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NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo.
Namoto K, Baader C, Orsini V, Landshammer A, Breuer E, Dinh KT, Ungricht R, Pikiolek M, Laurent S, Lu B, Aebi A, Schönberger K, Vangrevelinghe E, Evrova O, Sun T, Annunziato S, Lachal J, Redmond E, Wang L, Wetzel K, Capodieci P, Turner J, Schutzius G, Unterreiner V, Trunzer M, Buschmann N, Behnke D, Machauer R, Scheufler C, Parker CN, Ferro M, Grevot A, Beyerbach A, Lu WY, Forbes SJ, Wagner J, Bouwmeester T, Liu J, Sohal B, Sahambi S, Greenbaum LE, Lohmann F, Hoppe P, Cong F, Sailer AW, Ruffner H, Glatthar R, Humar B, Clavien PA, Dill MT, George E, Maibaum J, Liberali P, Tchorz JS. Namoto K, et al. Among authors: redmond e. Cell Stem Cell. 2024 Apr 4;31(4):554-569.e17. doi: 10.1016/j.stem.2024.03.003. Cell Stem Cell. 2024. PMID: 38579685 Free article.
The Hsd17b13P260S patient variant knock-in male mouse model provides translational insights into HSD17B13 biology.
Slabber CF, Lenkeit F, Grove K, Aebi A, Orsini V, Reyes A, Ludwig V, Crochemore C, Bergling S, Wild S, Naumann U, Enos K, Abrams AS, Zeller H, Bhol R, Wang L, Redmond E, Wetzel K, Capodieci P, Heikelä H, Martinez-Nieto G, Mairinoja L, Sipilä P, Strauss L, Baumgarten BU, George EL, Heim M, Terracciano L, Bouwmeester A, Tchorz JS, Poutanen M, Ruffner H, Bordoli MR. Slabber CF, et al. Among authors: redmond e. EBioMedicine. 2026 Sep;131:106429. doi: 10.1016/j.ebiom.2026.106429. Epub 2026 Aug 14. EBioMedicine. 2026. PMID: 42600259 Free PMC article.
What about the Rest of Them? Fatal Injuries Related to Production Agriculture Not Captured by the Bureau of Labor Statistics (BLS) Census of Fatal Occupational Injuries (CFOI).
Weichelt B, Scott E, Burke R, Shutske J, Gorucu S, Sanderson W, Madsen M, Redmond E, Murphy DJ, Rautiainen R. Weichelt B, et al. Among authors: redmond e. J Agromedicine. 2022 Jan;27(1):35-40. doi: 10.1080/1059924X.2021.1956663. Epub 2021 Jul 29. J Agromedicine. 2022. PMID: 34278984 Free article.
Discovery and Optimization of Selective Inhibitors of Large Tumor Suppressor Kinases LATS1 and 2 for In Vivo Investigation of the Hippo-YAP Pathway in Tissue Regeneration.
Namoto K, Vangrevelinghe E, Machauer R, Behnke D, Buschmann N, Lachal J, Schipp K, Sorge M, Barker K, Fabbiani F, Piechon P, Connor LE, Laurent S, Lohmann F, Unterreiner V, George EL, Redmond E, Wang L, Scheufler C, Sohal B, Sailer AW, Glatthar R, Tchorz JS, Maibaum J. Namoto K, et al. Among authors: redmond e. J Med Chem. 2025 Jul 10;68(13):13591-13608. doi: 10.1021/acs.jmedchem.5c00350. Epub 2025 Jun 26. J Med Chem. 2025. PMID: 40574495