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Negative inotropic mechanisms of β-cardiotoxin in cardiomyocytes by depression of myofilament ATPase activity without activation of the classical β-adrenergic pathway.
Lertwanakarn T, Suntravat M, Sánchez EE, Wolska BM, Solaro RJ, de Tombe PP, Tachampa K. Lertwanakarn T, et al. Sci Rep. 2021 Oct 27;11(1):21154. doi: 10.1038/s41598-021-00282-x. Sci Rep. 2021. PMID: 34707114 Free PMC article.
Beta-cardiotoxin (beta-CTX) from the king cobra venom (Ophiophagus hannah) was previously proposed as a novel beta-adrenergic blocker. ...The effects of beta-CTX on isolated cardiac myocyte functions, calcium homeostasis, the phosphorylation level of targeted proteins, and …
Beta-cardiotoxin (beta-CTX) from the king cobra venom (Ophiophagus hannah) was previously proposed as a novel beta-adrenergic blocker …