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Page 1
Omicron BA.1 breakthrough infections in inactivated COVID-19 vaccine recipients induced distinct pattern of antibody and T cell responses to different Omicron sublineages.
Guo L, Zhang Q, Zhong J, Chen L, Jiang W, Huang T, Li Y, Zhang Y, Xu L, Wang X, Xiao Y, Wang Y, Dong X, Dong T, Peng Y, Zhang B, Xie Y, Gao H, Shen Z, Ren L, Cheng T, Wang J. Guo L, et al. Emerg Microbes Infect. 2023 Dec;12(1):2202263. doi: 10.1080/22221751.2023.2202263. Emerg Microbes Infect. 2023. PMID: 37037791 Free PMC article.
BA.1 breakthrough infection boosted antibody-dependent cellular cytotoxicity and antibody-dependent cellular phagocytosis to prototype strain and BA.1, BA.1.1, BA.2, BA.2.12.1, and BA.2.75 but not BA.4/5 and induced neutralization …
BA.1 breakthrough infection boosted antibody-dependent cellular cytotoxicity and antibody-dependent cellular phagocytosis to prototyp …
Safety and activity of an engineered, liver-tropic adeno-associated virus vector expressing a hyperactive Padua factor IX administered with prophylactic glucocorticoids in patients with haemophilia B: a single-centre, single-arm, phase 1, pilot trial.
Xue F, Li H, Wu X, Liu W, Zhang F, Tang D, Chen Y, Wang W, Chi Y, Zheng J, Du Z, Jiang W, Zhong C, Wei J, Zhu P, Fu R, Liu X, Chen L, Pei X, Sun J, Cheng T, Yang R, Xiao X, Zhang L. Xue F, et al. Lancet Haematol. 2022 Jul;9(7):e504-e513. doi: 10.1016/S2352-3026(22)00113-2. Epub 2022 May 19. Lancet Haematol. 2022. PMID: 35598604 Clinical Trial.
Camonsertib in DNA damage response-deficient advanced solid tumors: phase 1 trial results.
Yap TA, Fontana E, Lee EK, Spigel DR, Højgaard M, Lheureux S, Mettu NB, Carneiro BA, Carter L, Plummer R, Cote GM, Meric-Bernstam F, O'Connell J, Schonhoft JD, Wainszelbaum M, Fretland AJ, Manley P, Xu Y, Ulanet D, Rimkunas V, Zinda M, Koehler M, Silverman IM, Reis-Filho JS, Rosen E. Yap TA, et al. Nat Med. 2023 Jun;29(6):1400-1411. doi: 10.1038/s41591-023-02399-0. Epub 2023 Jun 5. Nat Med. 2023. PMID: 37277454 Free PMC article. Clinical Trial.
Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection.
Guo Y, Zhang G, Yang Q, Xie X, Lu Y, Cheng X, Wang H, Liang J, Tang J, Gao Y, Shang H, Dai J, Shi Y, Zhou J, Zhou J, Guo H, Yang H, Qi J, Liu L, Ma S, Zhang B, Huo Q, Xie Y, Wu J, Dong F, Zhang S, Lou Z, Gao Y, Song Z, Wang W, Sun Z, Yang X, Xiong D, Liu F, Chen X, Zhu P, Wang X, Cheng T, Rao Z. Guo Y, et al. Nat Commun. 2023 Jun 15;14(1):3537. doi: 10.1038/s41467-023-39267-x. Nat Commun. 2023. PMID: 37322000 Free PMC article.
We performed single-cell RNA sequencing (scRNA-seq) and BCR sequencing (scBCR-seq) of B cells from BA.1 breakthrough-infected patients who received 2 or 3 previous doses of inactivated vaccine. Elite nAbs, mainly derived from the IGHV2-5 and IGHV3-66/53 germlines, showed p …
We performed single-cell RNA sequencing (scRNA-seq) and BCR sequencing (scBCR-seq) of B cells from BA.1 breakthrough-infected patient …
Discovery and evaluation of active compounds from Xuanfei Baidu formula against COVID-19 via SARS-CoV-2 Mpro.
Zhang M, Liu L, Zhao Y, Cao Y, Zhu Y, Han L, Yang Q, Wang Y, Wang C, Zhang H, Wang Y, Zhang J. Zhang M, et al. Chin Med. 2023 Aug 2;18(1):94. doi: 10.1186/s13020-023-00790-0. Chin Med. 2023. PMID: 37528477 Free PMC article.
The surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) were undertaken to verify the binding affinity of ligand-M(pro). Omicron BA.1.1 and BA.2.3 variants were used to evaluate the antiviral activity of the focused compounds in non-cytotoxici …
The surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) were undertaken to verify the binding affinity of ligand-M(pr …
Betulinic acid attenuated bleomycin-induced pulmonary fibrosis by effectively intervening Wnt/β-catenin signaling.
Li X, Liu X, Deng R, Gao S, Jiang Q, Liu R, Li H, Miao Y, Zhai Y, Zhang S, Wang Z, Ren Y, Ning W, Zhou H, Yang C. Li X, et al. Phytomedicine. 2021 Jan;81:153428. doi: 10.1016/j.phymed.2020.153428. Epub 2020 Dec 1. Phytomedicine. 2021. PMID: 33341025
Study design Pulmonary fibrosis markers were detected in vitro and in vivo to confirm the antifibrotic effect of BA. The Wnt/beta-catenin pathway-related proteins were overexpressed to determine the effect of BA on Wnt signaling. METHODS AND RESULTS: BA dose- …
Study design Pulmonary fibrosis markers were detected in vitro and in vivo to confirm the antifibrotic effect of BA. The Wnt/beta-cat …
Ecological and health risk assessments and water quality criteria of heavy metals in the Haihe River.
Cui L, Wang X, Li J, Gao X, Zhang J, Liu Z. Cui L, et al. Environ Pollut. 2021 Dec 1;290:117971. doi: 10.1016/j.envpol.2021.117971. Epub 2021 Aug 14. Environ Pollut. 2021. PMID: 34438170
This study determined the concentrations of 14 heavy metals (As, Ba, Cd, Co, Cr, Cu, Hg, Mn, Ni, Pb, Sb, Se, Sn, and Zn) in water, sediments, and fish samples from the Haihe River basin. ...The results of a sensitivity analysis revealed that the highest contributing …
This study determined the concentrations of 14 heavy metals (As, Ba, Cd, Co, Cr, Cu, Hg, Mn, Ni, Pb, Sb, Se, Sn, and Zn) in water, se …
Biofilms retard the desorption of benzo(a)pyrene from polyethylene pellets in the marine environment.
Hao X, Zhang Y, Sun Y, Liu H, Zhang X, Li X, Ma Y, Niu Z. Hao X, et al. Mar Pollut Bull. 2023 Oct;195:115453. doi: 10.1016/j.marpolbul.2023.115453. Epub 2023 Sep 1. Mar Pollut Bull. 2023. PMID: 37660663
In this study, the pristine and benzo(a)pyrene (B[a]P) adsorbed polyethylene (PE) pellets were placed at Haihe Estuary (Tianjin, China) for 80 days to investigate desorption behavior. ...
In this study, the pristine and benzo(a)pyrene (B[a]P) adsorbed polyethylene (PE) pellets were placed at Haihe Estuary (Tianjin, Chin …
21 results