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1

The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas.

Fang D, Gan H, Lee JH, Han J, Wang Z, Riester SM, Jin L, Chen J, Zhou H, Wang J, Zhang H, Yang N, Bradley EW, Ho TH, Rubin BP, Bridge JA, Thibodeau SN, Ordog T, Chen Y, van Wijnen AJ, Oliveira AM, Xu RM, Westendorf JJ, Zhang Z. Fang D, et al. Science. 2016 Jun 10;352(6291):1344-8. doi: 10.1126/science.aae0065. Epub 2016 May 26. Science. 2016. PMID: 27229140 Free PMC article.

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2

A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma.

Chen X, Zhang M, Gan H, Wang H, Lee JH, Fang D, Kitange GJ, He L, Hu Z, Parney IF, Meyer FB, Giannini C, Sarkaria JN, Zhang Z. Chen X, et al. Among authors: Fang D. Nat Commun. 2018 Jul 27;9(1):2949. doi: 10.1038/s41467-018-05373-4. Nat Commun. 2018. PMID: 30054476 Free PMC article.

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3

Structural insight into substrate preference for TET-mediated oxidation.

Hu L, Lu J, Cheng J, Rao Q, Li Z, Hou H, Lou Z, Zhang L, Li W, Gong W, Liu M, Sun C, Yin X, Li J, Tan X, Wang P, Wang Y, Fang D, Cui Q, Yang P, He C, Jiang H, Luo C, Xu Y. Hu L, et al. Among authors: Fang D. Nature. 2015 Nov 5;527(7576):118-22. doi: 10.1038/nature15713. Epub 2015 Oct 28. Nature. 2015. PMID: 26524525

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4

Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma.

Hashizume R, Andor N, Ihara Y, Lerner R, Gan H, Chen X, Fang D, Huang X, Tom MW, Ngo V, Solomon D, Mueller S, Paris PL, Zhang Z, Petritsch C, Gupta N, Waldman TA, James CD. Hashizume R, et al. Among authors: Fang D. Nat Med. 2014 Dec;20(12):1394-6. doi: 10.1038/nm.3716. Epub 2014 Nov 17. Nat Med. 2014. PMID: 25401693 Free PMC article.

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5

TGF-β-induced transgelin promotes bladder cancer metastasis by regulating epithelial-mesenchymal transition and invadopodia formation.

Chen Z, He S, Zhan Y, He A, Fang D, Gong Y, Li X, Zhou L. Chen Z, et al. Among authors: Fang D. EBioMedicine. 2019 Sep;47:208-220. doi: 10.1016/j.ebiom.2019.08.012. Epub 2019 Aug 13. EBioMedicine. 2019. PMID: 31420300 Free PMC article.

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6

Cancer stem cells and epithelial-mesenchymal transition in urothelial carcinoma: Possible pathways and potential therapeutic approaches.

Fang D, Kitamura H. Fang D, et al. Int J Urol. 2018 Jan;25(1):7-17. doi: 10.1111/iju.13404. Epub 2017 Jul 11. Int J Urol. 2018. PMID: 28697535 Free article. Review.

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7

FuFangChangTai Decoction Activates Macrophages via Inducing Autophagy.

Li L, Wang H, Qian J, Wei G, Ding R, Hu C, Fang D, Jiang Z, Bi L, Song J, Ma J, Qin F, Huang X, Cao M, Huo J. Li L, et al. Among authors: Fang D. Evid Based Complement Alternat Med. 2019 Jun 12;2019:5657035. doi: 10.1155/2019/5657035. eCollection 2019. Evid Based Complement Alternat Med. 2019. PMID: 31308853 Free PMC article.

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8

Impact of ureteroscopy before radical nephroureterectomy for upper tract urothelial carcinomas on oncological outcomes: a meta-analysis.

Guo RQ, Hong P, Xiong GY, Zhang L, Fang D, Li XS, Zhang K, Zhou LQ. Guo RQ, et al. Among authors: Fang D. BJU Int. 2018 Feb;121(2):184-193. doi: 10.1111/bju.14053. Epub 2017 Nov 1. BJU Int. 2018. PMID: 29032580 Free article. Review.

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9

Live-cell single-molecule dynamics of PcG proteins imposed by the DIPG H3.3K27M mutation.

Tatavosian R, Duc HN, Huynh TN, Fang D, Schmitt B, Shi X, Deng Y, Phiel C, Yao T, Zhang Z, Wang H, Ren X. Tatavosian R, et al. Among authors: Fang D. Nat Commun. 2018 May 25;9(1):2080. doi: 10.1038/s41467-018-04455-7. Nat Commun. 2018. PMID: 29802243 Free PMC article.

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10

H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers.

Fang D, Gan H, Cheng L, Lee JH, Zhou H, Sarkaria JN, Daniels DJ, Zhang Z. Fang D, et al. Elife. 2018 Jun 22;7:e36696. doi: 10.7554/eLife.36696. Elife. 2018. PMID: 29932419 Free PMC article.

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