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Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release.
Suofu Y, Li W, Jean-Alphonse FG, Jia J, Khattar NK, Li J, Baranov SV, Leronni D, Mihalik AC, He Y, Cecon E, Wehbi VL, Kim J, Heath BE, Baranova OV, Wang X, Gable MJ, Kretz ES, Di Benedetto G, Lezon TR, Ferrando LM, Larkin TM, Sullivan M, Yablonska S, Wang J, Minnigh MB, Guillaumet G, Suzenet F, Richardson RM, Poloyac SM, Stolz DB, Jockers R, Witt-Enderby PA, Carlisle DL, Vilardaga JP, Friedlander RM. Suofu Y, et al. Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):E7997-E8006. doi: 10.1073/pnas.1705768114. Epub 2017 Sep 5. Proc Natl Acad Sci U S A. 2017. PMID: 28874589 Free PMC article.
G protein-coupled receptors (GPCRs) are classically characterized as cell-surface receptors transmitting extracellular signals into cells. Here we show that central components of a GPCR signaling system comprised of the melatonin type 1 receptor (MT(1)), its associated
G protein-coupled receptors (GPCRs) are classically characterized as cell-surface receptors transmitting extracellular signals into c
S29434, a Quinone Reductase 2 Inhibitor: Main Biochemical and Cellular Characterization.
Boutin JA, Bouillaud F, Janda E, Gacsalyi I, Guillaumet G, Hirsch EC, Kane DA, Nepveu F, Reybier K, Dupuis P, Bertrand M, Chhour M, Le Diguarher T, Antoine M, Brebner K, Da Costa H, Ducrot P, Giganti A, Goswami V, Guedouari H, Michel PP, Patel A, Paysant J, Stojko J, Viaud-Massuard MC, Ferry G. Boutin JA, et al. Mol Pharmacol. 2019 Mar;95(3):269-285. doi: 10.1124/mol.118.114231. Epub 2018 Dec 19. Mol Pharmacol. 2019. PMID: 30567956 Free article.
Species Distribution Modelling: Contrasting presence-only models with plot abundance data.
Gomes VHF, IJff SD, Raes N, Amaral IL, Salomão RP, de Souza Coelho L, de Almeida Matos FD, Castilho CV, de Andrade Lima Filho D, López DC, Guevara JE, Magnusson WE, Phillips OL, Wittmann F, de Jesus Veiga Carim M, Martins MP, Irume MV, Sabatier D, Molino JF, Bánki OS, da Silva Guimarães JR, Pitman NCA, Piedade MTF, Mendoza AM, Luize BG, Venticinque EM, de Leão Novo EMM, Vargas PN, Silva TSF, Manzatto AG, Terborgh J, Reis NFC, Montero JC, Casula KR, Marimon BS, Marimon BH, Coronado ENH, Feldpausch TR, Duque A, Zartman CE, Arboleda NC, Killeen TJ, Mostacedo B, Vasquez R, Schöngart J, Assis RL, Medeiros MB, Simon MF, Andrade A, Laurance WF, Camargo JL, Demarchi LO, Laurance SGW, de Sousa Farias E, Nascimento HEM, Revilla JDC, Quaresma A, Costa FRC, Vieira ICG, Cintra BBL, Castellanos H, Brienen R, Stevenson PR, Feitosa Y, Duivenvoorden JF, Aymard C GA, Mogollón HF, Targhetta N, Comiskey JA, Vicentini A, Lopes A, Damasco G, Dávila N, García-Villacorta R, Levis C, Schietti J, Souza P, Emilio T, Alonso A, Neill D, Dallmeier F, Ferreira LV, Araujo-Murakami A, Praia D, do Amaral DD, Carvalho FA, de Souza FC, Feeley K, Arroyo L, Pansonato MP, Gribel R, Villa B, Licona JC, Fine PVA, Cerón C, Baraloto C, Jimenez EM, Stropp J, Engel J, Silveira M, Mora MCP, Petronelli P, Maas P, Thomas-Caesar R, Henkel TW, Daly D, Paredes MR, Baker TR, Fuentes A, Peres CA, Chave J, Pena JLM, Dexter KG, Silman MR, Jørgensen PM, Pennington T, Di Fiore A, Valverde FC, Phillips JF, Rivas-Torres G, von Hildebrand P, van Andel TR, Ruschel AR, Prieto A, Rudas A, Hoffman B, Vela CIA, Barbosa EM, Zent EL, Gonzales GPG, Doza HPD, de Andrade Miranda IP, Guillaumet JL, Pinto LFM, de Matos Bonates LC, Silva N, Gómez RZ, Zent S, Gonzales T, Vos VA, Malhi Y, Oliveira AA, Cano A, Albuquerque BW, Vriesendorp C, Correa DF, Torre EV, van der Heijden G, Ramirez-Angulo H, Ramos JF, Young KR, Rocha M, Nascimento MT, Medina MNU, Tirado M, Wang O, Sierra R, Torres-Lezama A, Mendoza C, Ferreira C, Baider C, Villarroel D, Balslev H, Mesones I, Giraldo LEU, Casas LF, Reategui MAA, Linares-Palomino R, Zagt R, Cárdenas S, Farfan-Rios W, Sampaio AF, Pauletto D, Sandoval EHV, Arevalo FR, Huamantupa-Chuquimaco I, Garcia-Cabrera K, Hernandez L, Gamarra LV, Alexiades MN, Pansini S, Cuenca WP, Milliken W, Ricardo J, Lopez-Gonzalez G, Pos E, Ter Steege H. Gomes VHF, et al. Sci Rep. 2018 Jan 17;8(1):1003. doi: 10.1038/s41598-017-18927-1. Sci Rep. 2018. PMID: 29343741 Free PMC article.
Our pipeline provides a conservative estimate of a species' area of occupancy, within an area slightly larger than its extent of occurrence, compatible to e.g. ...
Our pipeline provides a conservative estimate of a species' area of occupancy, within an area slightly larger than its extent of occurrence, …
Phenotypic variation in Galerida larks in Morocco: the role of history and natural selection.
Guillaumet A, Crochet PA, Godelle B. Guillaumet A, et al. Mol Ecol. 2005 Oct;14(12):3809-21. doi: 10.1111/j.1365-294X.2005.02696.x. Mol Ecol. 2005. PMID: 16202098
In G. theklae, there was no further subdivision, while in G. cristata two major mtDNA groups were identified (divergence approximately 1.1 Ma). ...Patterns of morphological variation were then contrasted to this pattern of neutral relationships: we found that G
In G. theklae, there was no further subdivision, while in G. cristata two major mtDNA groups were identified (divergence appro …
Design and validation of the first cell-impermeant melatonin receptor agonist.
Gbahou F, Cecon E, Viault G, Gerbier R, Jean-Alphonse F, Karamitri A, Guillaumet G, Delagrange P, Friedlander RM, Vilardaga JP, Suzenet F, Jockers R. Gbahou F, et al. Br J Pharmacol. 2017 Jul;174(14):2409-2421. doi: 10.1111/bph.13856. Epub 2017 Jun 11. Br J Pharmacol. 2017. PMID: 28493341 Free PMC article.
ICOA-13 showed differential activities on melatonin receptors ranging from partial to full agonistic properties for the G(i) /cAMP and ERK pathway and β-arrestin 2 recruitment. Notably, ICOA-13 enabled us to discriminate between G(i) /cAMP signalling of the MT(1) re …
ICOA-13 showed differential activities on melatonin receptors ranging from partial to full agonistic properties for the G(i) /cAMP an …
Ranolazine in the treatment of atrial fibrillation: Results of the dose-ranging RAFFAELLO (Ranolazine in Atrial Fibrillation Following An ELectricaL CardiOversion) study.
De Ferrari GM, Maier LS, Mont L, Schwartz PJ, Simonis G, Leschke M, Gronda E, Boriani G, Darius H, Guillamón Torán L, Savelieva I, Dusi V, Marchionni N, Quintana Rendón M, Schumacher K, Tonini G, Melani L, Giannelli S, Alberto Maggi C, Camm AJ; RAFFAELLO Investigators (see Online Supplementary Appendix for List of Participating Centers and Investigators). De Ferrari GM, et al. Heart Rhythm. 2015 May;12(5):872-8. doi: 10.1016/j.hrthm.2015.01.021. Epub 2015 Jan 17. Heart Rhythm. 2015. PMID: 25602175 Clinical Trial.
New selective ligands of human cloned melatonin MT1 and MT2 receptors.
Audinot V, Mailliet F, Lahaye-Brasseur C, Bonnaud A, Le Gall A, Amossé C, Dromaint S, Rodriguez M, Nagel N, Galizzi JP, Malpaux B, Guillaumet G, Lesieur D, Lefoulon F, Renard P, Delagrange P, Boutin JA. Audinot V, et al. Naunyn Schmiedebergs Arch Pharmacol. 2003 Jun;367(6):553-61. doi: 10.1007/s00210-003-0751-2. Epub 2003 May 23. Naunyn Schmiedebergs Arch Pharmacol. 2003. PMID: 12764576
Melatonin exerts its multiple roles mainly through two seven transmembrane domain, G-coupled receptors, namely MT1 or MT2 receptors. ...
Melatonin exerts its multiple roles mainly through two seven transmembrane domain, G-coupled receptors, namely MT1 or MT2 receptors. …
Climate-driven diversification in two widespread Galerida larks.
Guillaumet A, Crochet PA, Pons JM. Guillaumet A, et al. BMC Evol Biol. 2008 Jan 29;8:32. doi: 10.1186/1471-2148-8-32. BMC Evol Biol. 2008. PMID: 18230151 Free PMC article.
Subsequent glacial cycles of the last million years seem to have shaped patterns of genetic variation within the two widespread species (G. cristata and G. theklae). ...
Subsequent glacial cycles of the last million years seem to have shaped patterns of genetic variation within the two widespread species ( …
Characterization of the melatoninergic MT3 binding site on the NRH:quinone oxidoreductase 2 enzyme.
Mailliet F, Ferry G, Vella F, Berger S, Cogé F, Chomarat P, Mallet C, Guénin SP, Guillaumet G, Viaud-Massuard MC, Yous S, Delagrange P, Boutin JA. Mailliet F, et al. Biochem Pharmacol. 2005 Dec 19;71(1-2):74-88. doi: 10.1016/j.bcp.2005.09.030. Epub 2005 Nov 15. Biochem Pharmacol. 2005. PMID: 16293234
Melatonin acts through a series of molecular targets: the G-protein coupled receptors, MT1 and MT2, and a third binding site, MT3, recently identified as the enzyme NRH:quinone oxydoreductase 2 (QR2). ...
Melatonin acts through a series of molecular targets: the G-protein coupled receptors, MT1 and MT2, and a third binding site, MT3, re …
Multilocus phylogeny of the avian family Alaudidae (larks) reveals complex morphological evolution, non-monophyletic genera and hidden species diversity.
Alström P, Barnes KN, Olsson U, Barker FK, Bloomer P, Khan AA, Qureshi MA, Guillaumet A, Crochet PA, Ryan PG. Alström P, et al. Mol Phylogenet Evol. 2013 Dec;69(3):1043-56. doi: 10.1016/j.ympev.2013.06.005. Epub 2013 Jun 21. Mol Phylogenet Evol. 2013. PMID: 23792153
The tree based on the extended mitochondrial data set revealed several unexpected deep divergences between taxa presently treated as conspecific (e.g. within Ammomanes cinctura, Ammomanes deserti, Calandrella brachydactyla, Eremophila alpestris), as well as some shallow sp …
The tree based on the extended mitochondrial data set revealed several unexpected deep divergences between taxa presently treated as conspec …
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