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Cancer vaccines based on whole-tumor lysate or neoepitopes with validated HLA binding outperform those with predicted HLA-binding affinity.
Fritah H, Graciotti M, Lai-Lai Chiang C, Huguenin-Bergenat AL, Petremand R, Ahmed R, Guillaume P, Schmidt J, Stevenson BJ, Gfeller D, Harari A, Kandalaft LE. Fritah H, et al. iScience. 2023 Feb 27;26(4):106288. doi: 10.1016/j.isci.2023.106288. eCollection 2023 Apr 21. iScience. 2023. PMID: 36950115 Free PMC article.