Bromopyrrole Alkaloid Inhibitors of the Proteasome Isolated from a Dictyonella sp. Marine Sponge Collected at the Amazon River Mouth.
de Souza RTMP, Freire VF, Gubiani JR, Ferreira RO, Trivella DBB, Moraes FC, Paradas WC, Salgado LT, Pereira RC, Amado Filho GM, Ferreira AG, Williams DE, Andersen RJ, Molinski TF, Berlinck RGS.
de Souza RTMP, et al.
J Nat Prod. 2018 Oct 26;81(10):2296-2300. doi: 10.1021/acs.jnatprod.8b00533. Epub 2018 Oct 3.
J Nat Prod. 2018.
PMID: 30281303
The bromine-substitution pattern observed for compounds 1, 2 and 4 is unusual among bromopyrrole alkaloids isolated from marine sponges. The 20S proteasome inhibitory activities of compounds 1-6 have been recorded, with 5-bromopalau'amine (4) being the most active in this …
The bromine-substitution pattern observed for compounds 1, 2 and 4 is unusual among bromopyrrole alkaloids isolated from marine sponges. The …