEI, et al. Among authors: knetemann e. Nat Commun. 2024 Dec 6;15(1):10635. doi: 10.1038/s41467-024-54877-9. Nat Commun. 2024. PMID: 39639025 Free PMC article.