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Year Number of Results
2013 3
2014 3
2015 2
2016 1
2017 1
2018 1
2019 2
2020 8
2021 5
2022 1
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23 results
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Enhancing clinical and immunological effects of anti-PD-1 with belapectin, a galectin-3 inhibitor.
Curti BD, Koguchi Y, Leidner RS, Rolig AS, Sturgill ER, Sun Z, Wu Y, Rajamanickam V, Bernard B, Hilgart-Martiszus I, Fountain CB, Morris G, Iwamoto N, Shimada T, Chang S, Traber PG, Zomer E, Horton JR, Shlevin H, Redmond WL. Curti BD, et al. J Immunother Cancer. 2021 Apr;9(4):e002371. doi: 10.1136/jitc-2021-002371. J Immunother Cancer. 2021. PMID: 33837055 Free PMC article. Clinical Trial.
BACKGROUND: PD-1/PD-L1 engagement and overexpression of galectin-3 (Gal-3) are critical mechanisms of tumor-induced immune suppression that contribute to immunotherapy resistance. ...CONCLUSIONS: Belapectin+pembrolizumab therapy has activity in MM and HNSCC. Increased G
BACKGROUND: PD-1/PD-L1 engagement and overexpression of galectin-3 (Gal-3) are critical mechanisms of tumor-induced immune suppressio …
Ultrasound evaluation of varicoceles: guidelines and recommendations of the European Society of Urogenital Radiology Scrotal and Penile Imaging Working Group (ESUR-SPIWG) for detection, classification, and grading.
Freeman S, Bertolotto M, Richenberg J, Belfield J, Dogra V, Huang DY, Lotti F, Markiet K, Nikolic O, Ramanathan S, Ramchandani P, Rocher L, Secil M, Sidhu PS, Skrobisz K, Studniarek M, Tsili A, Tuncay Turgut A, Pavlica P, Derchi LE; members of the ESUR-SPIWG WG. Freeman S, et al. Eur Radiol. 2020 Jan;30(1):11-25. doi: 10.1007/s00330-019-06280-y. Epub 2019 Jul 22. Eur Radiol. 2020. PMID: 31332561
Racial-Ethnic Inequity in Young Adults With Type 1 Diabetes.
Agarwal S, Kanapka LG, Raymond JK, Walker A, Gerard-Gonzalez A, Kruger D, Redondo MJ, Rickels MR, Shah VN, Butler A, Gonzalez J, Verdejo AS, Gal RL, Willi S, Long JA. Agarwal S, et al. J Clin Endocrinol Metab. 2020 Aug 1;105(8):e2960-9. doi: 10.1210/clinem/dgaa236. J Clin Endocrinol Metab. 2020. PMID: 32382736 Free PMC article.
RNA-seq analysis of galaninergic neurons from ventrolateral preoptic nucleus identifies expression changes between sleep and wake.
Guo X, Gao X, Keenan BT, Zhu J, Sarantopoulou D, Lian J, Galante RJ, Grant GR, Pack AI. Guo X, et al. BMC Genomics. 2020 Sep 14;21(1):633. doi: 10.1186/s12864-020-07050-7. BMC Genomics. 2020. PMID: 32928100 Free PMC article.
BACKGROUND: Previous studies show that galanin neurons in ventrolateral preoptic nucleus (VLPO-Gal) are essential for sleep regulation. Here, we explored the transcriptional regulation of the VLPO-Gal neurons in sleep by comparing their transcriptional responses bet …
BACKGROUND: Previous studies show that galanin neurons in ventrolateral preoptic nucleus (VLPO-Gal) are essential for sleep regulatio …
Galectin-1 and immune suppression during radiotherapy.
Welsh JW, Seyedin SN, Cortez MA, Maity A, Hahn SM. Welsh JW, et al. Clin Cancer Res. 2014 Dec 15;20(24):6230-2. doi: 10.1158/1078-0432.CCR-14-2702. Epub 2014 Oct 27. Clin Cancer Res. 2014. PMID: 25348514
Radiotherapy induces galectin-1 (Gal-1) secretion by tumors, which induces CD8(+) T-cell apoptosis and lymphopenia. These effects are substantially decreased by Gal-1 shRNA. Inhibition of Gal-1 may be an effective strategy for overcoming radiation-induced lym …
Radiotherapy induces galectin-1 (Gal-1) secretion by tumors, which induces CD8(+) T-cell apoptosis and lymphopenia. These effects are …
A Single Injection of an Optimized Adeno-Associated Viral Vector into Cerebrospinal Fluid Corrects Neurological Disease in a Murine Model of GM1 Gangliosidosis.
Hinderer C, Nosratbakhsh B, Katz N, Wilson JM. Hinderer C, et al. Hum Gene Ther. 2020 Nov;31(21-22):1169-1177. doi: 10.1089/hum.2018.206. Epub 2020 Nov 2. Hum Gene Ther. 2020. PMID: 33045869 Free PMC article.
GM1 gangliosidosis is a rare neurodegenerative lysosomal storage disease caused by loss-of-function mutations in the gene encoding beta-galactosidase (beta-gal). There are no approved treatments for GM1 gangliosidosis. Previous studies in animal models have demonstrated th …
GM1 gangliosidosis is a rare neurodegenerative lysosomal storage disease caused by loss-of-function mutations in the gene encoding beta-gala …
Ultrasound evaluation of varicoceles: systematic literature review and rationale of the ESUR-SPIWG Guidelines and Recommendations.
Bertolotto M, Freeman S, Richenberg J, Belfield J, Dogra V, Huang DY, Lotti F, Markiet K, Nikolic O, Ramanathan S, Ramchandani P, Rocher L, Secil M, Sidhu PS, Skrobisz K, Studniarek M, Tsili A, Turgut AT, Pavlica P, Derchi LE; Members of the ESUR-SPIWG WG. Bertolotto M, et al. J Ultrasound. 2020 Dec;23(4):487-507. doi: 10.1007/s40477-020-00509-z. Epub 2020 Jul 27. J Ultrasound. 2020. PMID: 32720266 Free PMC article.
23 results