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The following term was not found in PubMed: Gulher
Page 1
Did you mean emre gulder (1 results)?
The mitochondrial calcium uniporter engages UCP1 to form a thermoporter that promotes thermogenesis.
Xue K, Wu D, Wang Y, Zhao Y, Shen H, Yao J, Huang X, Li X, Zhou Z, Wang Z, Qiu Y. Xue K, et al. Cell Metab. 2022 Sep 6;34(9):1325-1341.e6. doi: 10.1016/j.cmet.2022.07.011. Epub 2022 Aug 16. Cell Metab. 2022. PMID: 35977541 Free article.
Here, we show that mitochondrial calcium uniporter (MCU) recruits UCP1 through essential MCU regulator (EMRE) to form an MCU-EMRE-UCP1 complex upon adrenergic stimulation. This complex formation increases mitochondrial calcium uptake to accelerate the tricarboxylic …
Here, we show that mitochondrial calcium uniporter (MCU) recruits UCP1 through essential MCU regulator (EMRE) to form an MCU-EMRE …
Berberine is a Novel Mitochondrial Calcium Uniporter Inhibitor that Disrupts MCU-EMRE Assembly.
Zhao H, Chen S, Cao N, Wu W, Liu G, Gao J, Chen J, Li T, Lu D, Zeng L, Zhu H, Zhang W, Xia Q, Li T, Zhou T, Zhang XM, Li AL, Pan X. Zhao H, et al. Adv Sci (Weinh). 2025 May;12(17):e2412311. doi: 10.1002/advs.202412311. Epub 2025 Feb 7. Adv Sci (Weinh). 2025. PMID: 39921279 Free PMC article.
This binding disrupts the interaction of MCU with its essential regulator, EMRE, thereby inhibiting rapid Ca(2+) entry into the mitochondria. Notably, Berberine pretreatment reduces mitochondrial Ca(2+) overload and mitigates ischemia/reperfusion-induced myocardial injury …
This binding disrupts the interaction of MCU with its essential regulator, EMRE, thereby inhibiting rapid Ca(2+) entry into the mitoc …
New free-exchange model of EmrE transport.
Robinson AE, Thomas NE, Morrison EA, Balthazor BM, Henzler-Wildman KA. Robinson AE, et al. Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):E10083-E10091. doi: 10.1073/pnas.1708671114. Epub 2017 Nov 7. Proc Natl Acad Sci U S A. 2017. PMID: 29114048 Free PMC article.
Here we show that EmrE breaks the rules generally deemed essential for coupled antiport. NMR spectra reveal that EmrE can simultaneously bind and cotransport proton and drug. ...We present a free-exchange model for EmrE antiport that is consistent with these …
Here we show that EmrE breaks the rules generally deemed essential for coupled antiport. NMR spectra reveal that EmrE can simu …
EMRE is essential for mitochondrial calcium uniporter activity in a mouse model.
Liu JC, Syder NC, Ghorashi NS, Willingham TB, Parks RJ, Sun J, Fergusson MM, Liu J, Holmström KM, Menazza S, Springer DA, Liu C, Glancy B, Finkel T, Murphy E. Liu JC, et al. JCI Insight. 2020 Feb 27;5(4):e134063. doi: 10.1172/jci.insight.134063. JCI Insight. 2020. PMID: 32017711 Free PMC article.
Here we characterize a mouse model of EMRE deletion and show that EMRE is indeed required for mitochondrial calcium uniporter function in vivo. ...Finally, to investigate the role of EMRE in disease processes, we examine the effects of EMRE deletion in …
Here we characterize a mouse model of EMRE deletion and show that EMRE is indeed required for mitochondrial calcium uniporter …
Asymmetric protonation of EmrE.
Morrison EA, Robinson AE, Liu Y, Henzler-Wildman KA. Morrison EA, et al. J Gen Physiol. 2015 Dec;146(6):445-61. doi: 10.1085/jgp.201511404. Epub 2015 Nov 16. J Gen Physiol. 2015. PMID: 26573622 Free PMC article.
The small multidrug resistance transporter EmrE is a homodimer that uses energy provided by the proton motive force to drive the efflux of drug substrates. ...However, the results raise new questions regarding the coupling mechanism because they show that EmrE exist …
The small multidrug resistance transporter EmrE is a homodimer that uses energy provided by the proton motive force to drive the effl …
Preface.
Emre SH, Eldegez U. Emre SH, et al. Transplant Proc. 2017 Apr;49(3):391. doi: 10.1016/j.transproceed.2017.02.012. Transplant Proc. 2017. PMID: 28340796 No abstract available.
Microsecond Motion of the Bacterial Transporter EmrE in Lipid Bilayers.
Shcherbakov AA, Brousseau M, Henzler-Wildman KA, Hong M. Shcherbakov AA, et al. J Am Chem Soc. 2023 May 10;145(18):10104-10115. doi: 10.1021/jacs.3c00340. Epub 2023 Apr 25. J Am Chem Soc. 2023. PMID: 37097985 Free PMC article.
The bacterial transporter EmrE is a homo-dimeric membrane protein that effluxes cationic polyaromatic substrates against the concentration gradient by coupling to proton transport. ...We recently determined high-resolution structures of EmrE in complex with a cation …
The bacterial transporter EmrE is a homo-dimeric membrane protein that effluxes cationic polyaromatic substrates against the concentr …
Dementia in Parkinson's disease.
Hanagasi HA, Tufekcioglu Z, Emre M. Hanagasi HA, et al. J Neurol Sci. 2017 Mar 15;374:26-31. doi: 10.1016/j.jns.2017.01.012. Epub 2017 Jan 5. J Neurol Sci. 2017. PMID: 28088312 Review.
Structural Mechanism of EMRE-Dependent Gating of the Human Mitochondrial Calcium Uniporter.
Wang Y, Nguyen NX, She J, Zeng W, Yang Y, Bai XC, Jiang Y. Wang Y, et al. Cell. 2019 May 16;177(5):1252-1261.e13. doi: 10.1016/j.cell.2019.03.050. Epub 2019 May 9. Cell. 2019. PMID: 31080062 Free PMC article.
While MCU alone can transport Ca(2+) in primitive eukaryotes, metazoans require an essential single membrane-spanning auxiliary component called EMRE to form functional channels; however, the molecular mechanism of EMRE regulation remains elusive. Here, we present t …
While MCU alone can transport Ca(2+) in primitive eukaryotes, metazoans require an essential single membrane-spanning auxiliary component ca …
2,671 results