Cofilin hyperphosphorylation triggers TDP-43 pathology in sporadic amyotrophic lateral sclerosis.
Jagaraj CJ, Saravanabavan S, Parakh S, Jayakumar M, Kashani SA, Shadfar S, Mehta P, Gautam S, Farzana F, Suchowerska AK, Yap K, Vidal M, Ragagnin AMG, Jamali MS, Yang S, Fath T, Craik D, Atkin JD.
Jagaraj CJ, et al.
Brain. 2026 Mar 10:awag096. doi: 10.1093/brain/awag096. Online ahead of print.
Brain. 2026.
PMID: 41804798
Free article.
When cofilin is phosphorylated (at Serine-3) by LIM kinase1 (LIMK1), it becomes inactive, leading to production of more F-actin. Defects in cofilin are well described in other neurodegenerative disorders, unlike in ALS. ...We also show that mimicking cofilin hyperphosphory …
When cofilin is phosphorylated (at Serine-3) by LIM kinase1 (LIMK1), it becomes inactive, leading to production of more F-actin. Defe …