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Showing results for hyoja ha
Search for Hyoji Ha instead (1 results)
Target-specific gene silencing of layer-by-layer assembled gold-cysteamine/siRNA/PEI/HA nanocomplex.
Lee MY, Park SJ, Park K, Kim KS, Lee H, Hahn SK. Lee MY, et al. ACS Nano. 2011 Aug 23;5(8):6138-47. doi: 10.1021/nn2017793. Epub 2011 Jul 8. ACS Nano. 2011. PMID: 21739990
In this work, a cysteamine modified gold nanoparticles (AuCM)/siRNA/polyethyleneimine (PEI)/hyaluronic acid (HA) complex was successfully developed using a layer-by-layer method for target-specific intracellular delivery of siRNA by HA receptor mediated endocytosis. …
In this work, a cysteamine modified gold nanoparticles (AuCM)/siRNA/polyethyleneimine (PEI)/hyaluronic acid (HA) complex was successf …
Target specific and long-acting delivery of protein, peptide, and nucleotide therapeutics using hyaluronic acid derivatives.
Oh EJ, Park K, Kim KS, Kim J, Yang JA, Kong JH, Lee MY, Hoffman AS, Hahn SK. Oh EJ, et al. J Control Release. 2010 Jan 4;141(1):2-12. doi: 10.1016/j.jconrel.2009.09.010. Epub 2009 Sep 13. J Control Release. 2010. PMID: 19758573 Review.
According to the real-time bio-imaging of HA derivatives using quantum dots (QDot), HA-QDot conjugates with 35mol% HA modification maintaining enough binding sites for HA receptors were mainly accumulated in the liver, while those with 68mol% HA
According to the real-time bio-imaging of HA derivatives using quantum dots (QDot), HA-QDot conjugates with 35mol% HA m …
Target specific systemic delivery of TGF-beta siRNA/(PEI-SS)-g-HA complex for the treatment of liver cirrhosis.
Park K, Hong SW, Hur W, Lee MY, Yang JA, Kim SW, Yoon SK, Hahn SK. Park K, et al. Biomaterials. 2011 Jul;32(21):4951-8. doi: 10.1016/j.biomaterials.2011.03.044. Epub 2011 Apr 11. Biomaterials. 2011. PMID: 21481451
The confocal microscopic and fluorometric analyses confirmed the effective cellular uptake of siRNA/(PEI-SS)-g-HA complex by HA receptor mediated endocytosis. In vitro gene silencing efficiency was ca. 80% in the presence of 10 vol% serum and ca. 50% in the presence …
The confocal microscopic and fluorometric analyses confirmed the effective cellular uptake of siRNA/(PEI-SS)-g-HA complex by HA
Effect of osteoconductive hyaluronate hydrogels on calvarial bone regeneration.
Yeom J, Hwang BW, Yang DJ, Shin HI, Hahn SK. Yeom J, et al. Biomater Res. 2014 Jul 23;18:8. doi: 10.1186/2055-7124-18-8. eCollection 2014. Biomater Res. 2014. PMID: 26331059 Free PMC article.
RESULTS: HA hydrogels were synthesized by the crosslinking reaction between carboxyl groups of HA and amine groups of gelatin (GEL). Then, artificial bone grafts were prepared by mixing MGSB with HA-GEL hydrogels. In vitro proliferation of preosteogenic cells …
RESULTS: HA hydrogels were synthesized by the crosslinking reaction between carboxyl groups of HA and amine groups of gelatin …
Transdermal delivery of hyaluronic acid -- human growth hormone conjugate.
Yang JA, Kim ES, Kwon JH, Kim H, Shin JH, Yun SH, Choi KY, Hahn SK. Yang JA, et al. Biomaterials. 2012 Sep;33(25):5947-54. doi: 10.1016/j.biomaterials.2012.05.003. Epub 2012 May 25. Biomaterials. 2012. PMID: 22632765
Hyaluronic acid (HA) is one of the major components of extracellular matrix (ECM). ...HA-hGH conjugate was synthesized by specific coupling reaction between aldehyde modified HA and the N-terminal amine group of hGH. ...
Hyaluronic acid (HA) is one of the major components of extracellular matrix (ECM). ...HA-hGH conjugate was synthesized by spec …
Targeted systemic mesenchymal stem cell delivery using hyaluronate - wheat germ agglutinin conjugate.
Kim YS, Kong WH, Kim H, Hahn SK. Kim YS, et al. Biomaterials. 2016 Nov;106:217-27. doi: 10.1016/j.biomaterials.2016.08.027. Epub 2016 Aug 18. Biomaterials. 2016. PMID: 27569867
A variety of receptors for hyaluronate (HA), a natural linear polysaccharide, were found in the body, which have been exploited as target sites for HA-based drug delivery systems. ...WGA was conjugated to HA by coupling reaction between aldehyde-modified H
A variety of receptors for hyaluronate (HA), a natural linear polysaccharide, were found in the body, which have been exploited as ta …
Reducible hyaluronic acid-siRNA conjugate for target specific gene silencing.
Park K, Yang JA, Lee MY, Lee H, Hahn SK. Park K, et al. Bioconjug Chem. 2013 Jul 17;24(7):1201-9. doi: 10.1021/bc4001257. Epub 2013 Jun 17. Bioconjug Chem. 2013. PMID: 23731084
The HA-siRNA/LPEI complex had a mean particle size of ca. 250 nm and a negative or neutral surface charge at physiological condition. The reducible HA-siRNA/LPEI complex showed a higher in vitro gene silencing efficiency than noncleavable HA-siRNA/LPEI comple …
The HA-siRNA/LPEI complex had a mean particle size of ca. 250 nm and a negative or neutral surface charge at physiological condition. …
Hyaluronic acid-polyethyleneimine conjugate for target specific intracellular delivery of siRNA.
Jiang G, Park K, Kim J, Kim KS, Oh EJ, Kang H, Han SE, Oh YK, Park TG, Kwang Hahn S. Jiang G, et al. Biopolymers. 2008 Jul;89(7):635-42. doi: 10.1002/bip.20978. Biopolymers. 2008. PMID: 18322932
In addition, the inhibited PGL3-Luc gene silencing effect in the presence of free HA in the transfection medium revealed that siRNA/HA-PEI complex was selectively taken up to B16F1 cells via HA receptor mediated endocytosis. All these results demonstrated tha …
In addition, the inhibited PGL3-Luc gene silencing effect in the presence of free HA in the transfection medium revealed that siRNA/ …
Injectable hyaluronic acid microhydrogels for controlled release formulation of erythropoietin.
Hahn SK, Kim JS, Shimobouji T. Hahn SK, et al. J Biomed Mater Res A. 2007 Mar 15;80(4):916-24. doi: 10.1002/jbm.a.30997. J Biomed Mater Res A. 2007. PMID: 17072846
HA hydrogels were prepared by the disulfide bond formation of thiolated HA (HA-SH). ...HA-SH microhydrogels were prepared by the reactive spray drying of diluted HA-SH precursor solution. ...
HA hydrogels were prepared by the disulfide bond formation of thiolated HA (HA-SH). ...HA-SH microhydrogels were
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