Clostridioides difficile colonization is not mediated by bile salts and utilizes Stickland fermentation of proline in an in vitro model.
Huang X, Johnson AE, Brehm JN, Do TVT, Auchtung TA, McCullough HC, Lerma AI, Haidacher SJ, Hoch KM, Horvath TD, Sorg JA, Haag AM, Auchtung JM.
Huang X, et al.
mSphere. 2025 Feb 25;10(2):e0104924. doi: 10.1128/msphere.01049-24. Epub 2025 Jan 16.
mSphere. 2025.
PMID: 39817755
Free PMC article.
Furthermore, bile salts were not required to inhibit C. difficile colonization. We tested whether amino acid fermentation contributed to the persistence of C. difficile in antibiotic-treated communities. C. difficile mutants unable to use proline as an electron acceptor in …
Furthermore, bile salts were not required to inhibit C. difficile colonization. We tested whether amino acid fermentation contributed …