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The following terms were not found in PubMed: 20Oliveira
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Structural elucidation of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors.
Silhan J, Fajtova P, Bartosova J, Hurysz BM, Almaliti J, Miyamoto Y, Eckmann L, Gerwick WH, O'Donoghue AJ, Boura E. Silhan J, et al. bioRxiv [Preprint]. 2023 Aug 17:2023.08.17.553660. doi: 10.1101/2023.08.17.553660. bioRxiv. 2023. PMID: 37645851 Free PMC article. Preprint.
Proteasomes are essential for protein homeostasis in mammalian cells(1-4) and in protozoan parasites such as Trichomonas vaginalis (Tv).(5) Tv and other protozoan 20S proteasomes have been validated as druggable targets.(6-8) However, in the case of Tv 20S proteasom …
Proteasomes are essential for protein homeostasis in mammalian cells(1-4) and in protozoan parasites such as Trichomonas vaginalis (Tv).(5) …
Development of subunit selective proteasome substrates for Schistosoma species.
Jiang Z, Silva EB, Liu C, Fajtová P, Liu LJ, El-Sakkary N, Skinner DE, Syed A, Wang SC, Caffrey CR, O'Donoghue AJ. Jiang Z, et al. bioRxiv [Preprint]. 2024 Feb 14:2024.02.13.580161. doi: 10.1101/2024.02.13.580161. bioRxiv. 2024. PMID: 38405969 Free PMC article. Preprint.
Just one partially effective drug is available, and new drugs and drug targets would be welcome. The 20S proteasome is a validated drug target for many parasitic infections, including those caused by Plasmodium and Leishmania. ...Finally, we show that the substrate and inh …
Just one partially effective drug is available, and new drugs and drug targets would be welcome. The 20S proteasome is a validated dr …
Bromopyrrole Alkaloid Inhibitors of the Proteasome Isolated from a Dictyonella sp. Marine Sponge Collected at the Amazon River Mouth.
de Souza RTMP, Freire VF, Gubiani JR, Ferreira RO, Trivella DBB, Moraes FC, Paradas WC, Salgado LT, Pereira RC, Amado Filho GM, Ferreira AG, Williams DE, Andersen RJ, Molinski TF, Berlinck RGS. de Souza RTMP, et al. J Nat Prod. 2018 Oct 26;81(10):2296-2300. doi: 10.1021/acs.jnatprod.8b00533. Epub 2018 Oct 3. J Nat Prod. 2018. PMID: 30281303
The bromine-substitution pattern observed for compounds 1, 2 and 4 is unusual among bromopyrrole alkaloids isolated from marine sponges. The 20S proteasome inhibitory activities of compounds 1-6 have been recorded, with 5-bromopalau'amine (4) being the most active in this …
The bromine-substitution pattern observed for compounds 1, 2 and 4 is unusual among bromopyrrole alkaloids isolated from marine sponges. The …
Amyloid-beta peptide is a substrate of the human 20S proteasome.
Zhao X, Yang J. Zhao X, et al. ACS Chem Neurosci. 2010 Oct 20;1(10):655-660. doi: 10.1021/cn100067e. ACS Chem Neurosci. 2010. PMID: 21116456 Free PMC article.
Here, we provide additional insight into proteasomal dysfunction by Abeta peptides by revealing that aggregated forms of Abeta(1-42) peptides (especially small oligomers) are, in fact, competitive substrates for the chymotrypsin-like activity of the human 20S (h20S) protea …
Here, we provide additional insight into proteasomal dysfunction by Abeta peptides by revealing that aggregated forms of Abeta(1-42) peptide …
Predictors of Loneliness by Age Decade: Study of Psychological and Environmental Factors in 2,843 Community-Dwelling Americans Aged 20-69 Years.
Nguyen TT, Lee EE, Daly RE, Wu TC, Tang Y, Tu X, Van Patten R, Jeste DV, Palmer BW. Nguyen TT, et al. J Clin Psychiatry. 2020 Nov 10;81(6):20m13378. doi: 10.4088/JCP.20m13378. J Clin Psychiatry. 2020. PMID: 33176072 Free PMC article.
RESULTS: Age demonstrated a nonlinear quadratic relationship with loneliness (Wald statistic = 5.48, P = .019); levels were highest in the 20s and lowest in the 60s with another peak in the mid-40s. Across all decades, loneliness was associated with not having a spouse or …
RESULTS: Age demonstrated a nonlinear quadratic relationship with loneliness (Wald statistic = 5.48, P = .019); levels were highest in the …
Development of a canine nociceptive thermal escape model.
Wegner K, Horais KA, Tozier NA, Rathbun ML, Shtaerman Y, Yaksh TL. Wegner K, et al. J Neurosci Methods. 2008 Feb 15;168(1):88-97. doi: 10.1016/j.jneumeth.2007.09.019. Epub 2007 Sep 29. J Neurosci Methods. 2008. PMID: 18054083 Free PMC article. Clinical Trial.
This latency corresponded to a glass surface temperature of 49.5 degrees C. A cut-off time of 20s (corresponding to a glass surface temperature of 56.5 degrees C) was set to prevent tissue damage. ...
This latency corresponded to a glass surface temperature of 49.5 degrees C. A cut-off time of 20s (corresponding to a glass surface t …
C-SPACE (cleavage-specific amplification of cDNA ends): a novel method of ribozyme-mediated gene identification.
Krüger M, Beger C, Welch PJ, Barber JR, Wong-Staal F. Krüger M, et al. Nucleic Acids Res. 2001 Oct 1;29(19):E94. doi: 10.1093/nar/29.19.e94. Nucleic Acids Res. 2001. PMID: 11574696 Free PMC article.
In a similar approach, C-SPACE was used successfully to identify human 20S proteasome alpha-subunit PSMA7 mRNA as the cellular target RNA of Rz3'X, a ribozyme originally designed to cleave the negative strand HCV 3'-UTR. ...
In a similar approach, C-SPACE was used successfully to identify human 20S proteasome alpha-subunit PSMA7 mRNA as the cellular target …
Involvement of proteasome alpha-subunit PSMA7 in hepatitis C virus internal ribosome entry site-mediated translation.
Krüger M, Beger C, Welch PJ, Barber JR, Manns MP, Wong-Staal F. Krüger M, et al. Mol Cell Biol. 2001 Dec;21(24):8357-64. doi: 10.1128/MCB.21.24.8357-8364.2001. Mol Cell Biol. 2001. PMID: 11713272 Free PMC article.
Wong-Staal, Nucleic Acids Res. 29:e94, 2001) revealed that human 20S proteasome alpha-subunit PSMA7 mRNA was a target RNA recognized and cleaved by Rz3'X. ...
Wong-Staal, Nucleic Acids Res. 29:e94, 2001) revealed that human 20S proteasome alpha-subunit PSMA7 mRNA was a target RNA recognized …
Cardenolide analogues. 2. 22-Methylenecard-14-enolides.
Fullerton DS, Gilman TM, Pankaskie MC, Ahmed K, From AH, Duax WL, Rohrer DC. Fullerton DS, et al. J Med Chem. 1977 Jun;20(6):841-4. doi: 10.1021/jm00216a022. J Med Chem. 1977. PMID: 141522