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Year Number of Results
1975 2
1976 1
1977 2
1981 1
1983 1
1986 1
1989 1
1992 1
1993 1
1994 2
1995 1
1996 2
1997 3
1998 5
1999 1
2000 4
2001 3
2002 5
2003 7
2004 7
2005 3
2006 3
2007 1
2008 2
2009 3
2010 4
2011 4
2012 3
2013 3
2014 4
2015 3
2016 4
2017 3
2018 6
2019 5
2020 2
2021 7
2022 8
2023 8
2024 9

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128 results

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Page 1
Base editing of haematopoietic stem cells rescues sickle cell disease in mice.
Newby GA, Yen JS, Woodard KJ, Mayuranathan T, Lazzarotto CR, Li Y, Sheppard-Tillman H, Porter SN, Yao Y, Mayberry K, Everette KA, Jang Y, Podracky CJ, Thaman E, Lechauve C, Sharma A, Henderson JM, Richter MF, Zhao KT, Miller SM, Wang T, Koblan LW, McCaffrey AP, Tisdale JF, Kalfa TA, Pruett-Miller SM, Tsai SQ, Weiss MJ, Liu DR. Newby GA, et al. Nature. 2021 Jul;595(7866):295-302. doi: 10.1038/s41586-021-03609-w. Epub 2021 Jun 2. Nature. 2021. PMID: 34079130 Free PMC article.
We used a custom adenine base editor (ABE8e-NRCH)(2,3) to convert the SCD allele (HBB(S)) into Makassar beta-globin (HBB(G)), a non-pathogenic variant(4,5). Ex vivo delivery of mRNA encoding the base editor with a targeting guide RNA into haematopoietic stem and pro …
We used a custom adenine base editor (ABE8e-NRCH)(2,3) to convert the SCD allele (HBB(S)) into Makassar beta-globin (HBB(G)), a
Na+/H+ antiporters.
Krulwich TA. Krulwich TA. Biochim Biophys Acta. 1983 Dec 30;726(4):245-64. doi: 10.1016/0304-4173(83)90011-3. Biochim Biophys Acta. 1983. PMID: 6320869 Review.
Na+/H+ antiports or exchange reactions have been found widely, if not ubiquitously, in prokaryotic and eukaryotic membranes. In any given experimental system, the multiplicity of ion conductance pathways and the absence of specific inhibitors complicate efforts to establis …
Na+/H+ antiports or exchange reactions have been found widely, if not ubiquitously, in prokaryotic and eukaryotic membranes. In any given ex …
Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability.
King AJ, Siegel M, He Y, Nie B, Wang J, Koo-McCoy S, Minassian NA, Jafri Q, Pan D, Kohler J, Kumaraswamy P, Kozuka K, Lewis JG, Dragoli D, Rosenbaum DP, O'Neill D, Plain A, Greasley PJ, Jönsson-Rylander AC, Karlsson D, Behrendt M, Strömstedt M, Ryden-Bergsten T, Knöpfel T, Pastor Arroyo EM, Hernando N, Marks J, Donowitz M, Wagner CA, Alexander RT, Caldwell JS. King AJ, et al. Sci Transl Med. 2018 Aug 29;10(456):eaam6474. doi: 10.1126/scitranslmed.aam6474. Sci Transl Med. 2018. PMID: 30158152 Free PMC article. Clinical Trial.
We investigated the mechanism by which tenapanor reduces gastrointestinal phosphate uptake, using in vivo studies in rodents and translational experiments on human small intestinal stem cell-derived enteroid monolayers to model ion transport physiology. We found tha …
We investigated the mechanism by which tenapanor reduces gastrointestinal phosphate uptake, using in vivo studies in rodents and translation …
Noninvasive Ventilation for Preoxygenation during Emergency Intubation.
Gibbs KW, Semler MW, Driver BE, Seitz KP, Stempek SB, Taylor C, Resnick-Ault D, White HD, Gandotra S, Doerschug KC, Mohamed A, Prekker ME, Khan A, Gaillard JP, Andrea L, Aggarwal NR, Brainard JC, Barnett LH, Halliday SJ, Blinder V, Dagan A, Whitson MR, Schauer SG, Walker JE Jr, Barker AB, Palakshappa JA, Muhs A, Wozniak JM, Kramer PJ, Withers C, Ghamande SA, Russell DW, Schwartz A, Moskowitz A, Hansen SJ, Allada G, Goranson JK, Fein DG, Sottile PD, Kelly N, Alwood SM, Long MT, Malhotra R, Shapiro NI, Page DB, Long BJ, Thomas CB, Trent SA, Janz DR, Rice TW, Self WH, Bebarta VS, Lloyd BD, Rhoads J, Womack K, Imhoff B, Ginde AA, Casey JD; PREOXI Investigators and the Pragmatic Critical Care Research Group. Gibbs KW, et al. N Engl J Med. 2024 Jun 20;390(23):2165-2177. doi: 10.1056/NEJMoa2313680. Epub 2024 Jun 13. N Engl J Med. 2024. PMID: 38869091 Clinical Trial.
Efficacy and Safety of NVX-CoV2373 in Adults in the United States and Mexico.
Dunkle LM, Kotloff KL, Gay CL, Áñez G, Adelglass JM, Barrat Hernández AQ, Harper WL, Duncanson DM, McArthur MA, Florescu DF, McClelland RS, Garcia-Fragoso V, Riesenberg RA, Musante DB, Fried DL, Safirstein BE, McKenzie M, Jeanfreau RJ, Kingsley JK, Henderson JA, Lane DC, Ruíz-Palacios GM, Corey L, Neuzil KM, Coombs RW, Greninger AL, Hutter J, Ake JA, Smith K, Woo W, Cho I, Glenn GM, Dubovsky F; 2019nCoV-301 Study Group. Dunkle LM, et al. N Engl J Med. 2022 Feb 10;386(6):531-543. doi: 10.1056/NEJMoa2116185. Epub 2021 Dec 15. N Engl J Med. 2022. PMID: 34910859 Free PMC article. Clinical Trial.
Clinical Features, Neuropathology, and Surgical Outcome in Patients With Refractory Epilepsy and Brain Somatic Variants in the SLC35A2 Gene.
Barba C, Blumcke I, Winawer MR, Hartlieb T, Kang HC, Grisotto L, Chipaux M, Bien CG, Heřmanovská B, Porter BE, Lidov HGW, Cetica V, Woermann FG, Lopez-Rivera JA, Canoll PD, Mader I, D'Incerti L, Baldassari S, Yang E, Gaballa A, Vogel H, Straka B, Macconi L, Polster T, Grant GA, Krsková L, Shin HJ, Ko A, Crino PB, Krsek P, Lee JH, Lal D, Baulac S, Poduri A, Guerrini R; SLC35A2 Study Group. Barba C, et al. Neurology. 2023 Jan 31;100(5):e528-e542. doi: 10.1212/WNL.0000000000201471. Epub 2022 Oct 28. Neurology. 2023. PMID: 36307217 Free PMC article.
Effect of Empagliflozin on Heart Failure Outcomes After Acute Myocardial Infarction: Insights From the EMPACT-MI Trial.
Hernandez AF, Udell JA, Jones WS, Anker SD, Petrie MC, Harrington J, Mattheus M, Seide S, Zwiener I, Amir O, Bahit MC, Bauersachs J, Bayes-Genis A, Chen Y, Chopra VK, A Figtree G, Ge J, G Goodman S, Gotcheva N, Goto S, Gasior T, Jamal W, Januzzi JL, Jeong MH, Lopatin Y, Lopes RD, Merkely B, Parikh PB, Parkhomenko A, Ponikowski P, Rossello X, Schou M, Simic D, Steg PG, Szachniewicz J, van der Meer P, Vinereanu D, Zieroth S, Brueckmann M, Sumin M, Bhatt DL, Butler J. Hernandez AF, et al. Circulation. 2024 May 21;149(21):1627-1638. doi: 10.1161/CIRCULATIONAHA.124.069217. Epub 2024 Apr 6. Circulation. 2024. PMID: 38581389 Free PMC article. Clinical Trial.
Calcium in the Backstage of Malaria Parasite Biology.
de Oliveira LS, Alborghetti MR, Carneiro RG, Bastos IMD, Amino R, Grellier P, Charneau S. de Oliveira LS, et al. Front Cell Infect Microbiol. 2021 Jul 28;11:708834. doi: 10.3389/fcimb.2021.708834. eCollection 2021. Front Cell Infect Microbiol. 2021. PMID: 34395314 Free PMC article. Review.
The calcium ion (Ca(2+)) is a ubiquitous second messenger involved in key biological processes in prokaryotes and eukaryotes. ...It is also proposed that a cross-talk among kinases, which are not members of the family of Ca(2+)-dependent protein kinases, such as protein ki …
The calcium ion (Ca(2+)) is a ubiquitous second messenger involved in key biological processes in prokaryotes and eukaryotes. ...It i …
A neuron-specific microexon ablates the novel DNA-binding function of a histone H3K4me0 reader PHF21A.
Porter RS, Nagai M, An S, Gavilan MC, Murata-Nakamura Y, Bonefas KM, Zhou B, Dionne O, Manuel JM, St-Germain J, Browning L, Laurent B, Cho US, Iwase S. Porter RS, et al. bioRxiv [Preprint]. 2023 Oct 21:2023.10.20.563357. doi: 10.1101/2023.10.20.563357. bioRxiv. 2023. PMID: 37904995 Free PMC article. Preprint.
Furthermore, an autism-associated PHF21A missense mutation, 1285 G>A, at the last nucleotide of the common exon immediately upstream of the neuronal microexon led to impaired splicing of PHF21A -n. ...
Furthermore, an autism-associated PHF21A missense mutation, 1285 G>A, at the last nucleotide of the common exon immediately …
Steroid-based anion receptors and transporters.
Brotherhood PR, Davis AP. Brotherhood PR, et al. Chem Soc Rev. 2010 Oct;39(10):3633-47. doi: 10.1039/b926225n. Epub 2010 Aug 11. Chem Soc Rev. 2010. PMID: 20714471 Review.
Anion binding and transport are important goals of supramolecular chemistry, especially in light of the potential for biological activity. Success depends on scaffolds which can preorganise polar functionality for anion recognition, and can maintain the right physical prop …
Anion binding and transport are important goals of supramolecular chemistry, especially in light of the potential for biological acti …
128 results