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68 results

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Page 1
A Randomized, Controlled Trial of the Pan-PPAR Agonist Lanifibranor in NASH.
Francque SM, Bedossa P, Ratziu V, Anstee QM, Bugianesi E, Sanyal AJ, Loomba R, Harrison SA, Balabanska R, Mateva L, Lanthier N, Alkhouri N, Moreno C, Schattenberg JM, Stefanova-Petrova D, Vonghia L, Rouzier R, Guillaume M, Hodge A, Romero-Gómez M, Huot-Marchand P, Baudin M, Richard MP, Abitbol JL, Broqua P, Junien JL, Abdelmalek MF; NATIVE Study Group. Francque SM, et al. N Engl J Med. 2021 Oct 21;385(17):1547-1558. doi: 10.1056/NEJMoa2036205. N Engl J Med. 2021. PMID: 34670042 Clinical Trial.
Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial.
Butler CC, Hobbs FDR, Gbinigie OA, Rahman NM, Hayward G, Richards DB, Dorward J, Lowe DM, Standing JF, Breuer J, Khoo S, Petrou S, Hood K, Nguyen-Van-Tam JS, Patel MG, Saville BR, Marion J, Ogburn E, Allen J, Rutter H, Francis N, Thomas NPB, Evans P, Dobson M, Madden TA, Holmes J, Harris V, Png ME, Lown M, van Hecke O, Detry MA, Saunders CT, Fitzgerald M, Berry NS, Mwandigha L, Galal U, Mort S, Jani BD, Hart ND, Ahmed H, Butler D, McKenna M, Chalk J, Lavallee L, Hadley E, Cureton L, Benysek M, Andersson M, Coates M, Barrett S, Bateman C, Davies JC, Raymundo-Wood I, Ustianowski A, Carson-Stevens A, Yu LM, Little P; PANORAMIC Trial Collaborative Group. Butler CC, et al. Lancet. 2023 Jan 28;401(10373):281-293. doi: 10.1016/S0140-6736(22)02597-1. Epub 2022 Dec 22. Lancet. 2023. PMID: 36566761 Free PMC article. Clinical Trial.
Long noncoding RNA PANDA and scaffold-attachment-factor SAFA control senescence entry and exit.
Puvvula PK, Desetty RD, Pineau P, Marchio A, Moon A, Dejean A, Bischof O. Puvvula PK, et al. Nat Commun. 2014 Nov 19;5:5323. doi: 10.1038/ncomms6323. Nat Commun. 2014. PMID: 25406515 Free PMC article.
In proliferating cells, SAFA and PANDA recruit PRC complexes to repress the transcription of senescence-promoting genes. Conversely, the loss of SAFA-PANDA-PRC interactions allows expression of the senescence programme. Accordingly, we find that depleting either …
In proliferating cells, SAFA and PANDA recruit PRC complexes to repress the transcription of senescence-promoting genes. Conversely, …
Identification of an internal cavity in the PhoQ sensor domain for PhoQ activity and SafA-mediated control.
Yoshitani K, Ishii E, Taniguchi K, Sugimoto H, Shiro Y, Akiyama Y, Kato A, Utsumi R, Eguchi Y. Yoshitani K, et al. Biosci Biotechnol Biochem. 2019 Apr;83(4):684-694. doi: 10.1080/09168451.2018.1562879. Epub 2019 Jan 11. Biosci Biotechnol Biochem. 2019. PMID: 30632929
We have previously shown that SafA directly interacts with the sensor domain of the periplasmic region of PhoQ (PhoQ-SD) for activation, and that a D179R mutation in PhoQ-SD attenuates PhoQ activation by SafA. ...Furthermore, the SD pocket has also been shown to be …
We have previously shown that SafA directly interacts with the sensor domain of the periplasmic region of PhoQ (PhoQ-SD) for activati …
Assessing Sustainability in Cattle Silvopastoral Systems in the Mexican Tropics Using the SAFA Framework.
Pérez-Lombardini F, Mancera KF, Suzán G, Campo J, Solorio J, Galindo F. Pérez-Lombardini F, et al. Animals (Basel). 2021 Jan 7;11(1):109. doi: 10.3390/ani11010109. Animals (Basel). 2021. PMID: 33430373 Free PMC article.
This work compares the sustainable performance of silvopastoral (native and intensive) and monoculture cattle farms in the state of Yucatan using the Sustainability Assessment for Food and Agriculture (SAFA) framework. Questionnaires and semi-structured interviews were app …
This work compares the sustainable performance of silvopastoral (native and intensive) and monoculture cattle farms in the state of Yucatan …
A Comprehensive Overview of Coagulation Factor V and Congenital Factor V Deficiency.
Tabibian S, Shiravand Y, Shams M, Safa M, Gholami MS, Heydari F, Ahmadi A, Rashidpanah J, Dorgalaleh A. Tabibian S, et al. Semin Thromb Hemost. 2019 Jul;45(5):523-543. doi: 10.1055/s-0039-1687906. Epub 2019 May 23. Semin Thromb Hemost. 2019. PMID: 31121608 Review.
Coagulation factor (F) V is a glycoprotein that plays an essential role in the formation of the prothrombinase complex, which is critical for progressing clot formation. ...
Coagulation factor (F) V is a glycoprotein that plays an essential role in the formation of the prothrombinase complex, which is crit …
Dupilumab significantly improves sleep in adults with atopic dermatitis: results from the 12-week placebo-controlled period of the 24-week phase IV randomized double-blinded placebo-controlled DUPISTAD study.
Merola JF, Chiou AS, During E, Costanzo A, Foley P, Alfalasi A, Gogate S, Pinter A, Dodiuk-Gad R, Simon D, Tauber M, Weller R, Pereyra-Rodriguez JJ, Ardeleanu M, Wu J, Ozturk ZE. Merola JF, et al. Br J Dermatol. 2023 Nov 16;189(6):685-694. doi: 10.1093/bjd/ljad284. Br J Dermatol. 2023. PMID: 37562034 Free article. Clinical Trial.
Low-Dose Olanzapine in the Treatment of Adolescents with Anorexia Nervosa: An Observational Naturalistic Case-Control Study.
Pruccoli J, Pettenuzzo I, Parmeggiani A. Pruccoli J, et al. J Child Adolesc Psychopharmacol. 2022 Jun;32(5):304-310. doi: 10.1089/cap.2022.0003. Epub 2022 May 24. J Child Adolesc Psychopharmacol. 2022. PMID: 35612433

Results: A total of 118 patients were enrolled (F = 94.1%; mean age = 15.4 1.7 years), including 52 controls, 37 treated with low-dose olanzapine, and 29 with full-dose olanzapine. ...The multidisciplinary intervention resulted in an improvement of BUT-GSI (p < 0.001),

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Results: A total of 118 patients were enrolled (F = 94.1%; mean age = 15.4 1.7 years), including 52 controls, 37 treated with low-dos …
68 results