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195 results

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Page 1
Showing results for pic setting
Search for Eric Hetting instead (2 results)
TOP1 Mutations and Cross-Resistance to Antibody-Drug Conjugates in Patients with Metastatic Breast Cancer.
Abelman RO, Wu B, Barnes H, Medford A, Norden B, Putur A, Bitman E, Thant W, Liu T, Weipert C, Fell G, Spring LM, Wander SA, Moy B, Vidula N, Isakoff SJ, Varkaris A, Juric D, Corcoran RB, Ellisen LW, Bardia A. Abelman RO, et al. Clin Cancer Res. 2025 May 15;31(10):1966-1974. doi: 10.1158/1078-0432.CCR-24-2771. Clin Cancer Res. 2025. PMID: 39745368 Free PMC article.
In this study, we report the incidence and characterization of TOP1 mutations arising in the setting of ADC resistance in metastatic breast cancer. EXPERIMENTAL DESIGN: Patients with metastatic breast cancer treated with ADCs with available posttreatment plasma-based genot …
In this study, we report the incidence and characterization of TOP1 mutations arising in the setting of ADC resistance in metastatic …
Effect of Capivasertib in Patients With an AKT1 E17K-Mutated Tumor: NCI-MATCH Subprotocol EAY131-Y Nonrandomized Trial.
Kalinsky K, Hong F, McCourt CK, Sachdev JC, Mitchell EP, Zwiebel JA, Doyle LA, McShane LM, Li S, Gray RJ, Rubinstein LV, Patton D, Williams PM, Hamilton SR, Conley BA, O'Dwyer PJ, Harris LN, Arteaga CL, Chen AP, Flaherty KT. Kalinsky K, et al. JAMA Oncol. 2021 Feb 1;7(2):271-278. doi: 10.1001/jamaoncol.2020.6741. JAMA Oncol. 2021. PMID: 33377972 Free PMC article. Clinical Trial.
OBJECTIVE: To assess the objective response rate (ORR) of capivasertib in patients with an AKT1 E17K-mutated tumor. DESIGN, SETTING, AND PARTICIPANTS: Between July 13, 2016, and August 10, 2017, patients in the NCI-MATCH trial were enrolled and assigned to the subprotocol …
OBJECTIVE: To assess the objective response rate (ORR) of capivasertib in patients with an AKT1 E17K-mutated tumor. DESIGN, SETTING, …
Effects of sleep deprivation on sports performance and perceived exertion in athletes and non-athletes: a systematic review and meta-analysis.
Kong Y, Yu B, Guan G, Wang Y, He H. Kong Y, et al. Front Physiol. 2025 Apr 1;16:1544286. doi: 10.3389/fphys.2025.1544286. eCollection 2025. Front Physiol. 2025. PMID: 40236824 Free PMC article.
These findings are crucial for understanding how sleep deprivation impacts both athletes and non-athletes, particularly in the context of training and competitive settings....
These findings are crucial for understanding how sleep deprivation impacts both athletes and non-athletes, particularly in the context of tr …
Eganelisib combined with immune checkpoint inhibitor therapy and chemotherapy in frontline metastatic triple-negative breast cancer triggers macrophage reprogramming, immune activation and extracellular matrix reorganization in the tumor microenvironment.
O'Connell BC, Hubbard C, Zizlsperger N, Fitzgerald D, Kutok JL, Varner J, Ilaria R Jr, Cobleigh MA, Juric D, Tkaczuk KHR, Elias A, Lee A, Dakhil S, Hamilton E, Soliman H, Peluso S. O'Connell BC, et al. J Immunother Cancer. 2024 Aug 30;12(8):e009160. doi: 10.1136/jitc-2024-009160. J Immunother Cancer. 2024. PMID: 39214650 Free PMC article. Clinical Trial.
BACKGROUND: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with a poor prognosis particularly in the metastatic setting. Treatments with anti-programmed cell death protein-1/programmed death-ligand 1 (PD-L1) immune checkpoint inhibitors (ICI …
BACKGROUND: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with a poor prognosis particularly in the metasta …
Inavolisib plus letrozole or fulvestrant in PIK3CA-mutated, hormone receptor-positive, HER2-negative advanced or metastatic breast cancer (GO39374): An open-label, multicentre, dose-escalation and dose-expansion phase 1/1b study.
Bedard PL, Jhaveri KL, Accordino MK, Cervantes PA, Gambardella V, Hamilton E, Italiano PA, Kalinsky PK, Krop PIE, Oliveira M, Schmid PP, Saura C, Turner PN, Varga A, Cheeti S, Dey A, Hilz S, Hutchinson KE, Jin Y, Royer-Joo S, Peters U, Shankar N, Schutzman JL, Aimi J, Song K, Juric D. Bedard PL, et al. Eur J Cancer. 2025 May 15;221:115397. doi: 10.1016/j.ejca.2025.115397. Epub 2025 Mar 30. Eur J Cancer. 2025. PMID: 40203765 Free article. Clinical Trial.
BACKGROUND: A variety of treatment options continue to be explored in the post-cyclin-dependent kinase 4/6 inhibitor (CDK4/6i) setting for hormone receptor (HR)-positive, HER2-negative locally advanced/metastatic breast cancer (LA/mBC), and optimal sequencing of therapies …
BACKGROUND: A variety of treatment options continue to be explored in the post-cyclin-dependent kinase 4/6 inhibitor (CDK4/6i) setting …
HIV-1 vector systems.
Srinivasakumar N. Srinivasakumar N. Somat Cell Mol Genet. 2001 Nov;26(1-6):51-81. doi: 10.1023/a:1021074613196. Somat Cell Mol Genet. 2001. PMID: 12465462 Review.
The reasons for increased ability of lentivirus vectors to transduce such cells has been attributed to several of the viral proteins (integrase, matrix and Vpr) that are purported to be involved in the nuclear import of the pre-integration complex (PIC). Nuclear import is …
The reasons for increased ability of lentivirus vectors to transduce such cells has been attributed to several of the viral proteins (integr …
Minimum Imaging Sets for Diagnosis, Activity Assessment, and Complications in Noninfectious Posterior Uveitis - Multimodal Imaging in Uveitis (MUV) Task Force Report 9.
Invernizzi A, Agarwal A, Gangaputra S, Airaldi M, Carreno E, Munk MR, Pichi F, Shantha J, Agrawal R, Sadda S, Jampol LM, Smith JR, Jabs DA, Chee SP, Sarraf D, Gupta V; Multimodal Imaging in Uveitis (MUV) Task Force. Invernizzi A, et al. Am J Ophthalmol. 2025 Dec;280:106-119. doi: 10.1016/j.ajo.2025.07.029. Epub 2025 Aug 5. Am J Ophthalmol. 2025. PMID: 40754260 Free article.
METHODS: Five groups of uveitis experts were selected by the Multimodal Imaging in Uveitis (MUV) taskforce and asked to create an MIS for each of the following entities: multiple evanescent white dots syndrome (MEWDS), acute posterior multifocal placoid pigment epitheliopathy (AP …
METHODS: Five groups of uveitis experts were selected by the Multimodal Imaging in Uveitis (MUV) taskforce and asked to create an MIS for ea …
Neural Circuits of Fear and Anxiety: Insights from a Neuroethological Perspective.
Melleu FF, Canteras NS. Melleu FF, et al. Physiology (Bethesda). 2025 May 1;40(3):0. doi: 10.1152/physiol.00042.2024. Epub 2024 Dec 11. Physiology (Bethesda). 2025. PMID: 39661324 Review.
The PIC is divided into three different sequential stages that reflect defensive behavioral strategy in response to predatory imminence. ...In this article, we consider the PIC in a more naturalistic behavioral setting, focusing on analyzing the neural system …
The PIC is divided into three different sequential stages that reflect defensive behavioral strategy in response to predatory imminen …
Analysis of safety and efficacy of proton radiotherapy for optic nerve sheath meningioma.
Deng MY, Rauh S, Anil G, Lischalk JW, Hahnemann L, Eichkorn T, Hörner-Rieber J, Paul A, Sandrini E, Hoegen-Sassmannshausen P, Held T, Regnery S, Bauer L, Sahm F, von Deimling A, Wick A, Wick W, Jungk C, Krieg SM, Herfarth K, Debus J, König L. Deng MY, et al. Neurooncol Adv. 2024 Sep 21;6(1):vdae160. doi: 10.1093/noajnl/vdae160. eCollection 2024 Jan-Dec. Neurooncol Adv. 2024. PMID: 39434923 Free PMC article.
Future head-to-head comparisons with photon radiotherapy in a prospective setting are required to demonstrate a potential, additional clinical benefit....
Future head-to-head comparisons with photon radiotherapy in a prospective setting are required to demonstrate a potential, additional …
Paediatric integrated care in the primary care setting: A scoping review of populations served, models used and outcomes measured.
McLeigh JD, Malthaner L, Winebrenner C, Stone KE. McLeigh JD, et al. Child Care Health Dev. 2022 Sep;48(5):869-879. doi: 10.1111/cch.13000. Epub 2022 Mar 28. Child Care Health Dev. 2022. PMID: 35288973
Thus, this study seeks to better understand (1) what paediatric subpopulations are receiving integrated care, (2) which models of PIC are being studied, (3) what PIC outcomes are being explored and what measures and strategies are being used to assess those outcomes …
Thus, this study seeks to better understand (1) what paediatric subpopulations are receiving integrated care, (2) which models of PIC …
195 results