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Glucocorticoid receptor isoform-specific regulation of development, circadian rhythm, and inflammation in mice.
Oakley RH, Ramamoorthy S, Foley JF, Busada JT, Lu NZ, Cidlowski JA. Oakley RH, et al. FASEB J. 2018 Oct;32(10):5258-5271. doi: 10.1096/fj.201701153R. Epub 2018 Apr 19. FASEB J. 2018. PMID: 29672221 Free PMC article.
We have generated knockin mice that exclusively express the most active receptor isoform, GR-C3. GR-C3 knockin mice die at birth due to respiratory distress. Microarray analysis of fibroblasts from wild-type and GR-C3 mice indicated that …
We have generated knockin mice that exclusively express the most active receptor isoform, GR-C3. GR-C3 knockin m …
Determinants of the heightened activity of glucocorticoid receptor translational isoforms.
Bender IK, Cao Y, Lu NZ. Bender IK, et al. Mol Endocrinol. 2013 Sep;27(9):1577-87. doi: 10.1210/me.2013-1009. Epub 2013 Jul 2. Mol Endocrinol. 2013. PMID: 23820903 Free PMC article.
Whereas a lack of activation function 1 (AF1) may underlie the reduced activity of the GR-D isoforms, it is not clear how the GR-C3 isoform has heightened activity. Mutation analyses and N-terminal tagging demonstrated that steric hindrance is probably the mechanism …
Whereas a lack of activation function 1 (AF1) may underlie the reduced activity of the GR-D isoforms, it is not clear how the GR-C …
Selective glucocorticoid receptor translational isoforms reveal glucocorticoid-induced apoptotic transcriptomes.
Wu I, Shin SC, Cao Y, Bender IK, Jafari N, Feng G, Lin S, Cidlowski JA, Schleimer RP, Lu NZ. Wu I, et al. Cell Death Dis. 2013 Jan 10;4(1):e453. doi: 10.1038/cddis.2012.193. Cell Death Dis. 2013. PMID: 23303127 Free PMC article.
DEX induced apoptosis in cells expressing the GR-A, -B, or -C, but not the GR-D, isoform. cDNA microarray analyses of cells sensitive (GR-C3) and insensitive (GR-D3) to DEX revealed glucocorticoid-induced proapoptotic transcriptomes. Genes that were regulated by the …
DEX induced apoptosis in cells expressing the GR-A, -B, or -C, but not the GR-D, isoform. cDNA microarray analyses of cells sensitive (GR …
Imaging of glyphosate uptake and identification of early microscopic markers in leaves of C3 and C4 glyphosate-resistant and -susceptible species.
Cardoso-Gustavson P, Dias MG, Costa FOB, de Moura Leite Camargos G, da Cruz Centeno D. Cardoso-Gustavson P, et al. Ecotoxicol Environ Saf. 2018 Nov 15;163:502-513. doi: 10.1016/j.ecoenv.2018.07.096. Epub 2018 Jul 31. Ecotoxicol Environ Saf. 2018. PMID: 30075454
A specific type of cell necrosis (hypersensitive response) was observed in GR-C4 species as a way to prevent the translocation of this herbicide, while GR-C3 species accumulated phenolic compounds inside the vacuole, probably sequestrating and inactivating the glyph …
A specific type of cell necrosis (hypersensitive response) was observed in GR-C4 species as a way to prevent the translocation of this herbi …