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Exenatide once weekly versus placebo in Parkinson's disease: a randomised, double-blind, placebo-controlled trial.
Athauda D, Maclagan K, Skene SS, Bajwa-Joseph M, Letchford D, Chowdhury K, Hibbert S, Budnik N, Zampedri L, Dickson J, Li Y, Aviles-Olmos I, Warner TT, Limousin P, Lees AJ, Greig NH, Tebbs S, Foltynie T. Athauda D, et al. Lancet. 2017 Oct 7;390(10103):1664-1675. doi: 10.1016/S0140-6736(17)31585-4. Epub 2017 Aug 3. Lancet. 2017. PMID: 28781108 Free PMC article. Clinical Trial.
Six serious adverse events occurred in the exenatide group and two in the placebo group, although none in either group were judged to be related to the study interventions. INTERPRETATION: Exenatide had positive effects on practically defined off-medication motor scores in …
Six serious adverse events occurred in the exenatide group and two in the placebo group, although none in either group were judged to …
Effectiveness and safety of opicapone in Parkinson's disease patients with motor fluctuations: the OPTIPARK open-label study.
Reichmann H, Lees A, Rocha JF, Magalhães D, Soares-da-Silva P; OPTIPARK investigators. Reichmann H, et al. Transl Neurodegener. 2020 Mar 4;9(1):9. doi: 10.1186/s40035-020-00187-1. Transl Neurodegener. 2020. PMID: 32345378 Free PMC article. Clinical Trial.
METHODS: OPTIPARK (NCT02847442) was a prospective, open-label, single-arm trial conducted in Germany and the UK under clinical practice conditions. Patients with Parkinson's disease and motor fluctuations were treated with opicapone 50 mg for 3 (Germany) or 6 (UK) months i …
METHODS: OPTIPARK (NCT02847442) was a prospective, open-label, single-arm trial conducted in Germany and the UK under clinical practice cond …
3D printing and high tibial osteotomy.
Jones GG, Jaere M, Clarke S, Cobb J. Jones GG, et al. EFORT Open Rev. 2018 May 21;3(5):254-259. doi: 10.1302/2058-5241.3.170075. eCollection 2018 May. EFORT Open Rev. 2018. PMID: 29951264 Free PMC article.
Thus far, the outcomes have been variable, and apparently worse than the arthroplasty alternatives when judged using conventional metrics, owing in large part to uncertainty around the extent of the correction planned and achieved.This review paper introduces the concept o …
Thus far, the outcomes have been variable, and apparently worse than the arthroplasty alternatives when judged using conventional met …
Cryo-Electron Microscopy Structure of the αIIbβ3-Abciximab Complex.
Nešić D, Zhang Y, Spasic A, Li J, Provasi D, Filizola M, Walz T, Coller BS. Nešić D, et al. Arterioscler Thromb Vasc Biol. 2020 Mar;40(3):624-637. doi: 10.1161/ATVBAHA.119.313671. Epub 2020 Jan 23. Arterioscler Thromb Vasc Biol. 2020. PMID: 31969014 Free PMC article.
Unexpectedly, the structure also indicated several interactions with alphaIIb. As judged by the cryo-electron microscopy model, molecular-dynamics simulations, and mutagenesis, the binding of abciximab does not appear to rely on the interaction with the alphaIIb residues a …
Unexpectedly, the structure also indicated several interactions with alphaIIb. As judged by the cryo-electron microscopy model, molec …
Colloid solutions for fluid resuscitation.
Bunn F, Alderson P, Hawkins V. Bunn F, et al. Cochrane Database Syst Rev. 2001;(2):CD001319. doi: 10.1002/14651858.CD001319. Cochrane Database Syst Rev. 2001. PMID: 11405985 Updated. Review.
MAIN RESULTS: 52 trials met the inclusion criteria, with a total of 3311 participants. Quality of allocation concealment was judged to be adequate in 17 trials and poor or uncertain in 35. Deaths were obtained from 31 trials. ...Fifteen trials recorded adverse reactions, b …
MAIN RESULTS: 52 trials met the inclusion criteria, with a total of 3311 participants. Quality of allocation concealment was judged t …
Proceedings of the 3rd Biennial Conference of the Society for Implementation Research Collaboration (SIRC) 2015: advancing efficient methodologies through community partnerships and team science : Seattle, WA, USA. 24-26 September 2015.
Lewis C, Darnell D, Kerns S, Monroe-DeVita M, Landes SJ, Lyon AR, Stanick C, Dorsey S, Locke J, Marriott B, Puspitasari A, Dorsey C, Hendricks K, Pierson A, Fizur P, Comtois KA, Palinkas LA, Chamberlain P, Aarons GA, Green AE, Ehrhart MG, Trott EM, Willging CE, Fernandez ME, Woolf NH, Liang SL, Heredia NI, Kegler M, Risendal B, Dwyer A, Young V, Campbell D, Carvalho M, Kellar-Guenther Y, Damschroder LJ, Lowery JC, Ono SS, Carlson KF, Cottrell EK, O’Neil ME, Lovejoy TL, Arch JJ, Mitchell JL, Lewis CC, Marriott BR, Scott K, Coldiron JS, Bruns EJ, Hook AN, Graham BC, Jordan K, Hanson RF, Moreland A, Saunders BE, Resnick HS, Stirman SW, Gutner CA, Gamarra J, Vogt D, Suvak M, Wachen JS, Dondanville K, Yarvis JS, Mintz J, Peterson AL, Borah EV, Litz BT, Molino A, McCaughan SY, Resick PA, Pandhi N, Jacobson N, Serrano N, Hernandez A, Schreiter EZ, Wietfeldt N, Karp Z, Pullmann MD, Lucenko B, Pavelle B, Uomoto JA, Negrete A, Cevasco M, Kerns SEU, Franks RP, Bory C, Miech EJ, Damush TM, Satterfield J, Satre D, Wamsley M, Yuan P, O’Sullivan P, Best H, Velasquez S, Barnett M, Brookman-Frazee L, Regan J, Stadnick N, Hamilton A, Lau A, Regan J, Hamilton A, Stadnick N, Barnett M, Lau A, Brookman-Frazee L, Stadnick N, Lau A, Barnett M, Regan J, Roesch S, Brookman-Frazee L, Powell BJ, Waltz TJ, Chinman MJ, Damschroder L, Smith JL, Matthieu MM, Proctor EK, Kirchner JE, Waltz TJ, Powell BJ, Chinman MJ, Damschroder LJ, Smith JL, Matthieu MJ, Proctor EK, Kirchner JE, Matthieu MM, Rosen CS, Waltz TJ, Powell BJ, Chinman MJ, Damschroder LJ, Smith JL, Proctor EK, Kirchner JE, Walker SC, Bishop AS, Lockhart M, Rodriguez AL, Manfredi L, Nevedal A, Rosenthal J, Blonigen DM, Mauricio AM, Dishion TD, Rudo-Stern J, Smith JD, Locke J, Wolk CB, Harker C, Olsen A, Shingledecker T, Barg F, Mandell D, Beidas RS, Hansen MC, Aranda MP, Torres-Vigil I, Hartzler B, Steinfeld B, Gildred T, Harlin Z, Shephard F, Ditty MS, Doyle A, Bickel JA III, Cristaudo K, Fox D, Combs S, Lischner DH, Van Dorn RA, Tueller SJ, Hinde JM, Karuntzos GT, Monroe-DeVita M, Peterson R, Darnell D, Berliner L, Dorsey S, Murray LK, Botanov Y, Kikuta B, Chen T, Navarro-Haro M, DuBose A, Korslund KE, Linehan MM, Harker CM, Karp EA, Edmunds SR, Ibañez LV, Stone WL, Andrews JH, Johnides BD, Hausman EM, Hawley KM, Prusaczyk B, Ramsey A, Baumann A, Colditz G, Proctor EK, Botanov Y, Kikuta B, Chen T, Navarro-Haro M, DuBose A, Korslund KE, Linehan MM, Harker CM, Karp EA, Edmunds SR, Ibañez LV, Stone WL, Choy-Brown M, Andrews JH, Johnides BD, Hausman EM, Hawley KM, Prusaczyk B, Ramsey A, Baumann A, Colditz G, Proctor EK, Meza RD, Dorsey S, Wiltsey-Stirman S, Sedlar G, Lucid L, Dorsey C, Marriott B, Zounlome N, Lewis C, Gutner CA, Monson CM, Shields N, Mastlej M, Landy MSH, Lane J, Stirman SW, Finn NK, Torres EM, Ehrhart MG, Aarons GA, Malte CA, Lott A, Saxon AJ, Boyd M, Scott K, Lewis CC, Pierce JD, Lorthios-Guilledroit A, Richard L, Filiatrault J, Hallgren K, Crotwell S, Muñoz R, Gius B, Ladd B, McCrady B, Epstein E, Clapp JD, Ruderman DE, Barwick M, Barac R, Zlotkin S, Salim L, Davidson M, Bunger AC, Powell BJ, Robertson HA, Botsko C, Landes SJ, Smith BN, Rodriguez AL, Trent LR, Matthieu MM, Powell BJ, Proctor EK, Harned MS, Navarro-Haro M, Korslund KE, Chen T, DuBose A, Ivanoff A, Linehan MM, Garcia AR, Kim M, Palinkas LA, Snowden L, Landsverk J, Sweetland AC, Fernandes MJ, Santos E, Duarte C, Kritski A, Krawczyk N, Nelligan C, Wainberg ML, Aarons GA, Sommerfeld DH, Chi B, Ezeanolue E, Sturke R, Kline L, Guay L, Siberry G, Bennett IM, Beidas R, Gold R, Mao J, Powers D, Vredevoogd M, Unutzer J, Schroeder J, Volpe L, Steffen J, Dorsey S, Pullmann MD, Kerns SEU, Jungbluth N, Berliner L, Thompson K, Segell E, McGee-Vincent P, Liu N, Walser R, Runnals J, Shaw RK, Landes SJ, Rosen C, Schmidt J, Calhoun P, Varkovitzky RL, Landes SJ, Drahota A, Martinez JI, Brikho B, Meza R, Stahmer AC, Aarons GA, Williamson A, Rubin RM, Powell BJ, Hurford MO, Weaver SL, Beidas RS, Mandell DS, Evans AC, Powell BJ, Beidas RS, Rubin RM, Stewart RE, Wolk CB, Matlin SL, Weaver S, Hurford MO, Evans AC, Hadley TR, Mandell DS, Gerke DR, Prusaczyk B, Baumann A, Lewis EM, Proctor EK, McWilliam J, Brown J, Tucker M, Conte KP, Lyon AR, Boyd M, Melvin A, Lewis CC, Liu F, Jungbluth N, Kotte A, Hill KA, Mah AC, Korathu-Larson PA, Au JR, Izmirian S, Keir S, Nakamura BJ, Higa-McMillan CK, Cooper BR, Funaiole A, Dizon E, Hawkins EJ, Malte CA, Hagedorn HJ, Berger D, Frank A, Lott A, Achtmeyer CE, Mariano AJ, Saxon AJ, Wolitzky-Taylor K, Rawson R, Ries R, Roy-Byrne P, Craske M, Simmons D, Torrente C, Nathanson L, Carroll G, Smith JD, Brown K, Ramos K, Thornton N, Dishion TJ, Stormshak EA, Shaw DS, Wilson MN, Choy-Brown M, Tiderington E, Smith BT, Padgett DK, Rubin RM, Ray ML, Wandersman A, Lamont A, Hannah G, Alia KA, Hurford MO, Evans AC, Saldana L, Schaper H, Campbell M, Chamberlain P, Shapiro VB, Kim BKE, Fleming JL, LeBuffe PA, Landes SJ, Lewis CC, Rodriguez AL, Marriott BR, Comtois KA, Lewis CC, Stanick C, Weiner BJ, Halko H, Dorsey C. Lewis C, et al. Implement Sci. 2016 Jun 23;11 Suppl 1(Suppl 1):85. doi: 10.1186/s13012-016-0428-0. Implement Sci. 2016. PMID: 27357964 Free PMC article.
Matthieu A56: Learning from implementation as usual in children's mental health Byron J. Powell, Enola K. Proctor A57: Rates and predictors of implementation after Dialectical Behavior Therapy Intensive Training Melanie S. ...Powell, Matthew O. Hurford, Shawna L. We …
Matthieu A56: Learning from implementation as usual in children's mental health Byron J. Powell, Enola K. Proctor A57: Rates and pred …
Codeine, alone and with paracetamol (acetaminophen), for cancer pain.
Straube C, Derry S, Jackson KC, Wiffen PJ, Bell RF, Strassels S, Straube S. Straube C, et al. Cochrane Database Syst Rev. 2014 Sep 19;2014(9):CD006601. doi: 10.1002/14651858.CD006601.pub4. Cochrane Database Syst Rev. 2014. PMID: 25234029 Free PMC article. Review.
The included studies were of adequate methodological quality, but all except for one were judged to be at a high risk of bias because of small study size, and six because of methods used to deal with missing data or high withdrawal rates. ...
The included studies were of adequate methodological quality, but all except for one were judged to be at a high risk of bias because …
A role for judges in assisted dying.
Castelló A, Francès F, Verdú F. Castelló A, et al. J Med Ethics Hist Med. 2009 May 30;2:3. Print 2009. J Med Ethics Hist Med. 2009. PMID: 23908717 Free PMC article.
Novel Pure αVβ3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations.
Li J, Fukase Y, Shang Y, Zou W, Muñoz-Félix JM, Buitrago L, van Agthoven J, Zhang Y, Hara R, Tanaka Y, Okamoto R, Yasui T, Nakahata T, Imaeda T, Aso K, Zhou Y, Locuson C, Nesic D, Duggan M, Takagi J, Vaughan RD, Walz T, Hodivala-Dilke K, Teitelbaum SL, Arnaout MA, Filizola M, Foley MA, Coller BS. Li J, et al. ACS Pharmacol Transl Sci. 2019 Aug 2;2(6):387-401. doi: 10.1021/acsptsci.9b00041. eCollection 2019 Dec 13. ACS Pharmacol Transl Sci. 2019. PMID: 32259072 Free PMC article.
Both compounds inhibit alphaVbeta3-mediated cell adhesion to alphaVbeta3 ligands, but do not induce the conformational change as judged by antibody binding, electron microscopy, X-ray crystallography, and receptor priming studies. ...Neither, however, had the unfavorable p …
Both compounds inhibit alphaVbeta3-mediated cell adhesion to alphaVbeta3 ligands, but do not induce the conformational change as judged
Rehospitalization in a national population of home health care patients with heart failure.
Madigan EA, Gordon NH, Fortinsky RH, Koroukian SM, Piña I, Riggs JS. Madigan EA, et al. Health Serv Res. 2012 Dec;47(6):2316-38. doi: 10.1111/j.1475-6773.2012.01416.x. Epub 2012 Apr 23. Health Serv Res. 2012. PMID: 22524242 Free PMC article.
Factors with the strongest association with rehospitalization were consistent between the multilevel model and Cox proportional hazard models: number of prior hospital stays, higher HHC visit intensity category, and dyspnea severity at HHC admission. Substantial numbers of rehosp …
Factors with the strongest association with rehospitalization were consistent between the multilevel model and Cox proportional hazard model …
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