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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 14
2003 27
2004 21
2005 19
2006 27
2007 35
2008 18
2009 27
2010 17
2011 24
2012 22
2013 31
2014 28
2015 21
2016 30
2017 32
2018 33
2019 25
2020 25
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416 results
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Oral Ixazomib, Lenalidomide, and Dexamethasone for Multiple Myeloma.
Moreau P, Masszi T, Grzasko N, Bahlis NJ, Hansson M, Pour L, Sandhu I, Ganly P, Baker BW, Jackson SR, Stoppa AM, Simpson DR, Gimsing P, Palumbo A, Garderet L, Cavo M, Kumar S, Touzeau C, Buadi FK, Laubach JP, Berg DT, Lin J, Di Bacco A, Hui AM, van de Velde H, Richardson PG; TOURMALINE-MM1 Study Group. Moreau P, et al. N Engl J Med. 2016 Apr 28;374(17):1621-34. doi: 10.1056/NEJMoa1516282. N Engl J Med. 2016. PMID: 27119237 Free article. Clinical Trial.
Carfilzomib and dexamethasone versus bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma (ENDEAVOR): a randomised, phase 3, open-label, multicentre study.
Dimopoulos MA, Moreau P, Palumbo A, Joshua D, Pour L, Hájek R, Facon T, Ludwig H, Oriol A, Goldschmidt H, Rosiñol L, Straub J, Suvorov A, Araujo C, Rimashevskaya E, Pika T, Gaidano G, Weisel K, Goranova-Marinova V, Schwarer A, Minuk L, Masszi T, Karamanesht I, Offidani M, Hungria V, Spencer A, Orlowski RZ, Gillenwater HH, Mohamed N, Feng S, Chng WJ; ENDEAVOR Investigators. Dimopoulos MA, et al. Lancet Oncol. 2016 Jan;17(1):27-38. doi: 10.1016/S1470-2045(15)00464-7. Epub 2015 Dec 5. Lancet Oncol. 2016. PMID: 26671818 Free article. Clinical Trial.
A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase.
Matyskiela ME, Lu G, Ito T, Pagarigan B, Lu CC, Miller K, Fang W, Wang NY, Nguyen D, Houston J, Carmel G, Tran T, Riley M, Nosaka L, Lander GC, Gaidarova S, Xu S, Ruchelman AL, Handa H, Carmichael J, Daniel TO, Cathers BE, Lopez-Girona A, Chamberlain PP. Matyskiela ME, et al. Among authors: Handa H. Nature. 2016 Jul 14;535(7611):252-7. doi: 10.1038/nature18611. Epub 2016 Jun 22. Nature. 2016. PMID: 27338790
Molecular mechanisms of cereblon-based drugs.
Asatsuma-Okumura T, Ito T, Handa H. Asatsuma-Okumura T, et al. Among authors: Handa H. Pharmacol Ther. 2019 Oct;202:132-139. doi: 10.1016/j.pharmthera.2019.06.004. Epub 2019 Jun 14. Pharmacol Ther. 2019. PMID: 31202702 Review.
The Role and Function of microRNA in the Pathogenesis of Multiple Myeloma.
Handa H, Murakami Y, Ishihara R, Kimura-Masuda K, Masuda Y. Handa H, et al. Cancers (Basel). 2019 Nov 6;11(11):1738. doi: 10.3390/cancers11111738. Cancers (Basel). 2019. PMID: 31698726 Free PMC article. Review.
Role of exosomes as a proinflammatory mediator in the development of EBV-associated lymphoma.
Higuchi H, Yamakawa N, Imadome KI, Yahata T, Kotaki R, Ogata J, Kakizaki M, Fujita K, Lu J, Yokoyama K, Okuyama K, Sato A, Takamatsu M, Kurosaki N, Alba SM, Azhim A, Horie R, Watanabe T, Kitamura T, Ando K, Kashiwagi T, Matsui T, Okamoto A, Handa H, Kuroda M, Nakamura N, Kotani A. Higuchi H, et al. Among authors: Handa H. Blood. 2018 Jun 7;131(23):2552-2567. doi: 10.1182/blood-2017-07-794529. Epub 2018 Apr 22. Blood. 2018. PMID: 29685921
Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon.
Nguyen TV, Lee JE, Sweredoski MJ, Yang SJ, Jeon SJ, Harrison JS, Yim JH, Lee SG, Handa H, Kuhlman B, Jeong JS, Reitsma JM, Park CS, Hess S, Deshaies RJ. Nguyen TV, et al. Among authors: Handa H. Mol Cell. 2016 Mar 17;61(6):809-20. doi: 10.1016/j.molcel.2016.02.032. Mol Cell. 2016. PMID: 26990986 Free PMC article.
Cystathionine β-synthase and PGRMC1 as CO sensors.
Kabe Y, Yamamoto T, Kajimura M, Sugiura Y, Koike I, Ohmura M, Nakamura T, Tokumoto Y, Tsugawa H, Handa H, Kobayashi T, Suematsu M. Kabe Y, et al. Among authors: Handa H. Free Radic Biol Med. 2016 Oct;99:333-344. doi: 10.1016/j.freeradbiomed.2016.08.025. Epub 2016 Aug 24. Free Radic Biol Med. 2016. PMID: 27565814 Review.
Cytomegalovirus retinitis followed by immune recovery uveitis in an elderly patient with rheumatoid arthritis undergoing administration of methotrexate and tofacitinib combination therapy.
Yanagisawa K, Ogawa Y, Hosogai M, Todokoro D, Mitsui T, Yokohama A, Kishi S, Handa H. Yanagisawa K, et al. Among authors: Handa H. J Infect Chemother. 2017 Aug;23(8):572-575. doi: 10.1016/j.jiac.2017.03.002. Epub 2017 Apr 25. J Infect Chemother. 2017. PMID: 28389165
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