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A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models.
Singh D, Deosarkar SP, Cadogan E, Flemington V, Bray A, Zhang J, Reiserer RS, Schaffer DK, Gerken GB, Britt CM, Werner EM, Gibbons FD, Kostrzewski T, Chambers CE, Davies EJ, Montoya AR, Fok JHL, Hughes D, Fabre K, Wagoner MP, Wikswo JP, Scott CW. Singh D, et al. Among authors: werner em. PLoS Biol. 2022 May 26;20(5):e3001624. doi: 10.1371/journal.pbio.3001624. eCollection 2022 May. PLoS Biol. 2022. PMID: 35617197 Free PMC article.
A bistable, multiport valve enables microformulators creating microclinical analyzers that reveal aberrant glutamate metabolism in astrocytes derived from a tuberous sclerosis patient.
Miller DR, Schaffer DK, Neely MD, McClain ES, Travis AR, Block FE 3rd, Mckenzie J, Werner EM, Armstrong L, Markov DA, Bowman AB, Ess KC, Cliffel DE, Wikswo JP. Miller DR, et al. Among authors: werner em. Sens Actuators B Chem. 2021 Aug 15;341:129972. doi: 10.1016/j.snb.2021.129972. Epub 2021 Apr 20. Sens Actuators B Chem. 2021. PMID: 34092923 Free PMC article.