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Showing results for hector ibarra model
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Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis.
Lim B, Kamal A, Gomez Ramos B, Adrian Segarra JM, Ibarra IL, Dignas L, Kindinger T, Volz K, Rahbari M, Rahbari N, Poisel E, Kafetzopoulou K, Böse L, Breinig M, Heide D, Gallage S, Barragan Avila JE, Wiethoff H, Berest I, Schnabellehner S, Schneider M, Becker J, Helm D, Grimm D, Mäkinen T, Tschaharganeh DF, Heikenwalder M, Zaugg JB, Mall M. Lim B, et al. Nat Genet. 2025 Mar;57(3):668-679. doi: 10.1038/s41588-025-02081-w. Epub 2025 Feb 13. Nat Genet. 2025. PMID: 39948437 Free PMC article.
Our findings provide evidence for PROX1 as a hepatocyte-specific safeguard and support a model where cell-type-specific repressors actively suppress plasticity throughout life to safeguard lineage identity and thus prevent disease....
Our findings provide evidence for PROX1 as a hepatocyte-specific safeguard and support a model where cell-type-specific repressors ac …
Serial real-time RT-PCR and serology measurements substantially improve Zika and Dengue virus infection classification in a co-circulation area.
Gouel-Cheron A, Lumbard K, Hunsberger S, Arteaga-Cabello FJ, Beigel J, Belaunzarán-Zamudio PF, Caballero-Sosa S, Escobedo-López K, Ibarra-González V, Nájera-Cancino JG, Rincón-León HA, Ruiz-Hernández E, Sepúlveda-Delgado J, Trujillo-Murillo K, Ruiz-Palacios G. Gouel-Cheron A, et al. Antiviral Res. 2019 Dec;172:104638. doi: 10.1016/j.antiviral.2019.104638. Epub 2019 Oct 28. Antiviral Res. 2019. PMID: 31672665 Free PMC article.
In the classification model, true positives were symptomatic (using a modified World Health Organization/Pan American Health Organization definition) with RT-PCR positive for ZIKV or DENV. ...When considering sensitivity and specificity together, the serial serology mod …
In the classification model, true positives were symptomatic (using a modified World Health Organization/Pan American Health Organiza …