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Year Number of Results
2013 3
2014 3
2015 2
2016 1
2017 1
2018 1
2019 2
2020 8
2021 5
2022 4
2023 7

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32 results

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Page 1
Enhancing clinical and immunological effects of anti-PD-1 with belapectin, a galectin-3 inhibitor.
Curti BD, Koguchi Y, Leidner RS, Rolig AS, Sturgill ER, Sun Z, Wu Y, Rajamanickam V, Bernard B, Hilgart-Martiszus I, Fountain CB, Morris G, Iwamoto N, Shimada T, Chang S, Traber PG, Zomer E, Horton JR, Shlevin H, Redmond WL. Curti BD, et al. J Immunother Cancer. 2021 Apr;9(4):e002371. doi: 10.1136/jitc-2021-002371. J Immunother Cancer. 2021. PMID: 33837055 Free PMC article. Clinical Trial.
BACKGROUND: PD-1/PD-L1 engagement and overexpression of galectin-3 (Gal-3) are critical mechanisms of tumor-induced immune suppression that contribute to immunotherapy resistance. ...CONCLUSIONS: Belapectin+pembrolizumab therapy has activity in MM and HNSCC. Increased G …
BACKGROUND: PD-1/PD-L1 engagement and overexpression of galectin-3 (Gal-3) are critical mechanisms of tumor-induced immune suppressio …
Examining the Acute Glycemic Effects of Different Types of Structured Exercise Sessions in Type 1 Diabetes in a Real-World Setting: The Type 1 Diabetes and Exercise Initiative (T1DEXI).
Riddell MC, Li Z, Gal RL, Calhoun P, Jacobs PG, Clements MA, Martin CK, Doyle Iii FJ, Patton SR, Castle JR, Gillingham MB, Beck RW, Rickels MR; T1DEXI Study Group. Riddell MC, et al. Diabetes Care. 2023 Apr 1;46(4):704-713. doi: 10.2337/dc22-1721. Diabetes Care. 2023. PMID: 36795053 Free PMC article. Clinical Trial.
Galectin-3 is Associated with Heart Failure Incidence: A Meta-Analysis.
Baccouche BM, Mahmoud MA, Nief C, Patel K, Natterson-Horowitz B. Baccouche BM, et al. Curr Cardiol Rev. 2023;19(3):e171122211004. doi: 10.2174/1573403X19666221117122012. Curr Cardiol Rev. 2023. PMID: 36397629 Review.
RESULTS: The minimally-adjusted model provided an HR of 1.97 (95% CI 1.74-2.23) when comparing the top quartile of log-gal-3 to the bottom quartile. The further-adjusted model provided an HR of 1.32 (95% CI 1.21-1.44) for the same comparison. ...
RESULTS: The minimally-adjusted model provided an HR of 1.97 (95% CI 1.74-2.23) when comparing the top quartile of log-gal-3 to the b …
Expanding the Phenotypic Spectrum of Kenny-Caffey Syndrome.
Schigt H, Bald M, van der Eerden BCJ, Gal L, Ilenwabor BP, Konrad M, Levine MA, Li D, Mache CJ, Mackin S, Perry C, Rios FJ, Schlingmann KP, Storey B, Trapp CM, Verkerk AJMH, Zillikens MC, Touyz RM, Hoorn EJ, Hoenderop JGJ, de Baaij JHF. Schigt H, et al. J Clin Endocrinol Metab. 2023 Aug 18;108(9):e754-e768. doi: 10.1210/clinem/dgad147. J Clin Endocrinol Metab. 2023. PMID: 36916904 Free PMC article.
Galectin-1 and immune suppression during radiotherapy.
Welsh JW, Seyedin SN, Cortez MA, Maity A, Hahn SM. Welsh JW, et al. Clin Cancer Res. 2014 Dec 15;20(24):6230-2. doi: 10.1158/1078-0432.CCR-14-2702. Epub 2014 Oct 27. Clin Cancer Res. 2014. PMID: 25348514
Radiotherapy induces galectin-1 (Gal-1) secretion by tumors, which induces CD8(+) T-cell apoptosis and lymphopenia. These effects are substantially decreased by Gal-1 shRNA. Inhibition of Gal-1 may be an effective strategy for overcoming radiation-induced lym …
Radiotherapy induces galectin-1 (Gal-1) secretion by tumors, which induces CD8(+) T-cell apoptosis and lymphopenia. These effects are …
RNA-seq analysis of galaninergic neurons from ventrolateral preoptic nucleus identifies expression changes between sleep and wake.
Guo X, Gao X, Keenan BT, Zhu J, Sarantopoulou D, Lian J, Galante RJ, Grant GR, Pack AI. Guo X, et al. BMC Genomics. 2020 Sep 14;21(1):633. doi: 10.1186/s12864-020-07050-7. BMC Genomics. 2020. PMID: 32928100 Free PMC article.
BACKGROUND: Previous studies show that galanin neurons in ventrolateral preoptic nucleus (VLPO-Gal) are essential for sleep regulation. Here, we explored the transcriptional regulation of the VLPO-Gal neurons in sleep by comparing their transcriptional responses bet …
BACKGROUND: Previous studies show that galanin neurons in ventrolateral preoptic nucleus (VLPO-Gal) are essential for sleep regulatio …
Evaluation of galectin-3 and intestinal fatty acid binding protein as serum biomarkers in autosomal recessive polycystic kidney disease.
Fleischer LT, Ballester L, Dutt M, Howarth K, Poznick L, Darge K, Furth SL, Hartung EA. Fleischer LT, et al. J Nephrol. 2023 Jan;36(1):133-145. doi: 10.1007/s40620-022-01416-8. Epub 2022 Aug 18. J Nephrol. 2023. PMID: 35980535

Serum Gal-3 and I-FABP were analyzed using enzyme linked immunosorbent assay. ...RESULTS: Serum Gal-3 was negatively associated with eGFR; 1 standard deviation (SD) lower eGFR was associated with 0.795 SD higher Gal-3 level (95% CI - 1.116, - 0.473; p < 0.

…
Serum Gal-3 and I-FABP were analyzed using enzyme linked immunosorbent assay. ...RESULTS: Serum Gal-3 was negatively associate …
Withdrawn as duplicate: Expanding the phenotypic spectrum of Kenny-Caffey syndrome: a case series and systematic literature review.
Schigt H, Bald M, van der Eerden BCJ, Gal L, Ilenwabor BP, Konrad M, Levine MA, Li D, Mache CJ, Mackin S, Perry C, Rios FJ, Schlingmann KP, Storey B, Trapp CM, Verkerk AJMH, Zillikens MC, Touyz RM, Hoorn EJ, Hoenderop JGJ, de Baaij JHF. Schigt H, et al. J Clin Endocrinol Metab. 2023 Jun 16;108(7):e501. doi: 10.1210/clinem/dgad154. J Clin Endocrinol Metab. 2023. PMID: 36919775
A Single Injection of an Optimized Adeno-Associated Viral Vector into Cerebrospinal Fluid Corrects Neurological Disease in a Murine Model of GM1 Gangliosidosis.
Hinderer C, Nosratbakhsh B, Katz N, Wilson JM. Hinderer C, et al. Hum Gene Ther. 2020 Nov;31(21-22):1169-1177. doi: 10.1089/hum.2018.206. Epub 2020 Nov 2. Hum Gene Ther. 2020. PMID: 33045869 Free PMC article.
GM1 gangliosidosis is a rare neurodegenerative lysosomal storage disease caused by loss-of-function mutations in the gene encoding beta-galactosidase (beta-gal). There are no approved treatments for GM1 gangliosidosis. Previous studies in animal models have demonstrated th …
GM1 gangliosidosis is a rare neurodegenerative lysosomal storage disease caused by loss-of-function mutations in the gene encoding beta-gala …
32 results