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CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson's disease.
Bengoa-Vergniory N, Faggiani E, Ramos-Gonzalez P, Kirkiz E, Connor-Robson N, Brown LV, Siddique I, Li Z, Vingill S, Cioroch M, Cavaliere F, Threlfell S, Roberts B, Schrader T, Klärner FG, Cragg S, Dehay B, Bitan G, Matute C, Bezard E, Wade-Martins R. Bengoa-Vergniory N, et al. Among authors: faggiani e. Nat Commun. 2020 Sep 28;11(1):4885. doi: 10.1038/s41467-020-18689-x. Nat Commun. 2020. PMID: 32985503 Free PMC article.
Novel self-replicating α-synuclein polymorphs that escape ThT monitoring can spontaneously emerge and acutely spread in neurons.
De Giorgi F, Laferrière F, Zinghirino F, Faggiani E, Lends A, Bertoni M, Yu X, Grélard A, Morvan E, Habenstein B, Dutheil N, Doudnikoff E, Daniel J, Claverol S, Qin C, Loquet A, Bezard E, Ichas F. De Giorgi F, et al. Among authors: faggiani e. Sci Adv. 2020 Oct 2;6(40):eabc4364. doi: 10.1126/sciadv.abc4364. Print 2020 Oct. Sci Adv. 2020. PMID: 33008896 Free PMC article.