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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1988 2
1990 2
1991 1
1992 1
1993 2
1996 3
1997 2
1998 3
1999 3
2000 4
2001 1
2002 4
2003 4
2004 2
2005 12
2006 6
2007 12
2008 9
2009 8
2010 13
2011 11
2012 9
2013 8
2014 9
2015 14
2016 12
2017 9
2018 4
2019 4
2020 4
2021 4
2022 2
2023 7
2024 13
2025 8

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201 results

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Page 1
Stepwise activation of a metabotropic glutamate receptor.
Krishna Kumar K, Wang H, Habrian C, Latorraca NR, Xu J, O'Brien ES, Zhang C, Montabana E, Koehl A, Marqusee S, Isacoff EY, Kobilka BK. Krishna Kumar K, et al. Among authors: isacoff ey. Nature. 2024 May;629(8013):951-956. doi: 10.1038/s41586-024-07327-x. Epub 2024 Apr 17. Nature. 2024. PMID: 38632403 Free PMC article.
Negative allosteric modulation of the glucagon receptor by RAMP2.
Krishna Kumar K, O'Brien ES, Habrian CH, Latorraca NR, Wang H, Tuneew I, Montabana E, Marqusee S, Hilger D, Isacoff EY, Mathiesen JM, Kobilka BK. Krishna Kumar K, et al. Among authors: isacoff ey. Cell. 2023 Mar 30;186(7):1465-1477.e18. doi: 10.1016/j.cell.2023.02.028. Cell. 2023. PMID: 37001505 Free PMC article.
Photopharmacology for vision restoration.
Berry MH, Holt A, Broichhagen J, Donthamsetti P, Flannery JG, Isacoff EY. Berry MH, et al. Among authors: isacoff ey. Curr Opin Pharmacol. 2022 Aug;65:102259. doi: 10.1016/j.coph.2022.102259. Epub 2022 Jun 21. Curr Opin Pharmacol. 2022. PMID: 35749908 Free article. Review.
Development of covalent chemogenetic K2P channel activators.
Deal PE, Lee H, Mondal A, Lolicato M, Mendonça PRF, Black H, Jang S, El-Hilali X, Bryant C, Isacoff EY, Renslo AR, Minor DL Jr. Deal PE, et al. Among authors: isacoff ey. Cell Chem Biol. 2024 Jul 18;31(7):1305-1323.e9. doi: 10.1016/j.chembiol.2024.06.006. Cell Chem Biol. 2024. PMID: 39029456
Subtype-specific conformational landscape of NMDA receptor gating.
Bleier J, Furtado de Mendonca PR, Habrian CH, Stanley C, Vyklicky V, Isacoff EY. Bleier J, et al. Among authors: isacoff ey. Cell Rep. 2024 Aug 27;43(8):114634. doi: 10.1016/j.celrep.2024.114634. Epub 2024 Aug 17. Cell Rep. 2024. PMID: 39154344 Free PMC article.
Structure and dynamics determine G protein coupling specificity at a class A GPCR.
Casiraghi M, Wang H, Brennan PC, Habrian C, Hübner H, Schmidt MF, Maul L, Pani B, Bahriz SMFM, Xu B, Staffen N, Assafa TE, Chen B, White E, Sunahara RK, Inoue A, Xiang YK, Lefkowitz RJ, Isacoff EY, Nucci N, Gmeiner P, Lerch MT, Kobilka BK. Casiraghi M, et al. Among authors: isacoff ey. Sci Adv. 2025 Mar 21;11(12):eadq3971. doi: 10.1126/sciadv.adq3971. Epub 2025 Mar 19. Sci Adv. 2025. PMID: 40106559 Free PMC article.
Structure and dynamics determine G protein coupling specificity at a class A GPCR.
Casiraghi M, Wang H, Brennan P, Habrian C, Hubner H, Schmidt MF, Maul L, Pani B, Bahriz SM, Xu B, White E, Sunahara RK, Xiang YK, Lefkowitz RJ, Isacoff EY, Nucci N, Gmeiner P, Lerch M, Kobilka BK. Casiraghi M, et al. Among authors: isacoff ey. bioRxiv [Preprint]. 2025 Jan 31:2024.03.28.587240. doi: 10.1101/2024.03.28.587240. bioRxiv. 2025. Update in: Sci Adv. 2025 Mar 21;11(12):eadq3971. doi: 10.1126/sciadv.adq3971. PMID: 38586060 Free PMC article. Updated. Preprint.
Coupling sensor to enzyme in the voltage sensing phosphatase.
Yu Y, Zhang L, Li B, Fu Z, Brohawn SG, Isacoff EY. Yu Y, et al. Among authors: isacoff ey. Nat Commun. 2024 Jul 30;15(1):6409. doi: 10.1038/s41467-024-50319-8. Nat Commun. 2024. PMID: 39080263 Free PMC article.
New technologies.
Isacoff E, Smith SJ. Isacoff E, et al. Curr Opin Neurobiol. 2009 Oct;19(5):511-2. doi: 10.1016/j.conb.2009.10.012. Epub 2009 Nov 5. Curr Opin Neurobiol. 2009. PMID: 19896828 Free article. No abstract available.
Restoring Vision to the Blind with Chemical Photoswitches.
Tochitsky I, Kienzler MA, Isacoff E, Kramer RH. Tochitsky I, et al. Among authors: isacoff e. Chem Rev. 2018 Nov 14;118(21):10748-10773. doi: 10.1021/acs.chemrev.7b00723. Epub 2018 Jun 6. Chem Rev. 2018. PMID: 29874052 Free PMC article. Review.
201 results