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2018 1
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2020 3
2021 2
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Page 1
Discovery, Function, and Therapeutic Targeting of Siglec-8.
Youngblood BA, Leung J, Falahati R, Williams J, Schanin J, Brock EC, Singh B, Chang AT, O'Sullivan JA, Schleimer RP, Tomasevic N, Bebbington CR, Bochner BS. Youngblood BA, et al. Among authors: brock ec. Cells. 2020 Dec 24;10(1):19. doi: 10.3390/cells10010019. Cells. 2020. PMID: 33374255 Free PMC article. Review.
AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice.
Youngblood BA, Brock EC, Leung J, Falahati R, Bryce PJ, Bright J, Williams J, Shultz LD, Greiner DL, Brehm MA, Bebbington C, Tomasevic N. Youngblood BA, et al. Among authors: brock ec. Int Arch Allergy Immunol. 2019;180(2):91-102. doi: 10.1159/000501637. Epub 2019 Aug 9. Int Arch Allergy Immunol. 2019. PMID: 31401630 Free PMC article.
A monoclonal antibody to Siglec-8 suppresses non-allergic airway inflammation and inhibits IgE-independent mast cell activation.
Schanin J, Gebremeskel S, Korver W, Falahati R, Butuci M, Haw TJ, Nair PM, Liu G, Hansbro NG, Hansbro PM, Evensen E, Brock EC, Xu A, Wong A, Leung J, Bebbington C, Tomasevic N, Youngblood BA. Schanin J, et al. Among authors: brock ec. Mucosal Immunol. 2021 Mar;14(2):366-376. doi: 10.1038/s41385-020-00336-9. Epub 2020 Aug 19. Mucosal Immunol. 2021. PMID: 32814824 Free PMC article.
Sialic acid-binding immunoglobulin-like lectin (Siglec) 8 in patients with eosinophilic disorders: Receptor expression and targeting using chimeric antibodies.
Legrand F, Cao Y, Wechsler JB, Zhu X, Zimmermann N, Rampertaap S, Monsale J, Romito K, Youngblood BA, Brock EC, Makiya MA, Tomasevic N, Bebbington C, Maric I, Metcalfe DD, Bochner BS, Klion AD. Legrand F, et al. Among authors: brock ec. J Allergy Clin Immunol. 2019 Jun;143(6):2227-2237.e10. doi: 10.1016/j.jaci.2018.10.066. Epub 2018 Dec 10. J Allergy Clin Immunol. 2019. PMID: 30543818 Free PMC article.
Mast Cell and Eosinophil Activation Are Associated With COVID-19 and TLR-Mediated Viral Inflammation: Implications for an Anti-Siglec-8 Antibody.
Gebremeskel S, Schanin J, Coyle KM, Butuci M, Luu T, Brock EC, Xu A, Wong A, Leung J, Korver W, Morin RD, Schleimer RP, Bochner BS, Youngblood BA. Gebremeskel S, et al. Among authors: brock ec. Front Immunol. 2021 Mar 10;12:650331. doi: 10.3389/fimmu.2021.650331. eCollection 2021. Front Immunol. 2021. PMID: 33777047 Free PMC article.