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Page 1
Nonbiopsy Diagnosis of Cardiac Transthyretin Amyloidosis.
Gillmore JD, Maurer MS, Falk RH, Merlini G, Damy T, Dispenzieri A, Wechalekar AD, Berk JL, Quarta CC, Grogan M, Lachmann HJ, Bokhari S, Castano A, Dorbala S, Johnson GB, Glaudemans AW, Rezk T, Fontana M, Palladini G, Milani P, Guidalotti PL, Flatman K, Lane T, Vonberg FW, Whelan CJ, Moon JC, Ruberg FL, Miller EJ, Hutt DF, Hazenberg BP, Rapezzi C, Hawkins PN. Gillmore JD, et al. Circulation. 2016 Jun 14;133(24):2404-12. doi: 10.1161/CIRCULATIONAHA.116.021612. Epub 2016 Apr 22. Circulation. 2016. PMID: 27143678
Natural History, Quality of Life, and Outcome in Cardiac Transthyretin Amyloidosis.
Lane T, Fontana M, Martinez-Naharro A, Quarta CC, Whelan CJ, Petrie A, Rowczenio DM, Gilbertson JA, Hutt DF, Rezk T, Strehina SG, Caringal-Galima J, Manwani R, Sharpley FA, Wechalekar AD, Lachmann HJ, Mahmood S, Sachchithanantham S, Drage EPS, Jenner HD, McDonald R, Bertolli O, Calleja A, Hawkins PN, Gillmore JD. Lane T, et al. Circulation. 2019 Jul 2;140(1):16-26. doi: 10.1161/CIRCULATIONAHA.118.038169. Epub 2019 May 21. Circulation. 2019. PMID: 31109193
Resistant Hypertension: Trials and Tribulations.
George MJ, Marks DJB, Rezk T, Breckenridge R, Sofat R, Martin J, MacAllister R, Touyz RM, Staessen JA, Bursztyn M, Lappin D, Barigou M, Hingorani A. George MJ, et al. Hypertension. 2018 May;71(5):772-780. doi: 10.1161/HYPERTENSIONAHA.118.10864. Epub 2018 Apr 2. Hypertension. 2018. PMID: 29610269 Review. No abstract available.
Endotracheal aerosolization of atropine sulfate protects against soman-induced acute respiratory toxicity in guinea pigs.
Perkins MW, Pierre Z, Rezk P, Song J, Marshall S, Oguntayo S, Morthole V, Sciuto AM, Doctor BP, Nambiar MP. Perkins MW, et al. Inhal Toxicol. 2011 Mar;23(4):182-95. doi: 10.3109/08958378.2011.554458. Inhal Toxicol. 2011. PMID: 21456952
The efficacy of endotracheal aerosolization of atropine sulfate for protection against soman (GD)-induced respiratory toxicity was investigated using microinstillation technique in guinea pigs. GD (841 mg/m(3), 1.3 LCt(50) or 1121 mg/m(3), 1.7 LCt(50)) was aerosoliz …
The efficacy of endotracheal aerosolization of atropine sulfate for protection against soman (GD)-induced respiratory toxicity was investiga …
Acute lung injury following inhalation exposure to nerve agent VX in guinea pigs.
Wright BS, Rezk PE, Graham JR, Steele KE, Gordon RK, Sciuto AM, Nambiar MP. Wright BS, et al. Inhal Toxicol. 2006 May;18(6):437-48. doi: 10.1080/08958370600563847. Inhal Toxicol. 2006. PMID: 16556583
Trypan blue viability assay indicated an increase in BAL cell death in 70.4 microg/m(m3) and 90.4 microg/m(m3) VX-exposed animals. Differential cell counting of BALC indicated a decrease in macrophage/monocytes in VX-exposed animals. The total amount of BAL protein …
Trypan blue viability assay indicated an increase in BAL cell death in 70.4 microg/m(m3) and 90.4 microg/m(m3) VX-exposed anim …
Angiotensin II infusion induces marked diaphragmatic skeletal muscle atrophy.
Rezk BM, Yoshida T, Semprun-Prieto L, Higashi Y, Sukhanov S, Delafontaine P. Rezk BM, et al. PLoS One. 2012;7(1):e30276. doi: 10.1371/journal.pone.0030276. Epub 2012 Jan 20. PLoS One. 2012. PMID: 22276172 Free PMC article.
Expression of the E3 ubiquitin ligases atrogin-1 and muscle ring finger-1 (MuRF-1) and of the pro-apoptotic factor BAX was increased after 24 h of Ang II infusion (4.40.3 fold, 3.10.5 fold and 1.60.2 fold, respectively, compared to sham infused control) suggesting increase …
Expression of the E3 ubiquitin ligases atrogin-1 and muscle ring finger-1 (MuRF-1) and of the pro-apoptotic factor BAX was increased after 2 …
Rapid determination of canagliflozin in rat plasma by UHPLC-MS/MS using negative ionization mode to avoid adduct-ions formation.
Iqbal M, Ezzeldin E, Al-Rashood KA, Asiri YA, Rezk NL. Iqbal M, et al. Talanta. 2015 Jan;132:29-36. doi: 10.1016/j.talanta.2014.08.041. Epub 2014 Aug 23. Talanta. 2015. PMID: 25476275
Multiple reaction monitoring were used for quantitation of precursor to product ion at m/z 443.16 >364.96 for canagliflozin and m/z 574.11>462.07 for IS, respectively. ...The mean maximum plasma concentration of canagliflozin of 1616.79 ng mL(-1) was achieved …
Multiple reaction monitoring were used for quantitation of precursor to product ion at m/z 443.16 >364.96 for canagliflozin and …
Assessment of cytotoxicity exerted by leaf extracts from plants of the genus Rhododendron towards epidermal keratinocytes and intestine epithelial cells.
Rezk A, Al-Hashimi A, John W, Schepker H, Ullrich MS, Brix K. Rezk A, et al. BMC Complement Altern Med. 2015 Oct 15;15:364. doi: 10.1186/s12906-015-0860-8. BMC Complement Altern Med. 2015. PMID: 26470706 Free PMC article.
METHODS: Different concentrations of DMSO-dissolved remnants of crude methanol Rhododendron leaf extracts were incubated for 24 h with cultured epidermal keratinocytes (human HaCaT cell line) and epithelial cells of the intestinal mucosa (rat IEC6 cell line) and tested for …
METHODS: Different concentrations of DMSO-dissolved remnants of crude methanol Rhododendron leaf extracts were incubated for 24 h wit …
Treatment with endotracheal therapeutics after sarin microinstillation inhalation exposure increases blood cholinesterase levels in guinea pigs.
Che MM, Song J, Oguntayo S, Doctor BP, Rezk P, Perkins MW, Sciuto AM, Nambiar MP. Che MM, et al. Toxicol Mech Methods. 2012 May;22(4):250-9. doi: 10.3109/15376516.2011.639817. Epub 2011 Dec 7. Toxicol Mech Methods. 2012. PMID: 22145985
Therapeutics included, aerosolized atropine methyl bromide (AMB), scopolamine or combination of AMB with salbutamol, sphingosine 1-phosphate, keratinocyte growth factor, adenosine A1 receptor antisense oligonucleotide (EPI2010), 2,3-diacetyloxybenzoic acid (2,3 DABA), oxycyte, an …
Therapeutics included, aerosolized atropine methyl bromide (AMB), scopolamine or combination of AMB with salbutamol, sphingosine 1-phosphate …
CYP2B6 variants and plasma efavirenz concentrations during antiretroviral therapy in Port-au-Prince, Haiti.
Leger P, Dillingham R, Beauharnais CA, Kashuba AD, Rezk NL, Fitzgerald DW, Pape JW, Haas DW. Leger P, et al. J Infect Dis. 2009 Sep 15;200(6):955-64. doi: 10.1086/605126. J Infect Dis. 2009. PMID: 19659438 Free PMC article.
RESULTS: Plasma specimens for efavirenz analysis were obtained from study participants a mean (+/- standard deviation) of 13.9 +/- 1.6 h after they received the dose. As expected, CYP2B6 516G-->T was associated with increased plasma efavirenz concentrations (Spearman rh …
RESULTS: Plasma specimens for efavirenz analysis were obtained from study participants a mean (+/- standard deviation) of 13.9 +/- 1.6 h
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