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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1943 1
1947 2
1950 1
1951 1
1953 1
1954 3
1955 1
1956 3
1957 5
1958 8
1959 8
1960 4
1961 9
1962 13
1963 14
1964 18
1965 19
1966 23
1967 19
1968 32
1969 39
1970 40
1971 50
1972 60
1973 97
1974 79
1975 112
1976 165
1977 189
1978 185
1979 236
1980 229
1981 277
1982 288
1983 352
1984 361
1985 406
1986 447
1987 505
1988 527
1989 678
1990 686
1991 910
1992 1380
1993 1607
1994 1881
1995 1991
1996 2285
1997 2548
1998 2899
1999 3492
2000 4171
2001 5197
2002 5656
2003 6301
2004 6757
2005 6855
2006 6917
2007 7714
2008 9000
2009 9509
2010 10441
2011 11445
2012 12207
2013 12145
2014 12980
2015 13773
2016 13815
2017 13986
2018 14203
2019 14550
2020 16083
2021 16709
2022 9974
2023 1
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238,220 results
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The art of CHO cell engineering: A comprehensive retrospect and future perspectives.
Fischer S, Handrick R, Otte K. Fischer S, et al. Biotechnol Adv. 2015 Dec;33(8):1878-96. doi: 10.1016/j.biotechadv.2015.10.015. Epub 2015 Oct 31. Biotechnol Adv. 2015. PMID: 26523782 Review.
Chinese hamster ovary (CHO) cells represent the most frequently applied host cell system for industrial manufacturing of recombinant protein therapeutics. CHO cells are capable of producing high quality biologics exhibiting human-like post-translational modification …
Chinese hamster ovary (CHO) cells represent the most frequently applied host cell system for industrial manufacturing of recombinant …
Bioprocessing of Recombinant CHO-K1, CHO-DG44, and CHO-S: CHO Expression Hosts Favor Either mAb Production or Biomass Synthesis.
Reinhart D, Damjanovic L, Kaisermayer C, Sommeregger W, Gili A, Gasselhuber B, Castan A, Mayrhofer P, Grünwald-Gruber C, Kunert R. Reinhart D, et al. Biotechnol J. 2019 Mar;14(3):e1700686. doi: 10.1002/biot.201700686. Epub 2018 Jun 11. Biotechnol J. 2019. PMID: 29701329
Chinese hamster ovary (CHO) cells comprise a variety of lineages including CHO-DXB11, CHO-K1, CHO-DG44, and CHO-S. ...However, not much literature is available about the influence of genetic differences of CHO on the performance of biopro …
Chinese hamster ovary (CHO) cells comprise a variety of lineages including CHO-DXB11, CHO-K1, CHO-DG44, and C …
A high density CHO-S transient transfection system: Comparison of ExpiCHO and Expi293.
Jain NK, Barkowski-Clark S, Altman R, Johnson K, Sun F, Zmuda J, Liu CY, Kita A, Schulz R, Neill A, Ballinger R, Patel R, Liu J, Mpanda A, Huta B, Chiou H, Voegtli W, Panavas T. Jain NK, et al. Protein Expr Purif. 2017 Jun;134:38-46. doi: 10.1016/j.pep.2017.03.018. Epub 2017 Mar 23. Protein Expr Purif. 2017. PMID: 28342833
Chinese Hamster Ovary (CHO) cells are the principal mammalian host used for stable cell line generation and biotherapeutic protein production. ...Therefore, it is potentially advantageous to keep the host cell type consistent throughout drug discovery and development. To t …
Chinese Hamster Ovary (CHO) cells are the principal mammalian host used for stable cell line generation and biotherapeutic protein pr …
Cell engineering and cultivation of chinese hamster ovary (CHO) cells.
Omasa T, Onitsuka M, Kim WD. Omasa T, et al. Curr Pharm Biotechnol. 2010 Apr;11(3):233-40. doi: 10.2174/138920110791111960. Curr Pharm Biotechnol. 2010. PMID: 20210750 Review.
The CHO-based cultivation process is well established and is a general platform of therapeutic antibody production. ...This review provides an overview of the industrial production of therapeutic proteins using a CHO cell expression system....
The CHO-based cultivation process is well established and is a general platform of therapeutic antibody production. ...This review pr …
Carbohydrate intake during exercise and performance.
Jeukendrup AE. Jeukendrup AE. Nutrition. 2004 Jul-Aug;20(7-8):669-77. doi: 10.1016/j.nut.2004.04.017. Nutrition. 2004. PMID: 15212750 Review.
An analysis of all studies available shows that a single CHO ingested during exercise will be oxidized at rates up to about 1 g/min, even when large amounts of CHO are ingested. Combinations of CHO that use different intestinal transporters for absorption (e. …
An analysis of all studies available shows that a single CHO ingested during exercise will be oxidized at rates up to about 1 g/min, …
Coingestion of Carbohydrate and Protein on Muscle Glycogen Synthesis after Exercise: A Meta-analysis.
Margolis LM, Allen JT, Hatch-McChesney A, Pasiakos SM. Margolis LM, et al. Med Sci Sports Exerc. 2021 Feb 1;53(2):384-393. doi: 10.1249/MSS.0000000000002476. Med Sci Sports Exerc. 2021. PMID: 32826640 Free PMC article.
The purpose of this study was determine the overall effects of CHO-PRO and the independent effects of energy and relative carbohydrate content of CHO-PRO supplementation on postexercise muscle glycogen synthesis compared with CHO alone. METHODS: Meta-analysis …
The purpose of this study was determine the overall effects of CHO-PRO and the independent effects of energy and relative carbohydrat …
Fat adaptation in well-trained athletes: effects on cell metabolism.
Yeo WK, Carey AL, Burke L, Spriet LL, Hawley JA. Yeo WK, et al. Appl Physiol Nutr Metab. 2011 Feb;36(1):12-22. doi: 10.1139/H10-089. Appl Physiol Nutr Metab. 2011. PMID: 21326374 Review.
One such strategy is "fat adaptation", an intervention in which well-trained endurance athletes consume a high-fat, low-CHO diet for up to 2 weeks while undertaking their normal training and then immediately follow this by CHO restoration (consuming a high-CHO …
One such strategy is "fat adaptation", an intervention in which well-trained endurance athletes consume a high-fat, low-CHO diet for …
Hyperosmolality in CHO culture: Effects on cellular behavior and morphology.
Romanova N, Niemann T, Greiner JFW, Kaltschmidt B, Kaltschmidt C, Noll T. Romanova N, et al. Biotechnol Bioeng. 2021 Jun;118(6):2348-2359. doi: 10.1002/bit.27747. Epub 2021 Mar 27. Biotechnol Bioeng. 2021. PMID: 33751545
Extending previous observation on osmotic adaptation, the present study investigates for the first time potential effects of hyperosmolality on CHO cells on both population and single-cell level. We intentionally exposed CHO cells to hyperosmolality of up to 545 mOs …
Extending previous observation on osmotic adaptation, the present study investigates for the first time potential effects of hyperosmolality …
International Society of Sports Nutrition position stand: nutrient timing.
Kerksick C, Harvey T, Stout J, Campbell B, Wilborn C, Kreider R, Kalman D, Ziegenfuss T, Lopez H, Landis J, Ivy JL, Antonio J. Kerksick C, et al. J Int Soc Sports Nutr. 2008 Oct 3;5:17. doi: 10.1186/1550-2783-5-17. J Int Soc Sports Nutr. 2008. PMID: 18834505 Free PMC article.
During exercise, CHO should be consumed at a rate of 30 - 60 grams of CHO/hour in a 6 - 8% CHO solution (8 - 16 fluid ounces) every 10 - 15 minutes. ...Post-exercise (within 30 minutes) consumption of CHO at high dosages (8 - 10 g CHO/kg/day) ha …
During exercise, CHO should be consumed at a rate of 30 - 60 grams of CHO/hour in a 6 - 8% CHO solution (8 - 16 fluid o …
An 'omics approach towards CHO cell engineering.
Datta P, Linhardt RJ, Sharfstein ST. Datta P, et al. Biotechnol Bioeng. 2013 May;110(5):1255-71. doi: 10.1002/bit.24841. Epub 2013 Feb 4. Biotechnol Bioeng. 2013. PMID: 23322664 Review.
In parallel, recent advances in techniques and tools for decoding the CHO cell genome, transcriptome, proteome, and glycome have led to new areas of study for better understanding the metabolic pathways in CHO cells with the long-term goal of developing new biologic …
In parallel, recent advances in techniques and tools for decoding the CHO cell genome, transcriptome, proteome, and glycome have led …
238,220 results
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