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High-throughput screening for the identification of dual inhibitors of BRD4 and RIPK3 toward the development of small-molecule medical countermeasure agents against arsenicals.
Yatchang MF, Zhai L, Moukha-Chafiq O, Mathew B, Abir FA, Zhang S, Ruiz P, McKellip S, Nebane M, Chen JY, Agarwal A, Bostwick JR, Suto MJ, Athar M, Augelli-Szafran CE. Yatchang MF, et al. Among authors: abir fa. SLAS Discov. 2025 Sep;35:100247. doi: 10.1016/j.slasd.2025.100247. Epub 2025 Jul 2. SLAS Discov. 2025. PMID: 40614822 Free article.
Design, synthesis and evaluation of novel BRD4 and RIPK3 dual inhibitors as potential anti-inflammatory agents and antidotes for arsenicals.
Moukha-Chafiq O, Yatchang MF, Houghtling K, Cantor D, Tillotson JP, Sarngadharan SC, Al Abir F, Chen JY, Zhang S, Zhai L, Vinson P, Agarwal A, Athar M, Augelli-Szafran CE. Moukha-Chafiq O, et al. Among authors: al abir f. Bioorg Med Chem Lett. 2026 Apr 9;137:130653. doi: 10.1016/j.bmcl.2026.130653. Online ahead of print. Bioorg Med Chem Lett. 2026. PMID: 41966492